Found 2211 hits with Last Name = 'linz' and Initial = 'k' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Nociceptin receptor
(Homo sapiens (Human)) | BDBM50100983
(CHEMBL3326224)Show SMILES Cl.CN(C)[C@]1(CC[C@@]2(CC1)OCCc1c2[nH]c2ccccc12)c1ccccc1 |r,wU:4.2,wD:7.9,(22.71,-7.97,;18.3,-7.93,;16.96,-7.16,;16.96,-5.62,;15.63,-7.93,;14.86,-9.26,;13.32,-9.27,;12.55,-7.94,;13.32,-6.61,;14.86,-6.6,;11.79,-9.28,;10.25,-9.27,;9.47,-7.94,;10.25,-6.6,;11.79,-6.61,;12.26,-5.14,;11.03,-4.24,;10.87,-2.7,;9.47,-2.07,;8.21,-2.98,;8.37,-4.51,;9.77,-5.14,;16.43,-9.25,;15.68,-10.6,;16.48,-11.91,;18.02,-11.88,;18.76,-10.52,;17.96,-9.21,)| | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmacokinetics
Curated by ChEMBL
| Assay Description
Displacement of [3H]nociceptin from human NOP receptor expressed in CHO-K1 cells by scintillation proximity assay |
ACS Med Chem Lett 5: 857-62 (2014)
Article DOI: 10.1021/ml500117c
BindingDB Entry DOI: 10.7270/Q25140ZK |
More data for this
Ligand-Target Pair | |
Nociceptin receptor
(Homo sapiens (Human)) | BDBM239934
(US9403767, 117)Show SMILES CN(C)C1(CCC(CC1)(N(C)C(=O)c1cccc(F)c1)c1ccccc1)c1ccccc1 |(-6.07,4.12,;-5.44,2.71,;-3.93,3.03,;-5.44,1.17,;-6.26,-.13,;-5.53,-1.49,;-3.99,-1.55,;-3.18,-.24,;-3.9,1.12,;-3.99,-3.09,;-3.37,-4.49,;-5.33,-3.86,;-6.66,-3.09,;-5.33,-5.4,;-6.66,-6.17,;-6.66,-7.71,;-5.33,-8.48,;-3.99,-7.71,;-2.66,-8.48,;-3.99,-6.17,;-2.72,-2.41,;-1.33,-1.73,;-.06,-2.6,;-.16,-4.13,;-1.55,-4.81,;-2.82,-3.95,;-6.72,2.03,;-8.1,1.36,;-9.38,2.22,;-9.27,3.76,;-7.88,4.43,;-6.61,3.57,)| Show InChI InChI=1S/C28H31FN2O/c1-30(2)27(23-12-6-4-7-13-23)17-19-28(20-18-27,24-14-8-5-9-15-24)31(3)26(32)22-11-10-16-25(29)21-22/h4-16,21H,17-20H2,1-3H3 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| 0.130 | n/a | n/a | n/a | n/a | n/a | n/a | 7.4 | n/a |
GRUENENTHAL GMBH
US Patent
| Assay Description
The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste... |
US Patent US9403767 (2016)
BindingDB Entry DOI: 10.7270/Q23R0RSJ |
More data for this
Ligand-Target Pair | |
Nociceptin receptor
(Homo sapiens (Human)) | BDBM50101099
(CHEMBL3326228)Show SMILES Cl.CN(C)[C@]1(CC[C@@]2(CC1)NCCc1c2[nH]c2ccccc12)c1ccccc1 |r,wU:4.2,wD:7.9,(19.24,-9.37,;10.32,-12.36,;8.84,-12.77,;7.74,-11.68,;8.44,-14.27,;7.67,-15.59,;6.14,-15.59,;5.38,-14.26,;6.14,-12.93,;7.68,-12.94,;4.47,-15.52,;2.93,-15.35,;2.3,-13.94,;3.21,-12.69,;4.75,-12.85,;5.38,-11.44,;4.23,-10.41,;4.23,-8.85,;2.89,-8.09,;1.56,-8.86,;1.56,-10.41,;2.89,-11.18,;9.98,-14.28,;10.74,-15.62,;12.28,-15.63,;13.06,-14.29,;12.29,-12.95,;10.75,-12.95,)| | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.190 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmacokinetics
Curated by ChEMBL
| Assay Description
Displacement of [3H]nociceptin from human NOP receptor expressed in CHO-K1 cells by scintillation proximity assay |
ACS Med Chem Lett 5: 857-62 (2014)
Article DOI: 10.1021/ml500117c
BindingDB Entry DOI: 10.7270/Q25140ZK |
More data for this
Ligand-Target Pair | |
Mu-type opioid receptor
(Homo sapiens (Human)) | BDBM50101306
(CHEMBL3326229)Show SMILES Cl.CN(C)[C@]1(CC[C@@]2(CC1)N(C)CCc1c2[nH]c2ccccc12)c1ccccc1 |r,wU:4.2,wD:7.9,(35,-11.75,;25.44,-13.91,;23.96,-14.32,;22.86,-13.23,;23.56,-15.82,;22.79,-17.14,;21.26,-17.14,;20.5,-15.8,;21.26,-14.48,;22.8,-14.49,;19.59,-17.06,;20.22,-18.47,;18.05,-16.9,;17.42,-15.49,;18.33,-14.24,;19.87,-14.4,;20.5,-12.99,;19.35,-11.95,;19.35,-10.4,;18.01,-9.64,;16.68,-10.41,;16.68,-11.95,;18.01,-12.72,;25.1,-15.82,;25.86,-17.16,;27.4,-17.17,;28.18,-15.84,;27.4,-14.5,;25.87,-14.5,)| | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 0.240 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmacokinetics
Curated by ChEMBL
| Assay Description
Displacement of [3H]naloxone from human MOP receptor expressed in CHO-K1 cells by scintillation proximity assay |
ACS Med Chem Lett 5: 857-62 (2014)
Article DOI: 10.1021/ml500117c
BindingDB Entry DOI: 10.7270/Q25140ZK |
More data for this
Ligand-Target Pair | |
Mu-type opioid receptor
(Homo sapiens (Human)) | BDBM50100983
(CHEMBL3326224)Show SMILES Cl.CN(C)[C@]1(CC[C@@]2(CC1)OCCc1c2[nH]c2ccccc12)c1ccccc1 |r,wU:4.2,wD:7.9,(22.71,-7.97,;18.3,-7.93,;16.96,-7.16,;16.96,-5.62,;15.63,-7.93,;14.86,-9.26,;13.32,-9.27,;12.55,-7.94,;13.32,-6.61,;14.86,-6.6,;11.79,-9.28,;10.25,-9.27,;9.47,-7.94,;10.25,-6.6,;11.79,-6.61,;12.26,-5.14,;11.03,-4.24,;10.87,-2.7,;9.47,-2.07,;8.21,-2.98,;8.37,-4.51,;9.77,-5.14,;16.43,-9.25,;15.68,-10.6,;16.48,-11.91,;18.02,-11.88,;18.76,-10.52,;17.96,-9.21,)| | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.260 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmacokinetics
Curated by ChEMBL
| Assay Description
Displacement of [3H]naloxone from human MOP receptor expressed in CHO-K1 cells by scintillation proximity assay |
ACS Med Chem Lett 5: 857-62 (2014)
Article DOI: 10.1021/ml500117c
BindingDB Entry DOI: 10.7270/Q25140ZK |
More data for this
Ligand-Target Pair | |
Opioid growth factor receptor-like protein 1
(Homo sapiens (Human)) | BDBM177911
(US9120797, 10 | US9120797, 9)Show SMILES CN(C)C1(CCC2(CC1)NCCc1c2[nH]c2ccccc12)c1ccccc1 |(4.75,-.24,;3.27,.16,;2.87,1.65,;2.18,-.93,;1.41,-2.26,;-.13,-2.26,;-.9,-.93,;-.13,.4,;1.41,.4,;-1.67,-2.26,;-3.21,-2.26,;-3.98,-.93,;-3.21,.4,;-1.67,.4,;-1.2,1.87,;-2.44,2.77,;-2.6,4.3,;-4.01,4.93,;-5.26,4.03,;-5.1,2.49,;-3.69,1.87,;2.95,-2.26,;2.18,-3.6,;2.95,-4.93,;4.49,-4.93,;5.26,-3.6,;4.49,-2.26,)| Show InChI InChI=1S/C24H29N3/c1-27(2)24(18-8-4-3-5-9-18)15-13-23(14-16-24)22-20(12-17-25-23)19-10-6-7-11-21(19)26-22/h3-11,25-26H,12-17H2,1-2H3 | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| 0.260 | -54.7 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
Gruenenthal GmbH
US Patent
| Assay Description
The cyclohexane derivatives of the general formula I were investigated in a receptor binding assay with 3H-nociceptin/orphanin FQ with membranes from... |
US Patent US9120797 (2015)
BindingDB Entry DOI: 10.7270/Q2X065T3 |
More data for this
Ligand-Target Pair | |
Nociceptin receptor
(Homo sapiens (Human)) | BDBM469350
(US10807988, Example SC_3001 | cis-5-[1-(Cyclobutyl...)Show SMILES CN(C)[C@]1(CC[C@]2(CN(C(=O)N2CC2CCC2)c2cnc(nc2)C#N)CC1)c1ccccc1 |r,wU:6.11,3.2,(6.58,22.67,;5.1,23.06,;4.7,24.55,;4.01,21.98,;3.24,20.64,;1.7,20.64,;.93,21.98,;.02,23.22,;-1.44,22.75,;-1.44,21.21,;-2.69,20.3,;.02,20.73,;.5,19.26,;-.53,18.12,;-2.07,18.12,;-2.07,16.58,;-.53,16.58,;-2.69,23.65,;-2.53,25.18,;-3.77,26.09,;-5.18,25.46,;-5.34,23.93,;-4.1,23.02,;-6.43,26.37,;-7.67,27.27,;1.7,23.31,;3.24,23.31,;5.1,20.89,;4.7,19.4,;5.79,18.31,;7.27,18.71,;7.67,20.2,;6.58,21.28,)| Show InChI InChI=1S/C26H32N6O/c1-30(2)26(21-9-4-3-5-10-21)13-11-25(12-14-26)19-31(22-16-28-23(15-27)29-17-22)24(33)32(25)18-20-7-6-8-20/h3-5,9-10,16-17,20H,6-8,11-14,18-19H2,1-2H3/t25-,26+ | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| 0.300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Grünenthal GmbH
