| Reaction Details |
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 | Report a problem with these data |
| Target | Isoform Bcl-X(L) of Bcl-2-like protein 1 (Bcl-xL) |
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| Ligand | BDBM473868 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | fluorescence polarization competition assay (FPCA) |
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| Ki | 1672±351 nM |
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| Citation |  Fletcher, S; Lanning, M; Chen, L Small molecule inhibitors of the MCL-1 oncoprotein and uses thereof US Patent US10858316 Publication Date 12/8/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| Isoform Bcl-X(L) of Bcl-2-like protein 1 (Bcl-xL) |
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| Name: | Isoform Bcl-X(L) of Bcl-2-like protein 1 (Bcl-xL) |
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| Synonyms: | B-cell lymphoma-extra large protein (Bcl-xL) | B2CL1_HUMAN | BCL-xL | BCL2L | BCL2L1 | BCLX | Bcl-2-like protein 1 (Bcl-xL) | Isoform Bcl-X(L) |
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| Type: | Homodimers/heterodimers with BAX, BAK and BCL2 |
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| Mol. Mass.: | 26053.63 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_510901 |
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| Residue: | 233 |
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| Sequence: | MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLA
DSPAVNGATAHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAY
QSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEP
WIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
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| BDBM473868 |
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| n/a |
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| Name | BDBM473868 |
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| Synonyms: | 4-(N-benzyl-4-(4- chloro-3,5- dimethylphenoxy) phenyl- sulfonamido)-2- hydroxybenzoic acid | US10858316, Compound LC-4-118 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H24ClNO6S |
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| Mol. Mass. | 538.011 |
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| SMILES | Cc1cc(Oc2ccc(cc2)S(=O)(=O)N(Cc2ccccc2)c2ccc(C(O)=O)c(O)c2)cc(C)c1Cl |
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| Structure | 
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