| Reaction Details |
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 | Report a problem with these data |
| Target | 5'-AMP-activated protein kinase catalytic subunit alpha-2 |
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| Ligand | BDBM50248937 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Selectivity Screening (AMPK) |
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| Ki | 9.20±n/a nM |
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| Citation |  Dalby, KN; Edupuganti, R; Taliaferro, J; Lee, JH Indolinone derivatives as inhibitors of maternal embryonic leucine zipper kinase US Patent US10981896 Publication Date 4/20/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| 5'-AMP-activated protein kinase catalytic subunit alpha-2 |
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| Name: | 5'-AMP-activated protein kinase catalytic subunit alpha-2 |
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| Synonyms: | AAPK2_HUMAN | ACACA kinase | AMP-activated protein kinase, alpha-2 subunit | AMPK | AMPK subunit alpha-2 | AMPK-alpha2 | AMPK2 | Acetyl-CoA carboxylase kinase | Hydroxymethylglutaryl-CoA reductase kinase | PRKAA2 |
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| Type: | Enzyme |
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| Mol. Mass.: | 62331.02 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P54646 |
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| Residue: | 552 |
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| Sequence: | MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGK
IKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLF
QQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYA
APEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRS
VATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKF
ECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIP
PGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVY
RAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQR
SGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFF
EMCASLITTLAR
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| BDBM50248937 |
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| n/a |
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| Name | BDBM50248937 |
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| Synonyms: | CHEMBL4062168 | US10981896, Compound 15 |
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| Type | Small organic molecule |
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| Emp. Form. | C31H33N5O4 |
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| Mol. Mass. | 539.6248 |
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| SMILES | COC(=O)c1ccc2NC(=O)\C(=C(/Nc3ccc(cc3)N(C)C(=O)CN3CCN(C)CC3)c3ccccc3)c2c1 |
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| Structure | 
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