Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Serine/threonine-protein kinase B-raf | ||
| Ligand | BDBM221685 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Amplified Luminescence Proximity Homogeneous Assay | ||
| IC50 | 3.90±n/a nM | ||
| Citation |  Huang, S; Jin, X; Liu, Z; Poon, D; Tellew, J; Wan, Y; Wang, X; Xie, Y Compounds and compositions as protein kinase inhibitors US Patent US9593099 Publication Date 3/14/2017 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Serine/threonine-protein kinase B-raf | |||
| Name: | Serine/threonine-protein kinase B-raf | ||
| Synonyms: | B-RAF | B-Raf Protein Kinase | B-Raf proto-oncogene serine/threonine-protein kinase | BRAF | BRAF1 | BRAF_HUMAN | RAFB1 | p94 | v-Raf murine sarcoma viral oncogene homolog B1 | ||
| Type: | Serine/threonine-protein kinase | ||
| Mol. Mass.: | 84446.00 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P15056 | ||
| Residue: | 766 | ||
| Sequence: |
| ||
| BDBM221685 | |||
| n/a | |||
| Name | BDBM221685 | ||
| Synonyms: | US10568884, Cpd 6 | US9314464, 6 | US9593100, Compound 6 | USRE49556, Compound 6 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C22H27F2N7O4S | ||
| Mol. Mass. | 523.556 | ||
| SMILES | COC(=O)N[C@@H](C)CNc1nccc(n1)-c1cn(nc1-c1c(F)ccc(NS(C)(=O)=O)c1F)C(C)C |r,wD:5.5,(-7.74,6.48,;-6.41,5.71,;-5.08,6.48,;-5.08,8.02,;-3.74,5.71,;-3.74,4.17,;-5.08,3.4,;-2.41,3.4,;-2.41,1.86,;-1.08,1.09,;.26,1.86,;1.59,1.09,;1.59,-.45,;.26,-1.22,;-1.08,-.45,;.26,-2.76,;-.99,-3.66,;-.51,-5.13,;1.03,-5.13,;1.5,-3.66,;2.99,-3.27,;3.39,-1.78,;2.3,-.69,;4.88,-1.38,;5.97,-2.47,;5.57,-3.96,;6.66,-5.05,;6.26,-6.53,;5.86,-8.02,;4.77,-6.13,;7.74,-6.93,;4.08,-4.36,;3.68,-5.84,;-1.28,-6.46,;-.51,-7.8,;-2.82,-6.46,)| | ||
| Structure | 
| ||