| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase JAK1 [574-1154] |
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| Ligand | BDBM505112 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Enzymatic Inhibition Assay |
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| IC50 | 0.100±n/a nM |
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| Citation |  Fernandes, P; Krawczuk, PJ; Tichenor, MS Small molecule inhibitors of the JAK family of kinases US Patent US11066406 Publication Date 7/20/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase JAK1 [574-1154] |
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| Name: | Tyrosine-protein kinase JAK1 [574-1154] |
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| Synonyms: | JAK1 | JAK1 (aa 574-1154) | JAK1A | JAK1B | JAK1_HUMAN |
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| Type: | Protein |
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| Mol. Mass.: | 66641.39 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P23458[574-1154] |
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| Residue: | 581 |
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| Sequence: | SFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISL
AFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFK
VAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECI
ERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPV
TPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKR
FLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLY
HENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDY
LGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECL
MQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKR
LPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK
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| BDBM505112 |
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| n/a |
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| Name | BDBM505112 |
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| Synonyms: | US11066406, Ex. 6 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H30N6O2 |
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| Mol. Mass. | 434.534 |
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| SMILES | O=C(Cc1nc2cnc3[nH]ccc3c2n1C1(CC#N)CCCCC1)NCC1CCOCC1 |
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| Structure | 
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