US Patent
| Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M... |
US Patent US10807988 (2020)
BindingDB Entry DOI: 10.7270/Q25Q5060 |
More data for this
Ligand-Target Pair | |
Opioid growth factor receptor-like protein 1
(Homo sapiens (Human)) | BDBM177903
(US9120797, 1 | US9120797, 2 | US9120797, 3)Show SMILES CN(C)C1(CCC2(CC1)OCCc1c2[nH]c2ccccc12)c1ccccc1 |(4.75,-.24,;3.27,.16,;2.87,1.65,;2.18,-.93,;1.41,-2.26,;-.13,-2.26,;-.9,-.93,;-.13,.4,;1.41,.4,;-1.67,-2.26,;-3.21,-2.26,;-3.98,-.93,;-3.21,.4,;-1.67,.4,;-1.2,1.87,;-2.44,2.77,;-2.6,4.3,;-4.01,4.93,;-5.26,4.03,;-5.1,2.49,;-3.69,1.87,;2.95,-2.26,;2.18,-3.6,;2.95,-4.93,;4.49,-4.93,;5.26,-3.6,;4.49,-2.26,)| Show InChI InChI=1S/C24H28N2O/c1-26(2)23(18-8-4-3-5-9-18)13-15-24(16-14-23)22-20(12-17-27-24)19-10-6-7-11-21(19)25-22/h3-11,25H,12-17H2,1-2H3 | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| 0.300 | -54.4 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
Gruenenthal GmbH
US Patent
| Assay Description
The cyclohexane derivatives of the general formula I were investigated in a receptor binding assay with 3H-nociceptin/orphanin FQ with membranes from... |
US Patent US9120797 (2015)
BindingDB Entry DOI: 10.7270/Q2X065T3 |
More data for this
Ligand-Target Pair | |
Mu-type opioid receptor
(Homo sapiens (Human)) | BDBM50101088
(CHEMBL3326220)Show SMILES Cl.CN(C)[C@]1(CC[C@@H](CC1)NC(=O)CCC1CCCC1)c1ccccc1 |r,wU:4.2,wD:7.9,(15.72,-29.86,;12.69,-28.26,;11.36,-27.5,;11.36,-25.96,;10.03,-28.27,;9.26,-29.6,;7.72,-29.6,;6.95,-28.28,;7.71,-26.95,;9.25,-26.94,;5.41,-28.28,;4.63,-26.95,;5.4,-25.61,;3.1,-26.95,;2.33,-25.61,;.79,-25.61,;-.11,-24.36,;-1.58,-24.83,;-1.58,-26.37,;-.12,-26.85,;10.82,-29.59,;10.08,-30.93,;10.87,-32.25,;12.41,-32.22,;13.16,-30.86,;12.36,-29.55,)| Show InChI InChI=1S/C22H34N2O/c1-24(2)22(19-10-4-3-5-11-19)16-14-20(15-17-22)23-21(25)13-12-18-8-6-7-9-18/h3-5,10-11,18,20H,6-9,12-17H2,1-2H3,(H,23,25)/t20-,22- | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmacokinetics
Curated by ChEMBL
| Assay Description
Displacement of [3H]Naloxone from human mu opioid receptor receptor expressed in CHO-K1 cells after 90 mins |
ACS Med Chem Lett 5: 851-6 (2014)
Article DOI: 10.1021/ml500116x
BindingDB Entry DOI: 10.7270/Q28S4RPM |
More data for this
Ligand-Target Pair | |
Nociceptin receptor
(Homo sapiens (Human)) | BDBM50100983
(CHEMBL3326224)Show SMILES Cl.CN(C)[C@]1(CC[C@@]2(CC1)OCCc1c2[nH]c2ccccc12)c1ccccc1 |r,wU:4.2,wD:7.9,(22.71,-7.97,;18.3,-7.93,;16.96,-7.16,;16.96,-5.62,;15.63,-7.93,;14.86,-9.26,;13.32,-9.27,;12.55,-7.94,;13.32,-6.61,;14.86,-6.6,;11.79,-9.28,;10.25,-9.27,;9.47,-7.94,;10.25,-6.6,;11.79,-6.61,;12.26,-5.14,;11.03,-4.24,;10.87,-2.7,;9.47,-2.07,;8.21,-2.98,;8.37,-4.51,;9.77,-5.14,;16.43,-9.25,;15.68,-10.6,;16.48,-11.91,;18.02,-11.88,;18.76,-10.52,;17.96,-9.21,)| | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmacokinetics
Curated by ChEMBL
| Assay Description
Displacement of [3H]nociceptin from human NOP receptor expressed in CHO-K1 cells after 90 mins |
ACS Med Chem Lett 5: 851-6 (2014)
Article DOI: 10.1021/ml500116x
BindingDB Entry DOI: 10.7270/Q28S4RPM |
More data for this
Ligand-Target Pair | |
Mu-type opioid receptor
(Homo sapiens (Human)) | BDBM239934
(US9403767, 117)Show SMILES CN(C)C1(CCC(CC1)(N(C)C(=O)c1cccc(F)c1)c1ccccc1)c1ccccc1 |(-6.07,4.12,;-5.44,2.71,;-3.93,3.03,;-5.44,1.17,;-6.26,-.13,;-5.53,-1.49,;-3.99,-1.55,;-3.18,-.24,;-3.9,1.12,;-3.99,-3.09,;-3.37,-4.49,;-5.33,-3.86,;-6.66,-3.09,;-5.33,-5.4,;-6.66,-6.17,;-6.66,-7.71,;-5.33,-8.48,;-3.99,-7.71,;-2.66,-8.48,;-3.99,-6.17,;-2.72,-2.41,;-1.33,-1.73,;-.06,-2.6,;-.16,-4.13,;-1.55,-4.81,;-2.82,-3.95,;-6.72,2.03,;-8.1,1.36,;-9.38,2.22,;-9.27,3.76,;-7.88,4.43,;-6.61,3.57,)| Show InChI InChI=1S/C28H31FN2O/c1-30(2)27(23-12-6-4-7-13-23)17-19-28(20-18-27,24-14-8-5-9-15-24)31(3)26(32)22-11-10-16-25(29)21-22/h4-16,21H,17-20H2,1-3H3 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| 0.350 | -54.0 | n/a | n/a | n/a | n/a | n/a | n/a | 25 |
GRUENENTHAL GMBH
US Patent
| Assay Description
The affinity to the human μ-opiate receptor was determined in a homogeneous preparation in microtiter plates. For this, dilution series of the res... |
US Patent US9403767 (2016)
BindingDB Entry DOI: 10.7270/Q23R0RSJ |
More data for this
Ligand-Target Pair | |
Mu-type opioid receptor
(Homo sapiens (Human)) | BDBM50101152
(CHEMBL3326232)Show SMILES OC(=O)CC(O)(CC(O)=O)C(O)=O.CN[C@]1(CC[C@@]2(CC1)OCCc1c2[nH]c2ccccc12)c1ccccc1 |r,wU:15.13,wD:18.20,(20.04,-1.08,;21.36,-1.84,;22.69,-1.08,;21.36,-3.37,;20.04,-4.13,;18.72,-3.37,;20.8,-5.45,;22.32,-5.46,;23.08,-6.78,;23.09,-4.13,;19.28,-5.45,;20.04,-6.77,;17.75,-5.44,;8.07,-7.76,;9.17,-8.84,;8.78,-10.34,;8,-11.67,;6.47,-11.66,;5.71,-10.33,;6.47,-9,;8.01,-9.01,;4.8,-11.59,;3.25,-11.43,;2.63,-10.01,;3.53,-8.77,;5.08,-8.93,;5.71,-7.51,;4.56,-6.48,;4.56,-4.92,;3.22,-4.16,;1.88,-4.93,;1.88,-6.48,;3.22,-7.25,;10.31,-10.35,;11.08,-11.69,;12.62,-11.7,;13.4,-10.37,;12.62,-9.02,;11.08,-9.02,)| Show InChI InChI=1S/C23H26N2O.C6H8O7/c1-24-22(17-7-3-2-4-8-17)12-14-23(15-13-22)21-19(11-16-26-23)18-9-5-6-10-20(18)25-21;7-3(8)1-6(13,5(11)12)2-4(9)10/h2-10,24-25H,11-16H2,1H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/t22-,23-; | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.360 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmacokinetics
Curated by ChEMBL
| Assay Description
Displacement of [3H]naloxone from human MOP receptor expressed in CHO-K1 cells by scintillation proximity assay |
ACS Med Chem Lett 5: 857-62 (2014)
Article DOI: 10.1021/ml500117c
BindingDB Entry DOI: 10.7270/Q25140ZK |
More data for this
Ligand-Target Pair | |
Mu-type opioid receptor
(Homo sapiens (Human)) | BDBM177911
(US9120797, 10 | US9120797, 9)Show SMILES CN(C)C1(CCC2(CC1)NCCc1c2[nH]c2ccccc12)c1ccccc1 |(4.75,-.24,;3.27,.16,;2.87,1.65,;2.18,-.93,;1.41,-2.26,;-.13,-2.26,;-.9,-.93,;-.13,.4,;1.41,.4,;-1.67,-2.26,;-3.21,-2.26,;-3.98,-.93,;-3.21,.4,;-1.67,.4,;-1.2,1.87,;-2.44,2.77,;-2.6,4.3,;-4.01,4.93,;-5.26,4.03,;-5.1,2.49,;-3.69,1.87,;2.95,-2.26,;2.18,-3.6,;2.95,-4.93,;4.49,-4.93,;5.26,-3.6,;4.49,-2.26,)| Show InChI InChI=1S/C24H29N3/c1-27(2)24(18-8-4-3-5-9-18)15-13-23(14-16-24)22-20(12-17-25-23)19-10-6-7-11-21(19)26-22/h3-11,25-26H,12-17H2,1-2H3 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| 0.360 | -53.9 | n/a | n/a | n/a | n/a | n/a | n/a | 25 |
Gruenenthal GmbH
US Patent
| Assay Description
The receptor affinity for the human mu-opiate receptor was determined in a homogeneous batch in microtitre plates. For this, dilution series of the p... |
US Patent US9120797 (2015)
BindingDB Entry DOI: 10.7270/Q2X065T3 |
More data for this
Ligand-Target Pair | |
Mu-type opioid receptor
