Reaction Details |
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Target | Isoform PDE9A2 of High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2) |
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Ligand | BDBM484509 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Fluorescence Polarization Assay |
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Ki | 2.20±n/a nM |
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Citation | Arasappan, A; Cox, JM; Debenham, JS; Guo, Z; He, J; Hussain, Z; Lai, Z; Li, D; Meng, D; Raghavan, S; Tyagarajan, S Substituted pyrazolo[3,4-d]pyrimidines as PDE9 inhibitors US Patent US10934294 Publication Date 3/2/2021 |
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More Info.: | Get all data from this article, Assay Method |
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Isoform PDE9A2 of High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2) |
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Name: | Isoform PDE9A2 of High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2) |
Synonyms: | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2) | PDE9A | PDE9A_HUMAN | Phosphodiesterase 9A (PDE9A2) | Phosphodiesterase 9A2 |
Type: | Protein |
Mol. Mass.: | 61702.98 |
Organism: | Homo sapiens (Human) |
Description: | O76083-2 |
Residue: | 533 |
Sequence: | MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAM
VSIDPTMPANSERTPYKVRPVAIKQLSEREELIQSVLAQVAEQFSRAFKINELKAEVANH
LAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDV
PTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLF
CVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYN
NTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLI
LATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCL
LEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIML
QPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA
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BDBM484509 |
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n/a |
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Name | BDBM484509 |
Synonyms: | US10934294, Example 31 | US10934294, Example 32 | US10934294, Example 33 | US11028092, Example 33 |
Type | Small organic molecule |
Emp. Form. | C23H19F3N8O |
Mol. Mass. | 480.4452 |
SMILES | CC(c1ccc(nc1)C(F)(F)F)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncc(C)cn1 |
Structure |
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