| Reaction Details |
|---|
 | Report a problem with these data |
| Target | SH2B adapter protein 2 |
|---|
| Ligand | BDBM485007 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Allosteric Inhibition Assay |
|---|
| IC50 | <50±n/a nM |
|---|
| Citation |  Taylor, AM; Lescarbeau, A; Kelley, EH; Shortsleeves, KC; Walters, WP; Murcko, MA; Giordanetto, F; Therrien, E SHP2 phosphatase inhibitors and methods of use thereof US Patent US10934302 Publication Date 3/2/2021 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| SH2B adapter protein 2 |
|---|
| Name: | SH2B adapter protein 2 |
|---|
| Synonyms: | APS | Adapter protein with pleckstrin homology and Src homology 2 domains | SH2 and PH domain-containing adapter protein APS | SH2B2 | SH2B2_HUMAN |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 67733.52 |
|---|
| Organism: | Human |
|---|
| Description: | O14492 |
|---|
| Residue: | 632 |
|---|
| Sequence: | MNGAGPGPAAAAPVPVPVPVPDWRQFCELHAQAAAVDFAHKFCRFLRDNPAYDTPDAGAS
FSRHFAANFLDVFGEEVRRVLVAGPTTRGAAVSAEAMEPELADTSALKAAPYGHSRSSED
VSTHAATKARVRKGFSLRNMSLCVVDGVRDMWHRRASPEPDAAAAPRTAEPRDKWTRRLR
LSRTLAAKVELVDIQREGALRFMVADDAAAGSGGSAQWQKCRLLLRRAVAEERFRLEFFV
PPKASRPKVSIPLSAIIEVRTTMPLEMPEKDNTFVLKVENGAEYILETIDSLQKHSWVAD
IQGCVDPGDSEEDTELSCTRGGCLASRVASCSCELLTDAVDLPRPPETTAVGAVVTAPHS
RGRDAVRESLIHVPLETFLQTLESPGGSGSDSNNTGEQGAETDPEAEPELELSDYPWFHG
TLSRVKAAQLVLAGGPRNHGLFVIRQSETRPGEYVLTFNFQGKAKHLRLSLNGHGQCHVQ
HLWFQSVLDMLRHFHTHPIPLESGGSADITLRSYVRAQDPPPEPGPTPPAAPASPACWSD
SPGQHYFSSLAAAACPPASPSDAAGASSSSASSSSAASGPAPPRPVEGQLSARSRSNSAE
RLLEAVAATAAEEPPEAAPGRARAVENQYSFY
|
|
|
|---|
| BDBM485007 |
|---|
| n/a |
|---|
| Name | BDBM485007 |
|---|
| Synonyms: | US10934302, Example 258 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H26ClN5OS |
|---|
| Mol. Mass. | 468.014 |
|---|
| SMILES | N[C@@H]1c2ccccc2CC11CCN(CC1)c1ccc(Sc2ccnc(N)c2Cl)nc1CO |r| |
|---|
| Structure | 
|
|---|
Search and Browse