(Homo sapiens (Human)) | BDBM50101099
(CHEMBL3326228)Show SMILES Cl.CN(C)[C@]1(CC[C@@]2(CC1)NCCc1c2[nH]c2ccccc12)c1ccccc1 |r,wU:4.2,wD:7.9,(19.24,-9.37,;10.32,-12.36,;8.84,-12.77,;7.74,-11.68,;8.44,-14.27,;7.67,-15.59,;6.14,-15.59,;5.38,-14.26,;6.14,-12.93,;7.68,-12.94,;4.47,-15.52,;2.93,-15.35,;2.3,-13.94,;3.21,-12.69,;4.75,-12.85,;5.38,-11.44,;4.23,-10.41,;4.23,-8.85,;2.89,-8.09,;1.56,-8.86,;1.56,-10.41,;2.89,-11.18,;9.98,-14.28,;10.74,-15.62,;12.28,-15.63,;13.06,-14.29,;12.29,-12.95,;10.75,-12.95,)| | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.390 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmacokinetics
Curated by ChEMBL
| Assay Description
Displacement of [3H]naloxone from human MOP receptor expressed in CHO-K1 cells by scintillation proximity assay |
ACS Med Chem Lett 5: 857-62 (2014)
Article DOI: 10.1021/ml500117c
BindingDB Entry DOI: 10.7270/Q25140ZK |
More data for this
Ligand-Target Pair | |
Nociceptin receptor
(Homo sapiens (Human)) | BDBM469352
(US10807988, Example SC_3003 | cis-5-[1-(Cyclobutyl...)Show SMILES COc1nc(ncc1N1C[C@]2(CC[C@@](CC2)(N(C)C)c2ccccc2)N(CC2CCC2)C1=O)C#N |r,wU:10.27,13.17,(-.93,-.89,;-.93,-2.43,;-2.26,-3.2,;-3.6,-2.43,;-4.93,-3.2,;-4.93,-4.74,;-3.6,-5.51,;-2.26,-4.74,;-.93,-5.51,;.53,-5.03,;1.44,-6.28,;2.21,-7.61,;3.75,-7.61,;4.52,-6.28,;3.75,-4.94,;2.21,-4.94,;5.29,-4.94,;6.83,-4.94,;4.52,-3.61,;5.29,-7.61,;4.52,-8.95,;5.29,-10.28,;6.83,-10.28,;7.6,-8.95,;6.83,-7.61,;.53,-7.52,;1.01,-8.99,;-.02,-10.13,;-1.56,-10.13,;-1.56,-11.67,;-.02,-11.67,;-.93,-7.05,;-2.18,-7.95,;-6.27,-2.43,;-7.6,-1.66,)| Show InChI InChI=1S/C27H34N6O2/c1-31(2)27(21-10-5-4-6-11-21)14-12-26(13-15-27)19-32(25(34)33(26)18-20-8-7-9-20)22-17-29-23(16-28)30-24(22)35-3/h4-6,10-11,17,20H,7-9,12-15,18-19H2,1-3H3/t26-,27+ | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| 0.400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Grünenthal GmbH
US Patent
| Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M... |
US Patent US10807988 (2020)
BindingDB Entry DOI: 10.7270/Q25Q5060 |
More data for this
Ligand-Target Pair | |
Mu-type opioid receptor
(Homo sapiens (Human)) | BDBM239911
(US9403767, 76 | US9403767, 77)Show SMILES CN(CC1(C)CCC(CC1)(N(C)C)c1ccccc1)c1c[nH]c2ccccc12 |(2.68,2.55,;1.65,1.41,;.14,1.73,;-.33,3.19,;-1.28,1.98,;-1.51,4.18,;-1.24,5.7,;.2,6.23,;1.38,5.24,;1.11,3.72,;1.15,7.44,;2.68,7.22,;1.52,8.93,;-.27,7.69,;-1.78,8.01,;-2.26,9.48,;-1.23,10.62,;.28,10.3,;.76,8.83,;2.13,-.06,;1.22,-1.3,;2.13,-2.55,;3.59,-2.07,;4.92,-2.84,;6.26,-2.07,;6.26,-.53,;4.92,.24,;3.59,-.53,)| Show InChI InChI=1S/C25H33N3/c1-24(19-28(4)23-18-26-22-13-9-8-12-21(22)23)14-16-25(17-15-24,27(2)3)20-10-6-5-7-11-20/h5-13,18,26H,14-17,19H2,1-4H3 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| 0.400 | -53.6 | n/a | n/a | n/a | n/a | n/a | n/a | 25 |
GRUENENTHAL GMBH
US Patent
| Assay Description
The affinity to the human μ-opiate receptor was determined in a homogeneous preparation in microtiter plates. For this, dilution series of the res... |
US Patent US9403767 (2016)
BindingDB Entry DOI: 10.7270/Q23R0RSJ |
More data for this
Ligand-Target Pair | |
Mu-type opioid receptor
(Homo sapiens (Human)) | BDBM50101096
(CHEMBL3325961)Show SMILES OC(=O)CC(O)(CC(O)=O)C(O)=O.CN(C)[C@]1(CC[C@@]2(CC1)OCCc1c2[nH]c2ccc(O)cc12)c1ccccc1 |r,wU:16.14,wD:19.21,(26.19,-30.17,;27.51,-30.93,;28.83,-30.17,;27.51,-32.46,;26.19,-33.22,;24.86,-32.46,;26.94,-34.54,;28.47,-34.55,;29.23,-35.87,;29.24,-33.23,;25.42,-34.54,;26.18,-35.86,;23.89,-34.53,;16.55,-35.59,;17.65,-36.68,;19.13,-36.27,;17.25,-38.18,;16.48,-39.51,;14.95,-39.5,;14.18,-38.17,;14.95,-36.84,;16.49,-36.85,;13.27,-39.43,;11.73,-39.27,;11.1,-37.85,;12.01,-36.6,;13.55,-36.76,;14.18,-35.35,;13.04,-34.31,;13.03,-32.76,;11.69,-31.99,;10.36,-32.76,;9.02,-31.99,;10.36,-34.31,;11.69,-35.08,;18.79,-38.19,;19.55,-39.53,;21.1,-39.54,;21.87,-38.2,;21.1,-36.86,;19.56,-36.86,)| | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| 0.400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmacokinetics
Curated by ChEMBL
| Assay Description
Displacement of [3H]naloxone from human MOP receptor expressed in CHO-K1 cells by scintillation proximity assay |
ACS Med Chem Lett 5: 857-62 (2014)
Article DOI: 10.1021/ml500117c
BindingDB Entry DOI: 10.7270/Q25140ZK |
More data for this
Ligand-Target Pair | |
Nociceptin receptor
(Homo sapiens (Human)) | BDBM469875
(CIS-2-[1-(Cyclobutyl-methyl)-8-dimethylamino-2-oxo...)Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC(=O)NCc3ccccc3C)C(=O)N2CC2CCC2)CC1)c1ccccc1 |r,wU:6.24,3.2,(-7.28,-9.36,;-6.19,-10.44,;-4.7,-10.05,;-6.59,-11.93,;-6.59,-13.47,;-7.92,-14.24,;-9.26,-13.47,;-10.55,-12.63,;-11.75,-13.6,;-13.23,-13.2,;-14.32,-14.29,;-13.92,-15.78,;-15.81,-13.89,;-16.9,-14.98,;-18.39,-14.58,;-19.47,-15.67,;-20.96,-15.27,;-21.36,-13.79,;-20.27,-12.7,;-18.78,-13.1,;-17.7,-12.01,;-11.19,-15.04,;-11.96,-16.37,;-9.66,-14.96,;-8.57,-16.05,;-8.97,-17.54,;-10.3,-18.31,;-9.53,-19.64,;-8.2,-18.87,;-9.26,-11.93,;-7.92,-11.16,;-5.1,-12.33,;-4.7,-13.82,;-3.22,-14.22,;-2.13,-13.13,;-2.53,-11.64,;-4.01,-11.24,)| Show InChI InChI=1S/C31H42N4O2/c1-24-10-7-8-13-26(24)20-32-28(36)22-34-23-30(35(29(34)37)21-25-11-9-12-25)16-18-31(19-17-30,33(2)3)27-14-5-4-6-15-27/h4-8,10,13-15,25H,9,11-12,16-23H2,1-3H3,(H,32,36)/t30-,31+ | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| 0.400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GRÜNENTHAL GMBH
US Patent
| Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl, 10 mM M... |
US Patent US10807989 (2020)
BindingDB Entry DOI: 10.7270/Q2222XTM |
More data for this
Ligand-Target Pair | |
Nociceptin receptor
(Homo sapiens (Human)) | BDBM464662
(CIS-1-(Cyclopropyl-methyl)-8-dimethylamino-8-pheny...)Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC(C)(C)N3CCCS3(=O)=O)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1 |r,wU:6.23,3.2,(5.39,-23.23,;3.85,-23.23,;3.08,-21.9,;3.08,-24.57,;2.31,-25.9,;.77,-25.9,;-0,-24.57,;-.91,-23.32,;-2.37,-23.8,;-3.71,-23.03,;-5.04,-23.8,;-5.81,-25.13,;-4.27,-25.13,;-6.37,-23.03,;-7.84,-23.5,;-8.74,-22.26,;-7.84,-21.01,;-6.37,-21.49,;-6.37,-19.95,;-4.89,-21.09,;-2.37,-25.34,;-3.62,-26.24,;-.91,-25.81,;-.43,-27.28,;-1.46,-28.42,;.03,-28.82,;-3,-28.42,;-3,-29.96,;-1.46,-29.96,;.77,-23.23,;2.31,-23.23,;3.85,-25.9,;3.08,-27.23,;3.85,-28.57,;5.39,-28.57,;6.16,-27.23,;5.39,-25.9,)| Show InChI InChI=1S/C28H44N4O4S/c1-25(2,32-18-9-19-37(32,35)36)20-30-21-26(31(24(30)33)22-27(34)12-8-13-27)14-16-28(17-15-26,29(3)4)23-10-6-5-7-11-23/h5-7,10-11,34H,8-9,12-22H2,1-4H3/t26-,28+ | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| 0.400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GRUENENTHAL GMBH
US Patent
| Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M... |
US Patent US10793556 (2020)
BindingDB Entry DOI: 10.7270/Q2XK8JMK |
