Reaction Details | |||
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Target | Activin receptor type-1 [172-499] | ||
Ligand | BDBM451777 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ADPGlo Assay | ||
IC50 | 11.0±n/a nM | ||
Citation | Arista, L; Babu, S; Bian, J; Cui, K; Dillon, MP; Lattmann, R; Li, J; Liao, L; Lizos, D; Ramos, R; Stiefl, NJ; Ullrich, T; Usselmann, P; Wang, X; Waykole, LM; Weiler, S; Zhang, Y; Zhou, Y; Zhu, T Aminopyridine derivatives and their use as selective ALK-2 inhibitors US Patent US10947218 Publication Date 3/16/2021 | ||
More Info.: | Get all data from this article, Assay Method | ||
Activin receptor type-1 [172-499] | |||
Name: | Activin receptor type-1 [172-499] | ||
Synonyms: | ACVR1 | ACVR1_HUMAN | ACVRLK2 | Activin receptor type-1 (ACVR1) | Activin receptor-like kinase 2 (ALK-2)(aa 172-499) | Activin receptor-like kinase 2 (ALK2)(172-499) | ||
Type: | Enzyme Catalytic Domain | ||
Mol. Mass.: | 37139.64 | ||
Organism: | Homo sapiens (Human) | ||
Description: | aa 172-499 | ||
Residue: | 328 | ||
Sequence: |
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BDBM451777 | |||
n/a | |||
Name | BDBM451777 | ||
Synonyms: | US10710980, Example 9 | US10947218, Example 9 | ||
Type | Small organic molecule | ||
Emp. Form. | C26H34N4O2 | ||
Mol. Mass. | 434.5738 | ||
SMILES | CC(C)N1C[C@@H]2C[C@@]2(C1)c1ccc(cc1)-c1cnc(N)c(c1)C(=O)N[C@H]1CC[C@H](O)CC1 |r,wU:5.5,25.28,wD:7.10,28.32,(6.81,-4.95,;7.72,-3.7,;9.25,-3.86,;7.09,-2.29,;7.86,-.96,;6.83,.18,;5.58,1.09,;5.42,-.44,;5.58,-1.97,;4.09,.33,;2.76,-.44,;1.42,.33,;1.42,1.87,;2.76,2.64,;4.09,1.87,;.09,2.64,;.09,4.18,;-1.25,4.95,;-2.58,4.18,;-3.91,4.95,;-2.58,2.64,;-1.25,1.87,;-3.91,1.87,;-5.25,2.64,;-3.91,.33,;-5.25,-.44,;-5.25,-1.98,;-6.58,-2.75,;-7.91,-1.98,;-9.25,-2.75,;-7.91,-.44,;-6.58,.33,)| | ||
Structure |