Reaction Details |
| Report a problem with these data |
Target | Ketohexokinase |
---|
Ligand | BDBM319582 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | Biological Assay |
---|
IC50 | 1.50±n/a nM |
---|
Citation | Dowling, M; Fernando, D; Futatsugi, K; Huard, K; Magee, TV; Raymer, B; Shavnya, A; Smith, A; Thuma, B; Tsai, A; Tu, M Substituted 3-azabicyclo[3.1.0]hexanes as ketohexokinase inhibitors US Patent US10988463 Publication Date 4/27/2021 |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Ketohexokinase |
---|
Name: | Ketohexokinase |
Synonyms: | Hepatic fructokinase | KHK | KHK_HUMAN | Ketohexokinase | Ketohexokinase (KHK) | Ketohexokinase (KHK) Isoform C |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 32521.64 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 298 |
Sequence: | MEEKQILCVGLVVLDVISLVDKYPKEDSEIRCLSQRWQRGGNASNSCTVLSLLGAPCAFM
GSMAPGHVADFLVADFRRRGVDVSQVAWQSKGDTPSSCCIINNSNGNRTIVLHDTSLPDV
SATDFEKVDLTQFKWIHIEGRNASEQVKMLQRIDAHNTRQPPEQKIRVSVEVEKPREELF
QLFGYGDVVFVSKDVAKHLGFQSAEEALRGLYGRVRKGAVLVCAWAEEGADALGPDGKLL
HSDAFPPPRVVDTLGAGDTFNASVIFSLSQGRSVQEALRFGCQVAGKKCGLQGFDGIV
|
|
|
BDBM319582 |
---|
n/a |
---|
Name | BDBM319582 |
Synonyms: | US10174007, Example 1 | US10787438, Example 1 | US10988463, Example 1 | US11634410, Example 1 |
Type | Small organic molecule |
Emp. Form. | C18H19F3N4O3 |
Mol. Mass. | 396.3637 |
SMILES | C[C@H]1[C@H](O)CN1c1nc(cc(c1C#N)C(F)(F)F)N1C[C@H]2[C@H](CC(O)=O)[C@H]2C1 |r| |
Structure |
|