Reaction Details |
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Target | Stimulator of interferon genes protein [H232R] |
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Ligand | BDBM490797 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Surface Plasmon Resonance (SPR) Binding |
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Kd | 29.0±n/a nM |
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Citation | Wythes, MJ; McAlpine, IJ; Patman, R; Rui, EY; Maderna, A; Jalaie, M; Gajiwala, KS Cyclopentane-based modulators of STING (stimulator of interferon genes) US Patent US10968242 Publication Date 4/6/2021 |
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More Info.: | Get all data from this article, Assay Method |
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Stimulator of interferon genes protein [H232R] |
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Name: | Stimulator of interferon genes protein [H232R] |
Synonyms: | ERIS | MITA | STING | STING1 | STING_HUMAN | Stimulator of interferon genes protein STING (H232R) | TMEM173 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 42215.19 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 379 |
Sequence: | MPHSSLHPSIPCPRGHGAQKAALVLLSACLVTLWGLGEPPEHTLRYLVLHLASLQLGLLL
NGVCSLAEELRHIHSRYRGSYWRTVRACLGCPLRRGALLLLSIYFYYSLPNAVGPPFTWM
LALLGLSQALNILLGLKGLAPAEISAVCEKGNFNVAHGLAWSYYIGYLRLILPELQARIR
TYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQTGDRAGIKDRVY
SNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILA
DAPESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEEKEEVTVGSLKTSAVPSTSTMSQE
PELLISGMEKPLPLRTDFS
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BDBM490797 |
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n/a |
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Name | BDBM490797 |
Synonyms: | US10968242, Example 20 Peak 2 |
Type | Small organic molecule |
Emp. Form. | C22H25FN8O11P2S |
Mol. Mass. | 690.492 |
SMILES | Cn1cnc2n(cnc2c1=O)[C@@H]1C[C@@H]2OP(O)(=O)O[C@@H]3[C@@H](COP(S)(=O)O[C@@H]1[C@H]2O)O[C@H]([C@@H]3F)n1cnc2c1ncn(C)c2=O |r| |
Structure |
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