Reaction Details |
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Target | Diacylglycerol O-acyltransferase 2 |
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Ligand | BDBM486407 |
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Substrate/Competitor | n/a |
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Meas. Tech. | DGAT2 Enzymatic Activity Assay |
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IC50 | 15.0±n/a nM |
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Citation | Shen, D; Graham, TH; Jiang, J; Ding, F; Tudge, C Indole derivatives useful as inhibitors of diacylglyceride O-acyltransferase 2 US Patent US10947222 Publication Date 3/16/2021 |
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More Info.: | Get all data from this article, Assay Method |
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Diacylglycerol O-acyltransferase 2 |
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Name: | Diacylglycerol O-acyltransferase 2 |
Synonyms: | ARAT | Acyl-CoA retinol O-fatty-acyltransferase | DGAT2 | DGAT2_HUMAN | Diacylglycerol O-acyltransferase 2 (DGAT2) | Diglyceride acyltransferase 2 | Retinol O-fatty-acyltransferase |
Type: | Multi-pass membrane protein |
Mol. Mass.: | 43848.90 |
Organism: | Homo sapiens (Human) |
Description: | Q96PD7 |
Residue: | 388 |
Sequence: | MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLN
RSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKG
GRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATE
VSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGG
AAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQ
KKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHT
MYMEALVKLFDKHKTKFGLPETEVLEVN
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BDBM486407 |
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n/a |
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Name | BDBM486407 |
Synonyms: | N-(1,1-dioxidotetrahydrothiophen- 3-yl)-1-(4-fluorophenyl)-3-[3-(1H- pyrazol-1-yl)phenyl]-1H-indole-6- carboxamide (racemic) | US10947222, Example 38 |
Type | Small organic molecule |
Emp. Form. | C28H23FN4O3S |
Mol. Mass. | 514.571 |
SMILES | Fc1ccc(cc1)-n1cc(-c2cccc(c2)-n2cccn2)c2ccc(cc12)C(=O)NC1CCS(=O)(=O)C1 |
Structure |
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