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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Nociceptin receptor | ||
| Ligand | BDBM469352 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Human Nociceptin/Orphanin FQ Peptide (hNOP) Receptor Binding Assay | ||
| Ki | 0.400±n/a nM | ||
| Citation |  Kuehnert, S; Koenigs, R; Kless, A; Wegert, A; Konetzki, I; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W 3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent US10807988 Publication Date 10/20/2020 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Nociceptin receptor | |||
| Name: | Nociceptin receptor | ||
| Synonyms: | KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146 | ||
| Type: | G Protein-Coupled Receptor (GPCR) | ||
| Mol. Mass.: | 40702.87 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P41146 | ||
| Residue: | 370 | ||
| Sequence: |
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| BDBM469352 | |||
| n/a | |||
| Name | BDBM469352 | ||
| Synonyms: | US10807988, Example SC_3003 | cis-5-[1-(Cyclobutyl-methyl)-8-dimethylamino-2-oxo-8-phenyl-1,3- diazaspiro[4.5]decan-3-yl]-4-methoxy-pyrimidine-2-carbonitrile | ||
| Type | Small organic molecule | ||
| Emp. Form. | C27H34N6O2 | ||
| Mol. Mass. | 474.5979 | ||
| SMILES | COc1nc(ncc1N1C[C@]2(CC[C@@](CC2)(N(C)C)c2ccccc2)N(CC2CCC2)C1=O)C#N |r,wU:10.27,13.17,(-.93,-.89,;-.93,-2.43,;-2.26,-3.2,;-3.6,-2.43,;-4.93,-3.2,;-4.93,-4.74,;-3.6,-5.51,;-2.26,-4.74,;-.93,-5.51,;.53,-5.03,;1.44,-6.28,;2.21,-7.61,;3.75,-7.61,;4.52,-6.28,;3.75,-4.94,;2.21,-4.94,;5.29,-4.94,;6.83,-4.94,;4.52,-3.61,;5.29,-7.61,;4.52,-8.95,;5.29,-10.28,;6.83,-10.28,;7.6,-8.95,;6.83,-7.61,;.53,-7.52,;1.01,-8.99,;-.02,-10.13,;-1.56,-10.13,;-1.56,-11.67,;-.02,-11.67,;-.93,-7.05,;-2.18,-7.95,;-6.27,-2.43,;-7.6,-1.66,)| | ||
| Structure | 
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