More data for this
Ligand-Target Pair | |
Nociceptin receptor
(Homo sapiens (Human)) | BDBM50101091
(CHEMBL3326223)Show SMILES Cl.Cl.CN(C)[C@]1(CC[C@@H](CC1)NCCc1c[nH]c2ccc(F)cc12)c1ccccc1 |r,wU:5.2,wD:8.9,(50.15,-23.7,;44.1,-26.45,;47.35,-21.61,;46.01,-20.85,;46.01,-19.3,;44.68,-21.62,;43.91,-22.95,;42.37,-22.95,;41.6,-21.63,;42.36,-20.29,;43.9,-20.29,;40.06,-21.63,;39.26,-22.95,;37.72,-22.91,;36.92,-24.23,;37.52,-25.66,;36.35,-26.66,;35.03,-25.86,;33.57,-26.31,;32.44,-25.27,;32.79,-23.76,;31.66,-22.71,;34.26,-23.31,;35.38,-24.36,;45.47,-22.94,;44.73,-24.28,;45.53,-25.6,;47.07,-25.57,;47.81,-24.21,;47.01,-22.9,)| | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmacokinetics
Curated by ChEMBL
| Assay Description
Displacement of [3H]nociceptin from human NOP receptor expressed in CHO-K1 cells after 90 mins |
ACS Med Chem Lett 5: 851-6 (2014)
Article DOI: 10.1021/ml500116x
BindingDB Entry DOI: 10.7270/Q28S4RPM |
More data for this
Ligand-Target Pair | |
Nociceptin receptor
(Homo sapiens (Human)) | BDBM469376
(US10807988, Example SC_3022 | cis-1-(Cyclobutyl-me...)Show SMILES CN(C)[C@]1(CC[C@]2(CN(C(=O)N2CC2CCC2)c2cnc(nc2)C(F)(F)F)CC1)c1ccccc1 |r,wU:6.11,3.2,(4.39,8.81,;5.16,7.47,;6.7,7.47,;4.39,6.14,;3.62,4.81,;2.08,4.81,;1.31,6.14,;.41,7.38,;-1.06,6.91,;-1.06,5.37,;-2.31,4.46,;.41,4.89,;.88,3.43,;-.15,2.28,;-1.69,2.28,;-1.69,.74,;-.15,.74,;-2.39,7.68,;-2.39,9.22,;-3.73,9.99,;-5.06,9.22,;-5.06,7.68,;-3.73,6.91,;-6.39,9.99,;-7.73,9.22,;-6.39,11.53,;-7.73,10.76,;2.08,7.47,;3.62,7.47,;5.16,4.81,;4.39,3.47,;5.16,2.14,;6.7,2.14,;7.47,3.47,;6.7,4.81,)| Show InChI InChI=1S/C26H32F3N5O/c1-32(2)25(20-9-4-3-5-10-20)13-11-24(12-14-25)18-33(23(35)34(24)17-19-7-6-8-19)21-15-30-22(31-16-21)26(27,28)29/h3-5,9-10,15-16,19H,6-8,11-14,17-18H2,1-2H3/t24-,25+ | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| 0.400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Grünenthal GmbH
US Patent
| Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M... |
US Patent US10807988 (2020)
BindingDB Entry DOI: 10.7270/Q25Q5060 |
More data for this
Ligand-Target Pair | |
Mu-type opioid receptor
(Homo sapiens (Human)) | BDBM472033
(US10829480, Example SC_2061)Show SMILES CN(C)[C@]1(CC[C@]2(CN(Cc3cccnc3)C(=O)N2CC2CCC2)CC1)c1ccccc1 |r,wU:6.19,3.2,(-9.65,-1.19,;-8.88,-2.52,;-7.34,-2.52,;-9.65,-3.86,;-10.42,-5.19,;-11.96,-5.19,;-12.73,-3.86,;-13.63,-2.61,;-15.09,-3.09,;-16.43,-2.32,;-17.76,-3.09,;-19.1,-2.32,;-20.43,-3.09,;-20.43,-4.63,;-19.1,-5.4,;-17.76,-4.63,;-15.09,-4.63,;-16.43,-5.4,;-13.63,-5.1,;-13.23,-6.59,;-14.32,-7.68,;-15.86,-7.68,;-15.86,-9.22,;-14.32,-9.22,;-11.96,-2.52,;-10.42,-2.52,;-8.88,-5.19,;-9.65,-6.52,;-8.88,-7.86,;-7.34,-7.86,;-6.57,-6.52,;-7.34,-5.19,)| Show InChI InChI=1S/C27H36N4O/c1-29(2)27(24-11-4-3-5-12-24)15-13-26(14-16-27)21-30(19-23-10-7-17-28-18-23)25(32)31(26)20-22-8-6-9-22/h3-5,7,10-12,17-18,22H,6,8-9,13-16,19-21H2,1-2H3/t26-,27+ | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| 0.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GRUENENTHAL GMBH
US Patent
| Assay Description
Mu-Opioid Peptide (hMOP): The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buff... |
US Patent US10829480 (2020)
BindingDB Entry DOI: 10.7270/Q2SB48SB |
More data for this
Ligand-Target Pair | |
Opioid growth factor receptor-like protein 1
(Homo sapiens (Human)) | BDBM177935
(US9120797, 33)Show SMILES CC1Cc2c([nH]c3ccccc23)C2(CCC(CC2)(N(C)C)c2ccccc2)N1 |(-3.98,-3.6,;-3.21,-2.26,;-3.98,-.93,;-3.21,.4,;-1.67,.4,;-1.2,1.87,;-2.44,2.77,;-2.6,4.3,;-4.01,4.93,;-5.26,4.03,;-5.1,2.49,;-3.69,1.87,;-.9,-.93,;-.13,-2.26,;1.41,-2.26,;2.18,-.93,;1.41,.4,;-.13,.4,;3.27,.16,;4.75,-.24,;2.87,1.65,;2.95,-2.26,;2.18,-3.6,;2.95,-4.93,;4.49,-4.93,;5.26,-3.6,;4.49,-2.26,;-1.67,-2.26,)| | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| 0.5 | -53.1 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
Gruenenthal GmbH
US Patent
| Assay Description
The cyclohexane derivatives of the general formula I were investigated in a receptor binding assay with 3H-nociceptin/orphanin FQ with membranes from... |
US Patent US9120797 (2015)
BindingDB Entry DOI: 10.7270/Q2X065T3 |
More data for this
Ligand-Target Pair | |
Mu-type opioid receptor
(Homo sapiens (Human)) | BDBM177935
(US9120797, 33)Show SMILES CC1Cc2c([nH]c3ccccc23)C2(CCC(CC2)(N(C)C)c2ccccc2)N1 |(-3.98,-3.6,;-3.21,-2.26,;-3.98,-.93,;-3.21,.4,;-1.67,.4,;-1.2,1.87,;-2.44,2.77,;-2.6,4.3,;-4.01,4.93,;-5.26,4.03,;-5.1,2.49,;-3.69,1.87,;-.9,-.93,;-.13,-2.26,;1.41,-2.26,;2.18,-.93,;1.41,.4,;-.13,.4,;3.27,.16,;4.75,-.24,;2.87,1.65,;2.95,-2.26,;2.18,-3.6,;2.95,-4.93,;4.49,-4.93,;5.26,-3.6,;4.49,-2.26,;-1.67,-2.26,)| | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| 0.5 | -53.1 | n/a | n/a | n/a | n/a | n/a | n/a | 25 |
Gruenenthal GmbH
US Patent
| Assay Description
The receptor affinity for the human mu-opiate receptor was determined in a homogeneous batch in microtitre plates. For this, dilution series of the p... |
US Patent US9120797 (2015)
BindingDB Entry DOI: 10.7270/Q2X065T3 |
More data for this
Ligand-Target Pair | |
Nociceptin receptor
(Homo sapiens (Human)) | BDBM469999
(CIS-2-[1-(Cyclobutyl-methyl)-8-dimethylamino-2-oxo...)Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC(=O)Nc3cncnc3)C(=O)N2CC2CCC2)CC1)c1ccccc1 |r,wU:6.22,3.2,(-4.1,21.01,;-5.59,21.41,;-5.99,22.9,;-6.68,20.32,;-7.45,18.99,;-8.99,18.99,;-9.76,20.32,;-10.67,21.57,;-12.13,21.09,;-13.22,22.18,;-14.71,21.78,;-15.11,20.3,;-15.8,22.87,;-17.28,22.47,;-17.68,20.99,;-19.17,20.59,;-20.26,21.68,;-19.86,23.16,;-18.37,23.56,;-12.13,19.55,;-13.46,18.78,;-10.67,19.08,;-9.9,17.74,;-10.67,16.41,;-12.15,16.01,;-11.76,14.52,;-10.27,14.92,;-8.99,21.66,;-7.45,21.66,;-5.59,19.23,;-5.99,17.75,;-4.9,16.66,;-3.41,17.06,;-3.02,18.54,;-4.1,19.63,)| Show InChI InChI=1S/C27H36N6O2/c1-31(2)27(22-9-4-3-5-10-22)13-11-26(12-14-27)19-32(25(35)33(26)17-21-7-6-8-21)18-24(34)30-23-15-28-20-29-16-23/h3-5,9-10,15-16,20-21H,6-8,11-14,17-19H2,1-2H3,(H,30,34)/t26-,27+ | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| 0.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GRÜNENTHAL GMBH
US Patent
| Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl, 10 mM M... |
US Patent US10807989 (2020)
BindingDB Entry DOI: 10.7270/Q2222XTM |
More data for this
Ligand-Target Pair | |
Prepronociceptin
(Human) | BDBM464503
(US10793528, Example SC_5078)Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC(C)(C)C(N)=O)C(=O)N2CC2(CCC2)C#N)CC1)c1ccccc1 |r,wU:6.18,3.2,(4.48,3.79,;4.48,2.25,;5.9,1.66,;3.39,1.16,;2.62,-.18,;1.08,-.18,;.31,1.16,;-.59,2.4,;-2.06,1.93,;-3.39,2.7,;-4.73,1.93,;-5.5,.59,;-3.96,.59,;-6.06,2.7,;-7.39,1.93,;-6.06,4.24,;-2.06,.39,;-3.3,-.52,;-.59,-.09,;-.12,-1.55,;-1.15,-2.7,;-2.69,-2.7,;-2.69,-4.24,;-1.15,-4.24,;.34,-3.1,;1.83,-3.49,;1.08,2.49,;2.62,2.49,;4.73,.39,;4.73,-1.15,;6.06,-1.92,;7.39,-1.15,;7.39,.39,;6.06,1.16,)| Show InChI InChI=1S/C27H39N5O2/c1-24(2,22(29)33)18-31-20-26(32(23(31)34)19-25(17-28)11-8-12-25)13-15-27(16-14-26,30(3)4)21-9-6-5-7-10-21/h5-7,9-10H,8,11-16,18-20H2,1-4H3,(H2,29,33)/t26-,27+ | UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| 0.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GRÜNENTHAL GMBH
