| Reaction Details |
|---|
 | Report a problem with these data |
| Target | SH2B adapter protein 2 |
|---|
| Ligand | BDBM484975 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Allosteric Inhibition Assay |
|---|
| IC50 | <50±n/a nM |
|---|
| Citation |  Taylor, AM; Lescarbeau, A; Kelley, EH; Shortsleeves, KC; Walters, WP; Murcko, MA; Giordanetto, F; Therrien, E SHP2 phosphatase inhibitors and methods of use thereof US Patent US10934302 Publication Date 3/2/2021 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| SH2B adapter protein 2 |
|---|
| Name: | SH2B adapter protein 2 |
|---|
| Synonyms: | APS | Adapter protein with pleckstrin homology and Src homology 2 domains | SH2 and PH domain-containing adapter protein APS | SH2B2 | SH2B2_HUMAN |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 67733.52 |
|---|
| Organism: | Human |
|---|
| Description: | O14492 |
|---|
| Residue: | 632 |
|---|
| Sequence: | MNGAGPGPAAAAPVPVPVPVPDWRQFCELHAQAAAVDFAHKFCRFLRDNPAYDTPDAGAS
FSRHFAANFLDVFGEEVRRVLVAGPTTRGAAVSAEAMEPELADTSALKAAPYGHSRSSED
VSTHAATKARVRKGFSLRNMSLCVVDGVRDMWHRRASPEPDAAAAPRTAEPRDKWTRRLR
LSRTLAAKVELVDIQREGALRFMVADDAAAGSGGSAQWQKCRLLLRRAVAEERFRLEFFV
PPKASRPKVSIPLSAIIEVRTTMPLEMPEKDNTFVLKVENGAEYILETIDSLQKHSWVAD
IQGCVDPGDSEEDTELSCTRGGCLASRVASCSCELLTDAVDLPRPPETTAVGAVVTAPHS
RGRDAVRESLIHVPLETFLQTLESPGGSGSDSNNTGEQGAETDPEAEPELELSDYPWFHG
TLSRVKAAQLVLAGGPRNHGLFVIRQSETRPGEYVLTFNFQGKAKHLRLSLNGHGQCHVQ
HLWFQSVLDMLRHFHTHPIPLESGGSADITLRSYVRAQDPPPEPGPTPPAAPASPACWSD
SPGQHYFSSLAAAACPPASPSDAAGASSSSASSSSAASGPAPPRPVEGQLSARSRSNSAE
RLLEAVAATAAEEPPEAAPGRARAVENQYSFY
|
|
|
|---|
| BDBM484975 |
|---|
| n/a |
|---|
| Name | BDBM484975 |
|---|
| Synonyms: | US10934302, Example 226 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C28H28N8O |
|---|
| Mol. Mass. | 492.5749 |
|---|
| SMILES | N[C@@H]1c2ccccc2O[C@@]11C[C@@H]2CC3(C[C@H](C1)N23)c1cnc2c(n[nH]c2n1)N1CCCc2ncccc12 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
