| Reaction Details |
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 | Report a problem with these data |
| Target | SH2B adapter protein 2 |
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| Ligand | BDBM484999 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Allosteric Inhibition Assay |
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| IC50 | <50±n/a nM |
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| Citation |  Taylor, AM; Lescarbeau, A; Kelley, EH; Shortsleeves, KC; Walters, WP; Murcko, MA; Giordanetto, F; Therrien, E SHP2 phosphatase inhibitors and methods of use thereof US Patent US10934302 Publication Date 3/2/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| SH2B adapter protein 2 |
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| Name: | SH2B adapter protein 2 |
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| Synonyms: | APS | Adapter protein with pleckstrin homology and Src homology 2 domains | SH2 and PH domain-containing adapter protein APS | SH2B2 | SH2B2_HUMAN |
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| Type: | Protein |
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| Mol. Mass.: | 67733.52 |
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| Organism: | Human |
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| Description: | O14492 |
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| Residue: | 632 |
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| Sequence: | MNGAGPGPAAAAPVPVPVPVPDWRQFCELHAQAAAVDFAHKFCRFLRDNPAYDTPDAGAS
FSRHFAANFLDVFGEEVRRVLVAGPTTRGAAVSAEAMEPELADTSALKAAPYGHSRSSED
VSTHAATKARVRKGFSLRNMSLCVVDGVRDMWHRRASPEPDAAAAPRTAEPRDKWTRRLR
LSRTLAAKVELVDIQREGALRFMVADDAAAGSGGSAQWQKCRLLLRRAVAEERFRLEFFV
PPKASRPKVSIPLSAIIEVRTTMPLEMPEKDNTFVLKVENGAEYILETIDSLQKHSWVAD
IQGCVDPGDSEEDTELSCTRGGCLASRVASCSCELLTDAVDLPRPPETTAVGAVVTAPHS
RGRDAVRESLIHVPLETFLQTLESPGGSGSDSNNTGEQGAETDPEAEPELELSDYPWFHG
TLSRVKAAQLVLAGGPRNHGLFVIRQSETRPGEYVLTFNFQGKAKHLRLSLNGHGQCHVQ
HLWFQSVLDMLRHFHTHPIPLESGGSADITLRSYVRAQDPPPEPGPTPPAAPASPACWSD
SPGQHYFSSLAAAACPPASPSDAAGASSSSASSSSAASGPAPPRPVEGQLSARSRSNSAE
RLLEAVAATAAEEPPEAAPGRARAVENQYSFY
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| BDBM484999 |
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| n/a |
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| Name | BDBM484999 |
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| Synonyms: | Syntheses of (3S)-1′-[5-(cyclopentylsulfanyl)-3-methylpyrazin-2-yl]-1,3-dihydrospiro[indene-2,4′-piperidin]-3-amine and (3S)-1′-[5-(cyclopentylsulfanyl)-6-methylpyrazin-2-yl]-1,3-dihydrospiro[indene-2,4′-piperidin]-3-amine | US10934302, Example 250 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H30N4S |
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| Mol. Mass. | 394.576 |
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| SMILES | Cc1nc(cnc1SC1CCCC1)N1CCC2(Cc3ccccc3[C@H]2N)CC1 |r| |
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| Structure | 
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