Ki Summary

Reaction Details

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Target

Activin receptor type-1 [172-499,R206H]

Ligand

BDBM451772

Substrate/Competitor

n/a

Meas. Tech.

Caliper Assay

IC50

7.00±n/a nM

Citation

Arista, L; Babu, S; Bian, J; Cui, K; Dillon, MP; Lattmann, R; Li, J; Liao, L; Lizos, D; Ramos, R; Stiefl, NJ; Ullrich, T; Usselmann, P; Wang, X; Waykole, LM; Weiler, S; Zhang, Y; Zhou, Y; Zhu, T Aminopyridine derivatives and their use as selective ALK-2 inhibitors US Patent US10947218 Publication Date 3/16/2021

More Info.:

Get all data from this article, Assay Method

Activin receptor type-1 [172-499,R206H]

Name:

Activin receptor type-1 [172-499,R206H]

Synonyms:

ACVR1 | ACVR1_HUMAN | ACVRLK2 | Activin receptor type-1 (ALK2 FOP) (R206H aa 172-499) | Activin receptor type-1 (ALK2)(FOP)(R206H)

Type:

Enzyme Catalytic Domain

Mol. Mass.:

37120.09

Organism:

Homo sapiens (Human)

Description:

aa 172-499

Residue:

328

Sequence:

TTNVGDSTLADLLDHSCTSGSGSGLPFLVQRTVAHQITLLECVGKGRYGEVWRGSWQGEN
VAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSL
YDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCC
IADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVL
WEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLA
KLMKECWYQNPSARLTALRIKKTLTKID

BDBM451772

n/a

Name

BDBM451772

Synonyms:

US10710980, Example 4 | US10947218, Example 4

Type

Small organic molecule

Emp. Form.

C25H32N4O3

Mol. Mass.

436.5466

SMILES

C[C@H](N1CC2(COC2)C1)c1ccc(cc1)-c1cnc(N)c(c1)C(=O)N[C@H]1CC[C@H](O)CC1 |r,wU:1.0,25.28,wD:28.32,(5.54,-3.46,;5.54,-1.92,;6.88,-1.16,;8.36,-1.55,;8.76,-.07,;10.25,-.46,;10.65,1.02,;9.16,1.42,;7.27,.33,;4.21,-1.16,;2.87,-1.92,;1.54,-1.16,;1.54,.38,;2.87,1.16,;4.21,.38,;.21,1.16,;.21,2.7,;-1.13,3.46,;-2.46,2.7,;-3.79,3.46,;-2.46,1.16,;-1.13,.38,;-3.79,.38,;-3.79,-1.16,;-5.13,1.16,;-6.46,.38,;-6.6,-1.15,;-7.99,-1.8,;-9.25,-.92,;-10.65,-1.57,;-9.12,.62,;-7.72,1.27,)|

Structure