| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase BTK [328-659] |
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| Ligand | BDBM514882 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Microfluidic Off-Chip Mobility Shift Assay Protocol for Potency Assessment Against BTK C481S Enzyme |
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| IC50 | <100±n/a nM |
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| Citation |  Gaillard, P; Seenisamy, J; Liu-Bujalski, L; Caldwell, RD; Potnick, J; Qiu, H; Neagu, C; Jones, R; Won, AC; Goutopoulos, A; Sherer, BA; Johnson, TL; Gardberg, A Heteroaryl compounds as BTK inhibitors and uses thereof US Patent US11098041 Publication Date 8/24/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase BTK [328-659] |
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| Name: | Tyrosine-protein kinase BTK [328-659] |
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| Synonyms: | AGMX1 | ATK | BPK | BTK | BTK_HUMAN | Tyrosine-protein kinase BTK (328-659) |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 38470.67 |
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| Organism: | Homo sapiens (Human) |
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| Description: | aa 328-659 |
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| Residue: | 332 |
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| Sequence: | QGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPST
AGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAK
VMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCE
AMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPE
VLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVY
TIMYSCWHEKADERPTFKILLSNILDVMDEES
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| BDBM514882 |
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| n/a |
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| Name | BDBM514882 |
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| Synonyms: | US11098041, Example 107 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H30N6O |
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| Mol. Mass. | 478.5881 |
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| SMILES | Cc1cc(ccc1CNC(=O)c1ccc(cc1)C(C)(C)C)-c1ccnc2[nH]c(nc12)-c1cnn(C)c1 |
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| Structure | 
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