Reaction Details | |||
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Target | Activin receptor type-1 [172-499] | ||
Ligand | BDBM451791 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ADPGlo Assay | ||
IC50 | 9.00±n/a nM | ||
Citation | Arista, L; Babu, S; Bian, J; Cui, K; Dillon, MP; Lattmann, R; Li, J; Liao, L; Lizos, D; Ramos, R; Stiefl, NJ; Ullrich, T; Usselmann, P; Wang, X; Waykole, LM; Weiler, S; Zhang, Y; Zhou, Y; Zhu, T Aminopyridine derivatives and their use as selective ALK-2 inhibitors US Patent US10947218 Publication Date 3/16/2021 | ||
More Info.: | Get all data from this article, Assay Method | ||
Activin receptor type-1 [172-499] | |||
Name: | Activin receptor type-1 [172-499] | ||
Synonyms: | ACVR1 | ACVR1_HUMAN | ACVRLK2 | Activin receptor type-1 (ACVR1) | Activin receptor-like kinase 2 (ALK-2)(aa 172-499) | Activin receptor-like kinase 2 (ALK2)(172-499) | ||
Type: | Enzyme Catalytic Domain | ||
Mol. Mass.: | 37139.64 | ||
Organism: | Homo sapiens (Human) | ||
Description: | aa 172-499 | ||
Residue: | 328 | ||
Sequence: |
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BDBM451791 | |||
n/a | |||
Name | BDBM451791 | ||
Synonyms: | US10710980, Example 23 | US10947218, Example 23 | ||
Type | Small organic molecule | ||
Emp. Form. | C25H32N4O2 | ||
Mol. Mass. | 420.5472 | ||
SMILES | Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(CN2CC3(CCC3)C2)cc1 |r,wU:10.10,wD:13.14,(-4.25,3.17,;-2.92,2.4,;-1.59,3.17,;-.25,2.4,;-.25,.86,;-1.59,.09,;-2.92,.86,;-4.25,.09,;-4.25,-1.45,;-5.59,.86,;-6.92,.09,;-6.52,-1.39,;-7.61,-2.48,;-9.1,-2.08,;-10.19,-3.17,;-9.5,-.6,;-8.41,.49,;1.08,.09,;1.08,-1.45,;2.41,-2.22,;3.75,-1.45,;5.08,-2.22,;6.42,-1.45,;7.9,-1.85,;8.3,-.36,;9.79,-.76,;10.19,.73,;8.7,1.13,;6.81,.04,;3.75,.09,;2.41,.86,)| | ||
Structure |