| Reaction Details |
|---|
 | Report a problem with these data |
| Target | WD repeat-containing protein 5 |
|---|
| Ligand | BDBM468736 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | TR-FRET Binding Assay |
|---|
| Ki | 0.020±n/a nM |
|---|
| Citation |  Gogliotti, RD; Stauffer, SR; Jeon, K; Salovich, JM; Macdonald, JD; Mills, JJ; Meyers, KM; Alvarado, JR; Han, C; Fesik, SW; Lee, T WDR5-MLL1 inhibitors and modulators US Patent US10807959 Publication Date 10/20/2020 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| WD repeat-containing protein 5 |
|---|
| Name: | WD repeat-containing protein 5 |
|---|
| Synonyms: | BIG3 | WD repeat-containing protein 5 | WD repeat-containing protein 5 (WDR5) | WD repeat-containing protein 5 (WRD5) | WDR5 | WDR5_HUMAN |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 36597.13 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P61964 |
|---|
| Residue: | 334 |
|---|
| Sequence: | MATEEKKPETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWL
ASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGK
CLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFN
RDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKL
WDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGH
TDVVISTACHPTENIIASAALENDKTIKLWKSDC
|
|
|
|---|
| BDBM468736 |
|---|
| n/a |
|---|
| Name | BDBM468736 |
|---|
| Synonyms: | US10807959, Example 5 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C25H25ClFN5O |
|---|
| Mol. Mass. | 465.95 |
|---|
| SMILES | Cc1cc(CNC(=O)c2cc(CNC3=NCCN3)cc(c2)-c2ccc(F)nc2C)ccc1Cl |t:13| |
|---|
| Structure | 
|
|---|
Search and Browse
