Ki Summary

Reaction Details

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Target

Tyrosine-protein kinase JAK1 [574-1154]

Ligand

BDBM505104

Substrate/Competitor

n/a

Meas. Tech.

Enzymatic Inhibition Assay

IC50

<0.200±n/a nM

Citation

Fernandes, P; Krawczuk, PJ; Tichenor, MS Small molecule inhibitors of the JAK family of kinases US Patent US11066406 Publication Date 7/20/2021

More Info.:

Get all data from this article, Assay Method

Tyrosine-protein kinase JAK1 [574-1154]

Name:

Tyrosine-protein kinase JAK1 [574-1154]

Synonyms:

JAK1 | JAK1 (aa 574-1154) | JAK1A | JAK1B | JAK1_HUMAN

Type:

Protein

Mol. Mass.:

66641.39

Organism:

Homo sapiens (Human)

Description:

P23458[574-1154]

Residue:

581

Sequence:

SFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISL
AFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFK
VAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECI
ERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPV
TPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKR
FLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLY
HENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDY
LGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECL
MQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKR
LPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK

BDBM505104

n/a

Name

BDBM505104

Synonyms:

US11066406, A

Type

Small organic molecule

Emp. Form.

C17H18N4

Mol. Mass.

278.3516

SMILES

Cc1nc2ccc3[nH]ccc3c2n1C1CCC(CC1)C#N |(-3.94,3.43,;-3.62,1.92,;-4.65,.77,;-3.88,-.56,;-4.35,-2.02,;-3.32,-3.17,;-1.82,-2.85,;-.57,-3.75,;.68,-2.85,;.2,-1.38,;-1.34,-1.38,;-2.37,-.24,;-2.21,1.29,;-.88,2.06,;-.88,3.6,;.46,4.37,;1.79,3.6,;1.79,2.06,;.46,1.29,;3.13,4.37,;3.13,5.91,)|

Structure