Ki Summary

Reaction Details

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Target

Activin receptor type-1 [172-499]

Ligand

BDBM451776

Substrate/Competitor

n/a

Meas. Tech.

Caliper Assay

IC50

12.0±n/a nM

Citation

Arista, L; Babu, S; Bian, J; Cui, K; Dillon, MP; Lattmann, R; Li, J; Liao, L; Lizos, D; Ramos, R; Stiefl, NJ; Ullrich, T; Usselmann, P; Wang, X; Waykole, LM; Weiler, S; Zhang, Y; Zhou, Y; Zhu, T Aminopyridine derivatives and their use as selective ALK-2 inhibitors US Patent US10947218 Publication Date 3/16/2021

More Info.:

Get all data from this article, Assay Method

Activin receptor type-1 [172-499]

Name:

Activin receptor type-1 [172-499]

Synonyms:

Type:

Enzyme Catalytic Domain

Mol. Mass.:

37139.64

Organism:

Homo sapiens (Human)

Description:

aa 172-499

Residue:

328

Sequence:

TTNVGDSTLADLLDHSCTSGSGSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGEN
VAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSL
YDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCC
IADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVL
WEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLA
KLMKECWYQNPSARLTALRIKKTLTKID

BDBM451776

n/a

Name

BDBM451776

Synonyms:

US10710980, Example 8 | US10947218, Example 8

Type

Small organic molecule

Emp. Form.

C25H34FN5O2

Mol. Mass.

455.5682

SMILES

CC(C)N1CCN(CC1)c1ccc(c(F)c1)-c1cnc(N)c(c1)C(=O)N[C@H]1CC[C@H](O)CC1 |r,wU:26.28,wD:29.32,(10.76,-2.31,;9.43,-3.08,;9.43,-4.62,;8.09,-2.31,;6.76,-3.08,;5.43,-2.31,;5.43,-.77,;6.76,,;8.09,-.77,;4.09,,;2.76,-.77,;1.43,,;1.43,1.54,;2.76,2.31,;2.76,3.83,;4.09,1.54,;.09,2.31,;.09,3.85,;-1.24,4.62,;-2.57,3.85,;-3.91,4.62,;-2.57,2.31,;-1.24,1.54,;-3.91,1.54,;-3.91,,;-5.24,2.31,;-6.58,1.54,;-6.71,.01,;-8.11,-.64,;-9.37,.24,;-10.76,-.41,;-9.23,1.77,;-7.84,2.42,)|

Structure