Reaction Details | |||
---|---|---|---|
Report a problem with these data | |||
Target | Bile acid receptor | ||
Ligand | BDBM465425 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Binding Assay | ||
EC50 | 25.1±n/a nM | ||
Citation | Chao, J; Jain, R; Hu, L; Lewis, JG; Baribault, H; Caldwell, J Hormone receptor modulators for treating metabolic conditions and disorders US Patent US10793568 Publication Date 10/6/2020 | ||
More Info.: | Get all data from this article, Assay Method | ||
Bile acid receptor | |||
Name: | Bile acid receptor | ||
Synonyms: | BAR | Bile acid receptor FXR | FXR | Farnesol receptor HRR-1 | HRR1 | NR1H4 | NR1H4_HUMAN | Nuclear receptor subfamily 1 group H member 4 | RIP14 | RXR-interacting protein 14 | Retinoid X receptor-interacting protein 14 | farnesoid x receptor | ||
Type: | Nuclear Receptor | ||
Mol. Mass.: | 55916.24 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q96RI1 | ||
Residue: | 486 | ||
Sequence: |
| ||
BDBM465425 | |||
n/a | |||
Name | BDBM465425 | ||
Synonyms: | US10793568, Compound I-44 | ||
Type | Small organic molecule | ||
Emp. Form. | C26H20Cl2F2N2O5 | ||
Mol. Mass. | 549.35 | ||
SMILES | OC(=O)c1ccc(N2C[C@@H]3C[C@H]2C[C@H]3OC(=O)c2c(noc2C2(F)CC2)-c2c(Cl)cccc2Cl)c(F)c1 |wU:13.15,9.9,wD:11.10,THB:6:7:13.12:10,14:13:8.7:10,(4.05,-10.8,;5.06,-9.64,;6.57,-9.93,;4.56,-8.18,;3.05,-7.88,;2.55,-6.43,;3.56,-5.27,;3.06,-3.81,;3.61,-2.64,;2.13,-1.77,;1.83,-.25,;1.7,-3.12,;.25,-3.85,;.93,-2.61,;-.21,-1.58,;-1.68,-2.06,;-1.99,-3.57,;-2.82,-1.03,;-4.33,-1.36,;-5.1,-.02,;-4.07,1.12,;-2.66,.5,;-1.33,1.27,;-.34,.09,;-.34,2.45,;-1.86,2.72,;-4.95,-2.76,;-6.48,-2.93,;-7.39,-1.68,;-7.11,-4.33,;-6.2,-5.58,;-4.67,-5.42,;-4.04,-4.01,;-2.51,-3.84,;5.07,-5.56,;6.09,-4.4,;5.57,-7.02,)| | ||
Structure |