Ki Summary

Reaction Details

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Target

Tyrosine-protein kinase JAK2 [532-1132]

Ligand

BDBM505106

Substrate/Competitor

n/a

Meas. Tech.

Enzymatic Inhibition Assay

IC50

0.600±n/a nM

Citation

Fernandes, P; Krawczuk, PJ; Tichenor, MS Small molecule inhibitors of the JAK family of kinases US Patent US11066406 Publication Date 7/20/2021

More Info.:

Get all data from this article, Assay Method

Tyrosine-protein kinase JAK2 [532-1132]

Name:

Tyrosine-protein kinase JAK2 [532-1132]

Synonyms:

JAK2 | JAK2 (aa 532-1132) | JAK2_HUMAN

Type:

Protein

Mol. Mass.:

69777.30

Organism:

Homo sapiens (Human)

Description:

O60674[532-1132]

Residue:

601

Sequence:

MNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYS
ESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKL
EVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDI
LQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQ
LPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALG
FSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEH
LRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHI
KLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVK
EPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQG
QMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMA
G

BDBM505106

n/a

Name

BDBM505106

Synonyms:

US11066406, C

Type

Small organic molecule

Emp. Form.

C18H20N4O

Mol. Mass.

308.3776

SMILES

C[C@H](O)c1nc2ccc3[nH]ccc3c2n1C1CCC(CC1)C#N |r,wU:1.1,(-2.79,4.46,;-3.94,3.43,;-5.4,3.9,;-3.62,1.92,;-4.65,.77,;-3.88,-.56,;-4.35,-2.02,;-3.32,-3.17,;-1.82,-2.85,;-.57,-3.75,;.68,-2.85,;.2,-1.38,;-1.34,-1.38,;-2.37,-.24,;-2.21,1.29,;-.88,2.06,;-.88,3.6,;.46,4.37,;1.79,3.6,;1.79,2.06,;.46,1.29,;3.13,4.37,;3.13,5.91,)|

Structure