Ki Summary

Reaction Details

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Target

Tyrosine-protein kinase JAK2 [532-1132]

Ligand

BDBM505113

Substrate/Competitor

n/a

Meas. Tech.

Enzymatic Inhibition Assay

IC50

5.60±n/a nM

Citation

Fernandes, P; Krawczuk, PJ; Tichenor, MS Small molecule inhibitors of the JAK family of kinases US Patent US11066406 Publication Date 7/20/2021

More Info.:

Get all data from this article, Assay Method

Tyrosine-protein kinase JAK2 [532-1132]

Name:

Tyrosine-protein kinase JAK2 [532-1132]

Synonyms:

JAK2 | JAK2 (aa 532-1132) | JAK2_HUMAN

Type:

Protein

Mol. Mass.:

69777.30

Organism:

Homo sapiens (Human)

Description:

O60674[532-1132]

Residue:

601

Sequence:

MNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYS
ESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKL
EVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDI
LQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQ
LPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALG
FSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEH
LRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHI
KLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVK
EPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQG
QMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMA
G

BDBM505113

n/a

Name

BDBM505113

Synonyms:

US11066406, Ex. 7

Type

Small organic molecule

Emp. Form.

C23H27N7O

Mol. Mass.

417.5068

SMILES

CC(C)(CNC(=O)Cc1nc2cnc3[nH]ccc3c2n1C1CCC(CC#N)CC1)C#N |(12.86,2.75,;12.09,1.42,;11.32,.08,;10.75,2.19,;9.42,1.42,;8.08,2.19,;8.08,3.73,;6.75,1.42,;5.42,2.19,;5.26,3.72,;3.75,4.04,;2.98,5.37,;1.44,5.37,;.67,4.04,;-.84,3.72,;-1,2.19,;.41,1.56,;1.44,2.71,;2.98,2.71,;4.01,1.56,;3.69,.06,;4.83,-.98,;4.51,-2.48,;3.05,-2.96,;2.73,-4.46,;1.26,-4.94,;-.2,-5.42,;1.91,-1.93,;2.23,-.42,;13.42,.65,;14.75,-.12,)|

Structure