US Patent
| Assay Description
NOP:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 ... |
US Patent US10793528 (2020)
BindingDB Entry DOI: 10.7270/Q2Q243B2 |
More data for this
Ligand-Target Pair | |
Nociceptin receptor
(Homo sapiens (Human)) | BDBM50100991
(CHEMBL3325879)Show SMILES Cl.Cl.CN(C)[C@]1(CC[C@@H](CC1)NCCCc1ccccc1)c1ccccc1 |r,wU:5.2,wD:8.9,(20.29,-18.75,;12.97,-20.62,;17.61,-17.09,;16.27,-16.32,;16.27,-14.78,;14.94,-17.09,;14.17,-18.42,;12.63,-18.43,;11.86,-17.1,;12.62,-15.77,;14.17,-15.76,;10.32,-17.1,;9.56,-18.43,;8.02,-18.44,;7.26,-19.78,;5.72,-19.79,;4.95,-18.45,;3.41,-18.46,;2.64,-19.79,;3.42,-21.13,;4.96,-21.12,;15.74,-18.41,;14.99,-19.76,;15.79,-21.08,;17.33,-21.04,;18.07,-19.68,;17.27,-18.37,)| Show InChI InChI=1S/C23H32N2/c1-25(2)23(21-13-7-4-8-14-21)17-15-22(16-18-23)24-19-9-12-20-10-5-3-6-11-20/h3-8,10-11,13-14,22,24H,9,12,15-19H2,1-2H3/t22-,23- | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| 0.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmacokinetics
Curated by ChEMBL
| Assay Description
Displacement of [3H]nociceptin from human NOP receptor expressed in CHO-K1 cells after 90 mins |
ACS Med Chem Lett 5: 851-6 (2014)
Article DOI: 10.1021/ml500116x
BindingDB Entry DOI: 10.7270/Q28S4RPM |
More data for this
Ligand-Target Pair | |
Nociceptin receptor
(Homo sapiens (Human)) | BDBM50101088
(CHEMBL3326220)Show SMILES Cl.CN(C)[C@]1(CC[C@@H](CC1)NC(=O)CCC1CCCC1)c1ccccc1 |r,wU:4.2,wD:7.9,(15.72,-29.86,;12.69,-28.26,;11.36,-27.5,;11.36,-25.96,;10.03,-28.27,;9.26,-29.6,;7.72,-29.6,;6.95,-28.28,;7.71,-26.95,;9.25,-26.94,;5.41,-28.28,;4.63,-26.95,;5.4,-25.61,;3.1,-26.95,;2.33,-25.61,;.79,-25.61,;-.11,-24.36,;-1.58,-24.83,;-1.58,-26.37,;-.12,-26.85,;10.82,-29.59,;10.08,-30.93,;10.87,-32.25,;12.41,-32.22,;13.16,-30.86,;12.36,-29.55,)| Show InChI InChI=1S/C22H34N2O/c1-24(2)22(19-10-4-3-5-11-19)16-14-20(15-17-22)23-21(25)13-12-18-8-6-7-9-18/h3-5,10-11,18,20H,6-9,12-17H2,1-2H3,(H,23,25)/t20-,22- | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmacokinetics
Curated by ChEMBL
| Assay Description
Displacement of [3H]nociceptin from human NOP receptor expressed in CHO-K1 cells after 90 mins |
ACS Med Chem Lett 5: 851-6 (2014)
Article DOI: 10.1021/ml500116x
BindingDB Entry DOI: 10.7270/Q28S4RPM |
More data for this
Ligand-Target Pair | |
Nociceptin receptor
(Homo sapiens (Human)) | BDBM239921
(US9403767, 99)Show SMILES CN(C)C1(CCC(CC1)(N(C)C(=O)c1cccc(c1)C(F)(F)F)c1ccccc1)c1ccccc1 |(-.18,-1.04,;1.33,-.77,;1.86,.68,;2.32,-1.95,;3.66,-2.72,;3.66,-4.26,;2.32,-5.03,;.99,-4.26,;.99,-2.72,;3.05,-6.39,;3.15,-7.93,;4.59,-6.44,;5.4,-5.14,;5.31,-7.8,;4.49,-9.11,;5.22,-10.47,;6.75,-10.52,;7.57,-9.22,;6.85,-7.86,;9.11,-9.27,;10.65,-9.32,;9.16,-7.73,;9.06,-10.81,;1.6,-6.39,;2.42,-7.7,;1.69,-9.06,;.15,-9.11,;-.66,-7.8,;.06,-6.44,;3.31,-.77,;2.79,.68,;3.78,1.86,;5.29,1.59,;5.82,.14,;4.83,-1.04,)| Show InChI InChI=1S/C29H31F3N2O/c1-33(2)27(23-12-6-4-7-13-23)17-19-28(20-18-27,24-14-8-5-9-15-24)34(3)26(35)22-11-10-16-25(21-22)29(30,31)32/h4-16,21H,17-20H2,1-3H3 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| 0.540 | n/a | n/a | n/a | n/a | n/a | n/a | 7.4 | n/a |
GRUENENTHAL GMBH
US Patent
| Assay Description
The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste... |
US Patent US9403767 (2016)
BindingDB Entry DOI: 10.7270/Q23R0RSJ |
More data for this
Ligand-Target Pair | |
Nociceptin receptor
(Homo sapiens (Human)) | BDBM50101306
(CHEMBL3326229)Show SMILES Cl.CN(C)[C@]1(CC[C@@]2(CC1)N(C)CCc1c2[nH]c2ccccc12)c1ccccc1 |r,wU:4.2,wD:7.9,(35,-11.75,;25.44,-13.91,;23.96,-14.32,;22.86,-13.23,;23.56,-15.82,;22.79,-17.14,;21.26,-17.14,;20.5,-15.8,;21.26,-14.48,;22.8,-14.49,;19.59,-17.06,;20.22,-18.47,;18.05,-16.9,;17.42,-15.49,;18.33,-14.24,;19.87,-14.4,;20.5,-12.99,;19.35,-11.95,;19.35,-10.4,;18.01,-9.64,;16.68,-10.41,;16.68,-11.95,;18.01,-12.72,;25.1,-15.82,;25.86,-17.16,;27.4,-17.17,;28.18,-15.84,;27.4,-14.5,;25.87,-14.5,)| | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 0.550 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmacokinetics
Curated by ChEMBL
| Assay Description
Displacement of [3H]nociceptin from human NOP receptor expressed in CHO-K1 cells by scintillation proximity assay |
ACS Med Chem Lett 5: 857-62 (2014)
Article DOI: 10.1021/ml500117c
BindingDB Entry DOI: 10.7270/Q25140ZK |
More data for this
Ligand-Target Pair | |
Mu-type opioid receptor
(Homo sapiens (Human)) | BDBM50100983
(CHEMBL3326224)Show SMILES Cl.CN(C)[C@]1(CC[C@@]2(CC1)OCCc1c2[nH]c2ccccc12)c1ccccc1 |r,wU:4.2,wD:7.9,(22.71,-7.97,;18.3,-7.93,;16.96,-7.16,;16.96,-5.62,;15.63,-7.93,;14.86,-9.26,;13.32,-9.27,;12.55,-7.94,;13.32,-6.61,;14.86,-6.6,;11.79,-9.28,;10.25,-9.27,;9.47,-7.94,;10.25,-6.6,;11.79,-6.61,;12.26,-5.14,;11.03,-4.24,;10.87,-2.7,;9.47,-2.07,;8.21,-2.98,;8.37,-4.51,;9.77,-5.14,;16.43,-9.25,;15.68,-10.6,;16.48,-11.91,;18.02,-11.88,;18.76,-10.52,;17.96,-9.21,)| | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.600 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmacokinetics
Curated by ChEMBL
| Assay Description
Displacement of [3H]Naloxone from human mu opioid receptor receptor expressed in CHO-K1 cells after 90 mins |
ACS Med Chem Lett 5: 851-6 (2014)
Article DOI: 10.1021/ml500116x
BindingDB Entry DOI: 10.7270/Q28S4RPM |
More data for this
Ligand-Target Pair | |
Mu-type opioid receptor
(Homo sapiens (Human)) | BDBM177955
(US9120797, 53)Show SMILES CN(C)C1(Cc2ccccc2)CCC2(CC1)NCCc1c2[nH]c2ccccc12 |(3.6,-.91,;2.11,-.51,;1.71,.98,;1.02,-1.6,;1.79,-2.93,;3.33,-2.93,;4.1,-4.26,;5.64,-4.26,;6.41,-2.93,;5.64,-1.6,;4.1,-1.6,;.25,-2.93,;-1.29,-2.93,;-2.06,-1.6,;-1.29,-.26,;.25,-.26,;-2.83,-2.93,;-4.37,-2.93,;-5.14,-1.6,;-4.37,-.26,;-2.83,-.26,;-2.35,1.2,;-3.6,2.11,;-3.76,3.64,;-5.17,4.26,;-6.41,3.36,;-6.25,1.83,;-4.84,1.2,)| Show InChI InChI=1S/C25H31N3/c1-28(2)24(18-19-8-4-3-5-9-19)13-15-25(16-14-24)23-21(12-17-26-25)20-10-6-7-11-22(20)27-23/h3-11,26-27H,12-18H2,1-2H3 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| 0.600 | -52.6 | n/a | n/a | n/a | n/a | n/a | n/a | 25 |
Gruenenthal GmbH
US Patent
| Assay Description
The receptor affinity for the human mu-opiate receptor was determined in a homogeneous batch in microtitre plates. For this, dilution series of the p... |
US Patent US9120797 (2015)
BindingDB Entry DOI: 10.7270/Q2X065T3 |
More data for this
Ligand-Target Pair | |
Mu-type opioid receptor
(Homo sapiens (Human)) | BDBM177903
