Reaction Details |
| Report a problem with these data |
Target | Coagulation factor XI |
---|
Ligand | BDBM335416 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | Enzyme Activity Assay |
---|
IC50 | 1.10±n/a nM |
---|
Citation | Courtney, S; Yarnold, C; Flanagan, S; Brace, G; Barker, J; Ichihara, O; Gadouleau, E; Richardson, A; Kondo, T; Imagawa, A; Nakatani, S; Suzuki, R; Kouyama, S Pyrimidinone and its derivatives inhibiting factor XIa US Patent US10717738 Publication Date 7/21/2020 |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Coagulation factor XI |
---|
Name: | Coagulation factor XI |
Synonyms: | Coagulation factor XIa | Coagulation factor XIa heavy chain | Coagulation factor XIa light chain | F11 | FA11_HUMAN | FXI | Factor XIa | Factor XIa (fXIa) | PTA | Plasma thromboplastin antecedent |
Type: | Enzyme |
Mol. Mass.: | 70130.58 |
Organism: | Homo sapiens (Human) |
Description: | P03951 |
Residue: | 625 |
Sequence: | MIFLYQVVHFILFTSVSGECVTQLLKDTCFEGGDITTVFTPSAKYCQVVCTYHPRCLLFT
FTAESPSEDPTRWFTCVLKDSVTETLPRVNRTAAISGYSFKQCSHQISACNKDIYVDLDM
KGINYNSSVAKSAQECQERCTDDVHCHFFTYATRQFPSLEHRNICLLKHTQTGTPTRITK
LDKVVSGFSLKSCALSNLACIRDIFPNTVFADSNIDSVMAPDAFVCGRICTHHPGCLFFT
FFSQEWPKESQRNLCLLKTSESGLPSTRIKKSKALSGFSLQSCRHSIPVFCHSSFYHDTD
FLGEELDIVAAKSHEACQKLCTNAVRCQFFTYTPAQASCNEGKGKCYLKLSSNGSPTKIL
HGRGGISGYTLRLCKMDNECTTKIKPRIVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSI
IGNQWILTAAHCFYGVESPKILRVYSGILNQSEIKEDTSFFGVQEIIIHDQYKMAESGYD
IALLKLETTVNYTDSQRPICLPSKGDRNVIYTDCWVTGWGYRKLRDKIQNTLQKAKIPLV
TNEECQKRYRGHKITHKMICAGYREGGKDACKGDSGGPLSCKHNEVWHLVGITSWGEGCA
QRERPGVYTNVVEYVDWILEKTQAV
|
|
|
BDBM335416 |
---|
n/a |
---|
Name | BDBM335416 |
Synonyms: | 5-(2-{(3S)-7-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]-5-oxo-1,2,3,5-tetrahydro-3-indolizinyl}-4-fluoro-1H-imidazol-5-yl)-2-thiophenecarboxylic acid trifluoroacetate | US10717738, Example 399 | US9732085, 399 |
Type | Small organic molecule |
Emp. Form. | C23H15ClFN7O3S |
Mol. Mass. | 523.927 |
SMILES | OC(=O)c1ccc(s1)-c1[nH]c(nc1F)[C@@H]1CCc2cc(cc(=O)n12)-c1cc(Cl)ccc1-n1cnnn1 |r| |
Structure |
|