Ki Summary

Reaction Details

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Target

Tyrosine-protein kinase JAK1 [574-1154]

Ligand

BDBM505118

Substrate/Competitor

n/a

Meas. Tech.

Enzymatic Inhibition Assay

IC50

0.900±n/a nM

Citation

Fernandes, P; Krawczuk, PJ; Tichenor, MS Small molecule inhibitors of the JAK family of kinases US Patent US11066406 Publication Date 7/20/2021

More Info.:

Get all data from this article, Assay Method

Tyrosine-protein kinase JAK1 [574-1154]

Name:

Tyrosine-protein kinase JAK1 [574-1154]

Synonyms:

JAK1 | JAK1 (aa 574-1154) | JAK1A | JAK1B | JAK1_HUMAN

Type:

Protein

Mol. Mass.:

66641.39

Organism:

Homo sapiens (Human)

Description:

P23458[574-1154]

Residue:

581

Sequence:

SFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISL
AFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFK
VAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECI
ERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPV
TPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKR
FLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLY
HENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDY
LGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECL
MQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKR
LPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK

BDBM505118

n/a

Name

BDBM505118

Synonyms:

US11066406, Ex. 12

Type

Small organic molecule

Emp. Form.

C22H26N6O2

Mol. Mass.

406.4808

SMILES

OC1(CNC(=O)Cc2nc3cnc4[nH]ccc4c3n2C2CCC(CC#N)CC2)CC1 |(5.23,6.31,;6.75,6.04,;6.75,4.5,;8.08,3.73,;8.08,2.19,;9.42,1.42,;6.75,1.42,;5.42,2.19,;5.26,3.72,;3.75,4.04,;2.98,5.37,;1.44,5.37,;.67,4.04,;-.84,3.72,;-1,2.19,;.41,1.56,;1.44,2.71,;2.98,2.71,;4.01,1.56,;3.69,.06,;2.23,-.42,;1.91,-1.93,;3.05,-2.96,;2.73,-4.46,;3.87,-5.49,;5.02,-6.52,;4.51,-2.48,;4.83,-.98,;7.28,7.48,;8.27,6.31,)|

Structure