(US9120797, 1 | US9120797, 2 | US9120797, 3)Show SMILES CN(C)C1(CCC2(CC1)OCCc1c2[nH]c2ccccc12)c1ccccc1 |(4.75,-.24,;3.27,.16,;2.87,1.65,;2.18,-.93,;1.41,-2.26,;-.13,-2.26,;-.9,-.93,;-.13,.4,;1.41,.4,;-1.67,-2.26,;-3.21,-2.26,;-3.98,-.93,;-3.21,.4,;-1.67,.4,;-1.2,1.87,;-2.44,2.77,;-2.6,4.3,;-4.01,4.93,;-5.26,4.03,;-5.1,2.49,;-3.69,1.87,;2.95,-2.26,;2.18,-3.6,;2.95,-4.93,;4.49,-4.93,;5.26,-3.6,;4.49,-2.26,)| Show InChI InChI=1S/C24H28N2O/c1-26(2)23(18-8-4-3-5-9-18)13-15-24(16-14-23)22-20(12-17-27-24)19-10-6-7-11-21(19)25-22/h3-11,25H,12-17H2,1-2H3 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| 0.600 | -52.6 | n/a | n/a | n/a | n/a | n/a | n/a | 25 |
Gruenenthal GmbH
US Patent
| Assay Description
The receptor affinity for the human mu-opiate receptor was determined in a homogeneous batch in microtitre plates. For this, dilution series of the p... |
US Patent US9120797 (2015)
BindingDB Entry DOI: 10.7270/Q2X065T3 |
More data for this
Ligand-Target Pair | |
Opioid growth factor receptor-like protein 1
(Homo sapiens (Human)) | BDBM177903
(US9120797, 1 | US9120797, 2 | US9120797, 3)Show SMILES CN(C)C1(CCC2(CC1)OCCc1c2[nH]c2ccccc12)c1ccccc1 |(4.75,-.24,;3.27,.16,;2.87,1.65,;2.18,-.93,;1.41,-2.26,;-.13,-2.26,;-.9,-.93,;-.13,.4,;1.41,.4,;-1.67,-2.26,;-3.21,-2.26,;-3.98,-.93,;-3.21,.4,;-1.67,.4,;-1.2,1.87,;-2.44,2.77,;-2.6,4.3,;-4.01,4.93,;-5.26,4.03,;-5.1,2.49,;-3.69,1.87,;2.95,-2.26,;2.18,-3.6,;2.95,-4.93,;4.49,-4.93,;5.26,-3.6,;4.49,-2.26,)| Show InChI InChI=1S/C24H28N2O/c1-26(2)23(18-8-4-3-5-9-18)13-15-24(16-14-23)22-20(12-17-27-24)19-10-6-7-11-21(19)25-22/h3-11,25H,12-17H2,1-2H3 | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| 0.600 | -52.6 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
Gruenenthal GmbH
US Patent
| Assay Description
The cyclohexane derivatives of the general formula I were investigated in a receptor binding assay with 3H-nociceptin/orphanin FQ with membranes from... |
US Patent US9120797 (2015)
BindingDB Entry DOI: 10.7270/Q2X065T3 |
More data for this
Ligand-Target Pair | |
Nociceptin receptor
(Homo sapiens (Human)) | BDBM469437
(US10807988, Example SC_3078 | cis-5-[1-(Cyclobutyl...)Show SMILES CN(C)[C@]1(CC[C@]2(CN(C(=O)N2CC2CCC2)c2cnc(cc2C)C#N)CC1)c1ccccc1 |r,wU:6.11,3.2,(4.01,24.08,;4.78,22.75,;6.32,22.75,;4.01,21.41,;3.24,20.08,;1.7,20.08,;.93,21.41,;.03,22.66,;-1.44,22.18,;-1.44,20.64,;-2.68,19.74,;.03,20.17,;.5,18.7,;-.53,17.56,;-2.07,17.56,;-2.07,16.02,;-.53,16.02,;-2.53,23.27,;-4.01,22.87,;-5.1,23.96,;-4.7,25.45,;-3.22,25.85,;-2.13,24.76,;-.64,25.16,;-5.79,26.54,;-6.88,27.63,;1.7,22.75,;3.24,22.75,;4.78,20.08,;4.01,18.74,;4.78,17.41,;6.32,17.41,;7.09,18.74,;6.32,20.08,)| Show InChI InChI=1S/C28H35N5O/c1-21-16-24(17-29)30-18-25(21)32-20-27(33(26(32)34)19-22-8-7-9-22)12-14-28(15-13-27,31(2)3)23-10-5-4-6-11-23/h4-6,10-11,16,18,22H,7-9,12-15,19-20H2,1-3H3/t27-,28+ | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| 0.600 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Grünenthal GmbH
US Patent
| Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M... |
US Patent US10807988 (2020)
BindingDB Entry DOI: 10.7270/Q25Q5060 |
More data for this
Ligand-Target Pair | |
Nociceptin receptor
(Homo sapiens (Human)) | BDBM469435
(US10807988, Example SC_3076 | cis-1-(Cyclobutyl-me...)Show SMILES COc1ncc(cn1)N1C[C@]2(CC[C@@](CC2)(N(C)C)c2ccccc2)N(CC2CCC2)C1=O |r,wU:10.27,13.17,(-7.19,-2.27,;-5.7,-1.87,;-4.62,-2.96,;-3.13,-2.56,;-2.04,-3.65,;-2.44,-5.14,;-3.93,-5.54,;-5.01,-4.45,;-1.35,-6.23,;.12,-5.75,;1.02,-7,;1.79,-8.33,;3.33,-8.33,;4.1,-7,;3.33,-5.66,;1.79,-5.66,;4.87,-5.66,;4.1,-4.33,;6.41,-5.66,;4.87,-8.33,;4.1,-9.67,;4.87,-11,;6.41,-11,;7.18,-9.67,;6.41,-8.33,;.12,-8.24,;.59,-9.71,;-.44,-10.85,;-1.98,-10.85,;-1.98,-12.39,;-.44,-12.39,;-1.35,-7.77,;-2.59,-8.67,)| Show InChI InChI=1S/C26H35N5O2/c1-29(2)26(21-10-5-4-6-11-21)14-12-25(13-15-26)19-30(22-16-27-23(33-3)28-17-22)24(32)31(25)18-20-8-7-9-20/h4-6,10-11,16-17,20H,7-9,12-15,18-19H2,1-3H3/t25-,26+ | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| 0.600 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Grünenthal GmbH
US Patent
| Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M... |
US Patent US10807988 (2020)
BindingDB Entry DOI: 10.7270/Q25Q5060 |
More data for this
Ligand-Target Pair | |
Nociceptin receptor
(Homo sapiens (Human)) | BDBM469382
(US10807988, Example SC_3028 | cis-4-[1-(Cyclobutyl...)Show SMILES CN(C)C(=O)c1ccc(cc1)N1C[C@]2(CC[C@@](CC2)(N(C)C)c2ccccc2)N(CC2CCC2)C1=O |r,wU:13.30,16.20,(-8.08,-16.17,;-6.84,-17.07,;-7,-18.61,;-5.43,-16.45,;-5.27,-14.92,;-4.18,-17.35,;-2.78,-16.73,;-1.53,-17.63,;-1.69,-19.16,;-3.1,-19.79,;-4.35,-18.89,;-.45,-20.07,;1.02,-19.59,;1.92,-20.84,;2.69,-22.17,;4.23,-22.17,;5,-20.84,;4.23,-19.51,;2.69,-19.51,;5.77,-19.51,;5,-18.17,;7.31,-19.51,;5.77,-22.17,;5,-23.51,;5.77,-24.84,;7.31,-24.84,;8.08,-23.51,;7.31,-22.17,;1.02,-22.09,;1.49,-23.55,;.46,-24.69,;-1.08,-24.69,;-1.08,-26.23,;.46,-26.23,;-.45,-21.61,;-1.69,-22.51,)| Show InChI InChI=1S/C30H40N4O2/c1-31(2)27(35)24-13-15-26(16-14-24)33-22-29(34(28(33)36)21-23-9-8-10-23)17-19-30(20-18-29,32(3)4)25-11-6-5-7-12-25/h5-7,11-16,23H,8-10,17-22H2,1-4H3/t29-,30+ | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| 0.600 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Grünenthal GmbH
US Patent
| Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M... |
US Patent US10807988 (2020)
BindingDB Entry DOI: 10.7270/Q25Q5060 |
More data for this
Ligand-Target Pair | |
Nociceptin receptor
(Homo sapiens (Human)) | BDBM469357
(US10807988, Example SC_3008 | cis-2-[1-(Cyclobutyl...)Show SMILES CN(C)[C@]1(CC[C@]2(CN(C(=O)N2CC2CCC2)c2ccc(cc2C#N)S(C)(=O)=O)CC1)c1ccccc1 |r,wU:6.11,3.2,(6.57,-21.14,;5.03,-21.14,;4.26,-19.81,;4.26,-22.47,;3.49,-23.81,;1.95,-23.81,;1.18,-22.47,;.28,-21.23,;-1.19,-21.7,;-1.19,-23.24,;-2.43,-24.15,;.28,-23.72,;.75,-25.19,;-.28,-26.33,;-1.82,-26.33,;-1.82,-27.87,;-.28,-27.87,;-2.43,-20.8,;-3.84,-21.43,;-5.08,-20.52,;-4.92,-18.99,;-3.52,-18.36,;-2.27,-19.27,;-.86,-18.64,;.54,-18.02,;-6.17,-18.08,;-7.58,-18.71,;-6.94,-16.75,;-5.08,-17,;1.95,-21.14,;3.49,-21.14,;5.03,-23.81,;4.26,-25.14,;5.03,-26.48,;6.57,-26.48,;7.34,-25.14,;6.57,-23.81,)| Show InChI InChI=1S/C29H36N4O3S/c1-31(2)29(24-10-5-4-6-11-24)16-14-28(15-17-29)21-32(27(34)33(28)20-22-8-7-9-22)26-13-12-25(37(3,35)36)18-23(26)19-30/h4-6,10-13,18,22H,7-9,14-17,20-21H2,1-3H3/t28-,29+ | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| 0.600 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Grünenthal GmbH
US Patent
| Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M... |
US Patent US10807988 (2020)
BindingDB Entry DOI: 10.7270/Q25Q5060 |
More data for this
Ligand-Target Pair | |
Nociceptin receptor
(Homo sapiens (Human)) | BDBM239925
