Reaction Details | |||
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Target | Mu-type opioid receptor | ||
Ligand | BDBM469461 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Human Mu-Opioid Peptide (hMOP) Receptor Binding Assay | ||
Ki | 1.000±n/a nM | ||
Citation | Kuehnert, S; Koenigs, R; Kless, A; Wegert, A; Konetzki, I; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W 3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent US10807988 Publication Date 10/20/2020 | ||
More Info.: | Get all data from this article, Assay Method | ||
Mu-type opioid receptor | |||
Name: | Mu-type opioid receptor | ||
Synonyms: | M-OR-1 | MOP | MOR-1 | MOR1 | MUOR1 | Mu Opioid Receptor | Mu opiate receptor | OPIATE Mu | OPRM1 | OPRM_HUMAN | hMOP | mu-type opioid receptor isoform MOR-1 | ||
Type: | G Protein-Coupled Receptor (GPCR) | ||
Mol. Mass.: | 44789.51 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P35372 | ||
Residue: | 400 | ||
Sequence: |
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BDBM469461 | |||
n/a | |||
Name | BDBM469461 | ||
Synonyms: | US10807988, Example SC_3103 | cis-1-(Cyclobutyl-methyl)-8-dimethylamino-3-[4-methyl-6-(trifluoromethyl)- pyridin-3-yl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one | ||
Type | Small organic molecule | ||
Emp. Form. | C28H35F3N4O | ||
Mol. Mass. | 500.5989 | ||
SMILES | CN(C)[C@]1(CC[C@]2(CN(C(=O)N2CC2CCC2)c2cnc(cc2C)C(F)(F)F)CC1)c1ccccc1 |r,wU:6.11,3.2,(4.04,-5.47,;4.81,-6.8,;6.35,-6.8,;4.04,-8.13,;3.27,-9.47,;1.73,-9.47,;.96,-8.13,;.06,-6.89,;-1.41,-7.36,;-1.41,-8.9,;-2.65,-9.81,;.06,-9.38,;.53,-10.84,;-.5,-11.99,;-2.04,-11.99,;-2.04,-13.53,;-.5,-13.53,;-2.74,-6.59,;-4.07,-7.36,;-5.41,-6.59,;-5.41,-5.05,;-4.07,-4.28,;-2.74,-5.05,;-1.41,-4.28,;-6.74,-4.28,;-8.07,-3.51,;-5.97,-2.95,;-7.51,-5.62,;1.73,-6.8,;3.27,-6.8,;4.81,-9.47,;4.04,-10.8,;4.81,-12.14,;6.35,-12.14,;7.12,-10.8,;6.35,-9.47,)| | ||
Structure |