Ki Summary

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Target

Isoform PDE9A2 of High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)

Ligand

BDBM484541

Substrate/Competitor

n/a

Meas. Tech.

Fluorescence Polarization Assay

0.010±n/a nM

Citation

Arasappan, A; Cox, JM; Debenham, JS; Guo, Z; He, J; Hussain, Z; Lai, Z; Li, D; Meng, D; Raghavan, S; Tyagarajan, S Substituted pyrazolo[3,4-d]pyrimidines as PDE9 inhibitors US Patent US10934294 Publication Date 3/2/2021

More Info.:

Get all data from this article, Assay Method

Isoform PDE9A2 of High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)

Name:

Isoform PDE9A2 of High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)

Synonyms:

High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2) | PDE9A | PDE9A_HUMAN | Phosphodiesterase 9A (PDE9A2) | Phosphodiesterase 9A2

Type:

Protein

Mol. Mass.:

61702.98

Organism:

Homo sapiens (Human)

Description:

O76083-2

Residue:

533

Sequence:

MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAM
VSIDPTMPANSERTPYKVRPVAIKQLSEREELIQSVLAQVAEQFSRAFKINELKAEVANH
LAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDV
PTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLF
CVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYN
NTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLI
LATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCL
LEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIML
QPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA

BDBM484541

n/a

Name

BDBM484541

Synonyms:

US10934294, Example 62 | US11028092, Example 63

Type

Small organic molecule

Emp. Form.

C24H21F3N8O

Mol. Mass.

494.4717

SMILES

CCc1cnc(nc1)C1CCC1c1nc2n(nc(C#N)c2c(=O)[nH]1)[C@@H](C)c1ccc(nc1)C(F)(F)F |r|

Structure