Reaction Details | |||
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Target | Non-receptor tyrosine-protein kinase TYK2 [580-1182] | ||
Ligand | BDBM505104 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Enzymatic Inhibition Assay | ||
IC50 | 0.900±n/a nM | ||
Citation | Fernandes, P; Krawczuk, PJ; Tichenor, MS Small molecule inhibitors of the JAK family of kinases US Patent US11066406 Publication Date 7/20/2021 | ||
More Info.: | Get all data from this article, Assay Method | ||
Non-receptor tyrosine-protein kinase TYK2 [580-1182] | |||
Name: | Non-receptor tyrosine-protein kinase TYK2 [580-1182] | ||
Synonyms: | TYK2 | TYK2 (aa 580-1182) | TYK2_HUMAN | ||
Type: | n/a | ||
Mol. Mass.: | 68754.63 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P29597[580-1182] | ||
Residue: | 608 | ||
Sequence: |
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BDBM505104 | |||
n/a | |||
Name | BDBM505104 | ||
Synonyms: | US11066406, A | ||
Type | Small organic molecule | ||
Emp. Form. | C17H18N4 | ||
Mol. Mass. | 278.3516 | ||
SMILES | Cc1nc2ccc3[nH]ccc3c2n1C1CCC(CC1)C#N |(-3.94,3.43,;-3.62,1.92,;-4.65,.77,;-3.88,-.56,;-4.35,-2.02,;-3.32,-3.17,;-1.82,-2.85,;-.57,-3.75,;.68,-2.85,;.2,-1.38,;-1.34,-1.38,;-2.37,-.24,;-2.21,1.29,;-.88,2.06,;-.88,3.6,;.46,4.37,;1.79,3.6,;1.79,2.06,;.46,1.29,;3.13,4.37,;3.13,5.91,)| | ||
Structure |