(US9403767, 104 | US9403767, 105)Show SMILES COc1ccc(cc1)C(=O)N(C)C1(CCC(CC1)(N(C)C)c1ccccc1)c1ccccc1 |(6.66,-13.19,;7.48,-11.88,;6.75,-10.52,;7.57,-9.22,;6.85,-7.86,;5.31,-7.8,;4.49,-9.11,;5.22,-10.47,;4.59,-6.44,;5.4,-5.14,;3.05,-6.39,;3.15,-7.93,;2.32,-5.03,;3.66,-4.26,;3.66,-2.72,;2.32,-1.95,;.99,-2.72,;.99,-4.26,;1.33,-.77,;-.18,-1.04,;1.86,.68,;3.31,-.77,;2.79,.68,;3.78,1.86,;5.29,1.59,;5.82,.14,;4.83,-1.04,;1.6,-6.39,;2.42,-7.7,;1.69,-9.06,;.15,-9.11,;-.66,-7.8,;.06,-6.44,)| Show InChI InChI=1S/C29H34N2O2/c1-30(2)28(24-11-7-5-8-12-24)19-21-29(22-20-28,25-13-9-6-10-14-25)31(3)27(32)23-15-17-26(33-4)18-16-23/h5-18H,19-22H2,1-4H3 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| 0.650 | n/a | n/a | n/a | n/a | n/a | n/a | 7.4 | n/a |
GRUENENTHAL GMBH
US Patent
| Assay Description
The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste... |
US Patent US9403767 (2016)
BindingDB Entry DOI: 10.7270/Q23R0RSJ |
More data for this
Ligand-Target Pair | |
Nociceptin receptor
(Homo sapiens (Human)) | BDBM469354
(US10807988, Example SC_3005 | cis-5-[1-(Cyclobutyl...)Show SMILES CN(C)[C@]1(CC[C@]2(CN(C(=O)N2CC2CCC2)c2cnc(nc2)C(N)=O)CC1)c1ccccc1 |r,wU:6.11,3.2,(6.39,21.95,;4.9,22.35,;4.5,23.83,;3.81,21.26,;3.04,19.92,;1.5,19.92,;.73,21.26,;-.17,22.5,;-1.64,22.03,;-1.64,20.49,;-2.88,19.58,;-.17,20.01,;.31,18.55,;-.73,17.4,;-2.27,17.4,;-2.27,15.86,;-.73,15.86,;-2.72,23.12,;-2.33,24.6,;-3.41,25.69,;-4.9,25.29,;-5.3,23.81,;-4.21,22.72,;-5.99,26.38,;-5.59,27.87,;-7.48,25.98,;1.5,22.59,;3.04,22.59,;4.9,20.17,;4.5,18.68,;5.59,17.59,;7.08,17.99,;7.48,19.48,;6.39,20.57,)| Show InChI InChI=1S/C26H34N6O2/c1-30(2)26(20-9-4-3-5-10-20)13-11-25(12-14-26)18-31(21-15-28-23(22(27)33)29-16-21)24(34)32(25)17-19-7-6-8-19/h3-5,9-10,15-16,19H,6-8,11-14,17-18H2,1-2H3,(H2,27,33)/t25-,26+ | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| 0.700 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Grünenthal GmbH
US Patent
| Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M... |
US Patent US10807988 (2020)
BindingDB Entry DOI: 10.7270/Q25Q5060 |
More data for this
Ligand-Target Pair | |
Mu-type opioid receptor
(Homo sapiens (Human)) | BDBM177936
(US9120797, 34)Show SMILES CN(C)C1(CCC2(CC1)NCCc1c2[nH]c2ccc(F)cc12)c1ccccc1 |(5.5,-.24,;4.01,.16,;3.61,1.65,;2.92,-.93,;2.15,-2.26,;.61,-2.26,;-.16,-.93,;.61,.4,;2.15,.4,;-.93,-2.26,;-2.47,-2.26,;-3.24,-.93,;-2.47,.4,;-.93,.4,;-.45,1.87,;-1.7,2.77,;-1.86,4.3,;-3.27,4.93,;-4.51,4.03,;-6,4.42,;-4.35,2.49,;-2.95,1.87,;3.69,-2.26,;2.92,-3.6,;3.69,-4.93,;5.23,-4.93,;6,-3.6,;5.23,-2.26,)| Show InChI InChI=1S/C24H28FN3/c1-28(2)24(17-6-4-3-5-7-17)13-11-23(12-14-24)22-19(10-15-26-23)20-16-18(25)8-9-21(20)27-22/h3-9,16,26-27H,10-15H2,1-2H3 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| 0.700 | -52.3 | n/a | n/a | n/a | n/a | n/a | n/a | 25 |
Gruenenthal GmbH
US Patent
| Assay Description
The receptor affinity for the human mu-opiate receptor was determined in a homogeneous batch in microtitre plates. For this, dilution series of the p... |
US Patent US9120797 (2015)
BindingDB Entry DOI: 10.7270/Q2X065T3 |
More data for this
Ligand-Target Pair | |
Nociceptin receptor
(Homo sapiens (Human)) | BDBM469419
(US10807988, Example SC_3063 | cis-5-[1-[(1-Cyano-c...)Show SMILES CN(C)[C@]1(CC[C@]2(CN(C(=O)N2CC2(CCC2)C#N)c2ccc(nc2)C#N)CC1)c1ccccc1 |r,wU:6.11,3.2,(4.15,11.34,;4.92,10,;6.46,10,;4.15,8.67,;3.38,7.34,;1.84,7.34,;1.07,8.67,;.17,9.92,;-1.3,9.44,;-1.3,7.9,;-2.54,6.99,;.17,7.42,;.64,5.96,;-.39,4.81,;-1.93,4.81,;-1.93,3.27,;-.39,3.27,;.95,4.04,;2.28,3.27,;-2.39,10.53,;-1.99,12.02,;-3.08,13.1,;-4.56,12.71,;-4.96,11.22,;-3.87,10.13,;-5.9,13.48,;-7.23,14.25,;1.84,10,;3.38,10,;4.92,7.34,;4.15,6,;4.92,4.67,;6.46,4.67,;7.23,6,;6.46,7.34,)| Show InChI InChI=1S/C28H32N6O/c1-32(2)28(22-7-4-3-5-8-22)15-13-27(14-16-28)21-33(24-10-9-23(17-29)31-18-24)25(35)34(27)20-26(19-30)11-6-12-26/h3-5,7-10,18H,6,11-16,20-21H2,1-2H3/t27-,28+ | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| 0.700 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Grünenthal GmbH
US Patent
| Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M... |
US Patent US10807988 (2020)
BindingDB Entry DOI: 10.7270/Q25Q5060 |
More data for this
Ligand-Target Pair | |
Mu-type opioid receptor
(Homo sapiens (Human)) | BDBM50100993
(CHEMBL3325881)Show SMILES Cl.CN(C)[C@]1(CC[C@@H](CC1)NC(=O)NCCCc1ccccc1)c1ccccc1 |r,wU:4.2,wD:7.9,(11.38,-21.45,;17.64,-17.11,;16.3,-16.34,;16.3,-14.8,;14.96,-17.12,;14.2,-18.45,;12.65,-18.46,;11.88,-17.13,;12.65,-15.79,;14.19,-15.79,;10.33,-17.13,;9.57,-18.46,;10.36,-19.8,;8.03,-18.48,;7.27,-19.82,;5.73,-19.82,;4.97,-21.15,;3.43,-21.17,;2.65,-19.84,;1.11,-19.85,;.35,-21.19,;1.14,-22.52,;2.67,-22.5,;15.76,-18.44,;15.02,-19.79,;15.81,-21.11,;17.36,-21.08,;18.1,-19.72,;17.3,-18.4,)| Show InChI InChI=1S/C24H33N3O/c1-27(2)24(21-13-7-4-8-14-21)17-15-22(16-18-24)26-23(28)25-19-9-12-20-10-5-3-6-11-20/h3-8,10-11,13-14,22H,9,12,15-19H2,1-2H3,(H2,25,26,28)/t22-,24- | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.700 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmacokinetics
Curated by ChEMBL
| Assay Description
Displacement of [3H]Naloxone from human mu opioid receptor receptor expressed in CHO-K1 cells after 90 mins |
ACS Med Chem Lett 5: 851-6 (2014)
Article DOI: 10.1021/ml500116x
BindingDB Entry DOI: 10.7270/Q28S4RPM |
More data for this
Ligand-Target Pair | |
Mu-type opioid receptor
(Homo sapiens (Human)) | BDBM50101095
(CHEMBL3325957)Show SMILES OC(=O)CC(O)(CC(O)=O)C(O)=O.CN(C)[C@]1(CC[C@@]2(CC1)OCCc1c2[nH]c2ccc(F)cc12)c1ccccc1 |r,wU:16.14,wD:19.21,(30.28,-8.84,;31.61,-9.6,;32.93,-8.84,;31.61,-11.13,;30.28,-11.9,;28.96,-11.13,;31.04,-13.22,;32.57,-13.22,;33.33,-14.55,;33.34,-11.9,;29.52,-13.21,;30.28,-14.54,;27.99,-13.21,;23.02,-15.74,;21.53,-16.15,;20.43,-15.06,;21.14,-17.65,;20.36,-18.98,;18.83,-18.97,;18.07,-17.64,;18.83,-16.31,;20.37,-16.32,;17.16,-18.9,;15.61,-18.74,;14.99,-17.32,;15.89,-16.07,;17.44,-16.24,;18.07,-14.82,;16.92,-13.78,;16.92,-12.23,;15.58,-11.46,;14.24,-12.24,;12.91,-11.46,;14.24,-13.78,;15.58,-14.55,;22.67,-17.66,;23.44,-19,;24.98,-19.01,;25.76,-17.68,;24.99,-16.33,;23.45,-16.33,)| | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.700 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmacokinetics
Curated by ChEMBL
| Assay Description
Displacement of [3H]naloxone from human MOP receptor expressed in CHO-K1 cells by scintillation proximity assay |
ACS Med Chem Lett 5: 857-62 (2014)
Article DOI: 10.1021/ml500117c
BindingDB Entry DOI: 10.7270/Q25140ZK |
More data for this
Ligand-Target Pair | |
Nociceptin receptor
(Homo sapiens (Human)) | BDBM239911
