Ki Summary

Reaction Details

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Target

Activin receptor type-1 [172-499,R206H]

Ligand

BDBM451806

Substrate/Competitor

n/a

Meas. Tech.

Caliper Assay

IC50

7.00±n/a nM

Citation

Arista, L; Babu, S; Bian, J; Cui, K; Dillon, MP; Lattmann, R; Li, J; Liao, L; Lizos, D; Ramos, R; Stiefl, NJ; Ullrich, T; Usselmann, P; Wang, X; Waykole, LM; Weiler, S; Zhang, Y; Zhou, Y; Zhu, T Aminopyridine derivatives and their use as selective ALK-2 inhibitors US Patent US10710980 Publication Date 7/14/2020

More Info.:

Get all data from this article, Assay Method

Activin receptor type-1 [172-499,R206H]

Name:

Activin receptor type-1 [172-499,R206H]

Synonyms:

ACVR1 | ACVR1_HUMAN | ACVRLK2 | Activin receptor type-1 (ALK2 FOP) (R206H aa 172-499) | Activin receptor type-1 (ALK2)(FOP)(R206H)

Type:

Enzyme Catalytic Domain

Mol. Mass.:

37120.09

Organism:

Homo sapiens (Human)

Description:

aa 172-499

Residue:

328

Sequence:

TTNVGDSTLADLLDHSCTSGSGSGLPFLVQRTVAHQITLLECVGKGRYGEVWRGSWQGEN
VAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSL
YDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCC
IADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVL
WEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLA
KLMKECWYQNPSARLTALRIKKTLTKID

BDBM451806

n/a

Name

BDBM451806

Synonyms:

US10710980, Example 38 | US10947218, Example 38

Type

Small organic molecule

Emp. Form.

C27H34N4O3

Mol. Mass.

462.5839

SMILES

Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(cc1)[C@]12C[C@H]1CN(CC1COC1)C2 |r,wU:25.27,10.10,wD:23.25,13.14,(-4.7,4.87,;-3.37,4.1,;-2.03,4.87,;-.7,4.1,;-.7,2.56,;-2.03,1.79,;-3.37,2.56,;-4.7,1.79,;-6.03,2.56,;-4.7,.25,;-6.19,-.15,;-6.58,-1.64,;-8.07,-2.04,;-9.16,-.95,;-10.65,-1.35,;-8.76,.54,;-7.28,.94,;.64,1.79,;.64,.25,;1.97,-.52,;3.3,.25,;3.3,1.79,;1.97,2.56,;4.64,-.52,;4.8,1.01,;6.04,.11,;7.07,-1.04,;6.3,-2.37,;6.93,-3.78,;8.47,-3.78,;9.56,-4.87,;10.65,-3.78,;9.56,-2.69,;4.8,-2.05,)|

Structure