(US9403767, 76 | US9403767, 77)Show SMILES CN(CC1(C)CCC(CC1)(N(C)C)c1ccccc1)c1c[nH]c2ccccc12 |(2.68,2.55,;1.65,1.41,;.14,1.73,;-.33,3.19,;-1.28,1.98,;-1.51,4.18,;-1.24,5.7,;.2,6.23,;1.38,5.24,;1.11,3.72,;1.15,7.44,;2.68,7.22,;1.52,8.93,;-.27,7.69,;-1.78,8.01,;-2.26,9.48,;-1.23,10.62,;.28,10.3,;.76,8.83,;2.13,-.06,;1.22,-1.3,;2.13,-2.55,;3.59,-2.07,;4.92,-2.84,;6.26,-2.07,;6.26,-.53,;4.92,.24,;3.59,-.53,)| Show InChI InChI=1S/C25H33N3/c1-24(19-28(4)23-18-26-22-13-9-8-12-21(22)23)14-16-25(17-15-24,27(2)3)20-10-6-5-7-11-20/h5-13,18,26H,14-17,19H2,1-4H3 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| 0.710 | n/a | n/a | n/a | n/a | n/a | n/a | 7.4 | n/a |
GRUENENTHAL GMBH
US Patent
| Assay Description
The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste... |
US Patent US9403767 (2016)
BindingDB Entry DOI: 10.7270/Q23R0RSJ |
More data for this
Ligand-Target Pair | |
Mu-type opioid receptor
(Homo sapiens (Human)) | BDBM472098
(CIS-1-(Cyclobutyl-methyl)-8-dimethylamino-3-[(3-me...)Show SMILES CN(C)[C@]1(CC[C@]2(CN(Cc3cccc(c3)S(C)(=O)=O)C(=O)N2CC2CCC2)CC1)c1ccccc1 |r,wU:6.23,3.2,(16.32,28.25,;17.09,26.91,;18.63,26.91,;16.32,25.58,;15.55,24.25,;14.01,24.25,;13.24,25.58,;12.34,26.82,;10.87,26.35,;9.54,27.12,;8.2,26.35,;8.2,24.81,;6.87,24.04,;5.54,24.81,;5.54,26.35,;6.87,27.12,;4.2,27.12,;2.87,26.35,;2.87,27.89,;5.54,27.89,;10.87,24.81,;9.54,24.04,;12.34,24.33,;12.73,22.85,;11.65,21.76,;10.11,21.76,;10.11,20.22,;11.65,20.22,;14.01,26.91,;15.55,26.91,;17.09,24.25,;16.32,22.91,;17.09,21.58,;18.63,21.58,;19.4,22.91,;18.63,24.25,)| Show InChI InChI=1S/C29H39N3O3S/c1-30(2)29(25-12-5-4-6-13-25)17-15-28(16-18-29)22-31(27(33)32(28)21-23-9-7-10-23)20-24-11-8-14-26(19-24)36(3,34)35/h4-6,8,11-14,19,23H,7,9-10,15-18,20-22H2,1-3H3/t28-,29+ | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| 0.800 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GRUENENTHAL GMBH
US Patent
| Assay Description
Mu-Opioid Peptide (hMOP): The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buff... |
US Patent US10829480 (2020)
BindingDB Entry DOI: 10.7270/Q2SB48SB |
More data for this
Ligand-Target Pair | |
Nociceptin receptor
(Homo sapiens (Human)) | BDBM469822
(CIS-2-[1-(Cyclobutyl-methyl)-8-dimethylamino-2-oxo...)Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC(=O)Nc3ccc(cn3)S(C)(=O)=O)C(=O)N2CC2CCC2)CC1)c1ccccc1 |r,wU:6.26,3.2,(-2.76,30.22,;-4.25,30.62,;-4.65,32.11,;-5.34,29.53,;-6.11,28.2,;-7.65,28.2,;-8.42,29.53,;-9.32,30.78,;-10.79,30.3,;-11.88,31.39,;-13.36,30.99,;-13.76,29.5,;-14.45,32.08,;-15.94,31.68,;-16.34,30.2,;-17.83,29.8,;-18.92,30.89,;-18.52,32.37,;-17.03,32.77,;-20.4,30.49,;-20,29,;-21.89,30.09,;-20.8,31.97,;-10.79,28.76,;-12.12,27.99,;-9.32,28.29,;-8.92,26.8,;-10.01,25.71,;-11.55,25.71,;-11.55,24.17,;-10.01,24.17,;-7.65,30.87,;-6.11,30.87,;-4.25,28.44,;-4.65,26.96,;-3.56,25.87,;-2.07,26.27,;-1.67,27.75,;-2.76,28.84,)| Show InChI InChI=1S/C29H39N5O4S/c1-32(2)29(23-10-5-4-6-11-23)16-14-28(15-17-29)21-33(27(36)34(28)19-22-8-7-9-22)20-26(35)31-25-13-12-24(18-30-25)39(3,37)38/h4-6,10-13,18,22H,7-9,14-17,19-21H2,1-3H3,(H,30,31,35)/t28-,29+ | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| 0.800 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GRÜNENTHAL GMBH
US Patent
| Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl, 10 mM M... |
US Patent US10807989 (2020)
BindingDB Entry DOI: 10.7270/Q2222XTM |
More data for this
Ligand-Target Pair | |
Nociceptin receptor
(Homo sapiens (Human)) | BDBM469365
(US10807988, Example SC_3014 | cis-2-[1-(Cyclobutyl...)Show SMILES CN(C)[C@]1(CC[C@]2(CN(C(=O)N2CC2CCC2)c2ncc(cn2)C#N)CC1)c1ccccc1 |r,wU:6.11,3.2,(4.52,9.91,;5.29,8.58,;6.83,8.58,;4.52,7.24,;3.75,5.91,;2.21,5.91,;1.44,7.24,;.53,8.49,;-.93,8.01,;-.93,6.47,;-2.18,5.57,;.53,6,;1.01,4.53,;-.02,3.39,;-1.56,3.39,;-1.56,1.85,;-.02,1.85,;-2.26,8.78,;-2.26,10.32,;-3.6,11.09,;-4.93,10.32,;-4.93,8.78,;-3.6,8.01,;-6.27,11.09,;-7.6,11.86,;2.21,8.58,;3.75,8.58,;5.29,5.91,;4.52,4.58,;5.29,3.24,;6.83,3.24,;7.6,4.58,;6.83,5.91,)| Show InChI InChI=1S/C26H32N6O/c1-30(2)26(22-9-4-3-5-10-22)13-11-25(12-14-26)19-31(23-28-16-21(15-27)17-29-23)24(33)32(25)18-20-7-6-8-20/h3-5,9-10,16-17,20H,6-8,11-14,18-19H2,1-2H3/t25-,26+ | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| 0.800 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Grünenthal GmbH
US Patent
| Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M... |
US Patent US10807988 (2020)
BindingDB Entry DOI: 10.7270/Q25Q5060 |
More data for this
Ligand-Target Pair | |
Nociceptin receptor
(Homo sapiens (Human)) | BDBM469848
(CIS-6-[[2-[1-(Cyclobutyl-methyl)-8-dimethylamino-2...)Show SMILES CN(C)[C@]1(CC[C@]2(CN(CC(=O)Nc3cccc(n3)C(N)=O)C(=O)N2CC2CCC2)CC1)c1ccccc1 |r,wU:6.25,3.2,(20.47,-25.11,;18.98,-24.71,;18.58,-23.22,;17.89,-25.8,;17.12,-27.13,;15.58,-27.13,;14.81,-25.8,;13.9,-24.55,;12.44,-25.03,;11.11,-24.26,;9.77,-25.03,;9.77,-26.57,;8.44,-24.26,;7.1,-25.03,;7.1,-26.57,;5.77,-27.34,;4.44,-26.57,;4.44,-25.03,;5.77,-24.26,;3.1,-24.26,;1.77,-25.03,;3.1,-22.72,;12.44,-26.57,;11.11,-27.34,;13.9,-27.05,;14.3,-28.53,;13.21,-29.62,;11.67,-29.62,;11.67,-31.16,;13.21,-31.16,;15.58,-24.47,;17.12,-24.47,;19.22,-26.57,;19.22,-28.11,;20.56,-28.88,;21.89,-28.11,;21.89,-26.57,;20.56,-25.8,)| Show InChI InChI=1S/C29H38N6O3/c1-33(2)29(22-10-4-3-5-11-22)16-14-28(15-17-29)20-34(27(38)35(28)18-21-8-6-9-21)19-25(36)32-24-13-7-12-23(31-24)26(30)37/h3-5,7,10-13,21H,6,8-9,14-20H2,1-2H3,(H2,30,37)(H,31,32,36)/t28-,29+ | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| 0.800 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GRÜNENTHAL GMBH
US Patent
| Assay Description
The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl, 10 mM M... |
US Patent US10807989 (2020)
BindingDB Entry DOI: 10.7270/Q2222XTM |
More data for this
Ligand-Target Pair | |
Mu-type opioid receptor
(Homo sapiens (Human)) | BDBM472009
(CIS-1-(Cyclobutyl-methyl)-8-dimethylamino-8-phenyl...)Show SMILES CN(C)[C@]1(CC[C@]2(CN(Cc3cccnc3)C(=O)N2CC2CCC2)CC1)c1ccccc1 |r,wU:6.19,3.2,(-9.05,-2.42,;-8.28,-3.76,;-6.74,-3.76,;-9.05,-5.09,;-9.82,-6.42,;-11.36,-6.42,;-12.13,-5.09,;-13.04,-3.84,;-14.5,-4.32,;-15.84,-3.55,;-17.17,-4.32,;-17.17,-5.86,;-18.51,-6.63,;-19.84,-5.86,;-19.84,-4.32,;-18.51,-3.55,;-14.5,-5.86,;-15.84,-6.63,;-13.04,-6.34,;-12.27,-7.67,;-13.36,-8.76,;-14.9,-8.76,;-14.9,-10.3,;-13.36,-10.3,;-11.36,-3.76,;-9.82,-3.76,;-8.28,-6.42,;-9.05,-7.76,;-8.28,-9.09,;-6.74,-9.09,;-5.97,-7.76,;-6.74,-6.42,)| Show InChI InChI=1S/C27H36N4O/c1-29(2)27(24-11-4-3-5-12-24)15-13-26(14-16-27)21-30(19-23-10-7-17-28-18-23)25(32)31(26)20-22-8-6-9-22/h3-5,7,10-12,17-18,22H,6,8-9,13-16,19-21H2,1-2H3/t26-,27+ | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| 0.800 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GRUENENTHAL GMBH
US Patent
| Assay Description
Mu-Opioid Peptide (hMOP): The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buff... |
US Patent US10829480 (2020)
BindingDB Entry DOI: 10.7270/Q2SB48SB |
More data for this
Ligand-Target Pair | |
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