| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Mitogen-activated protein kinase kinase kinase kinase 1 |
|---|
| Ligand | BDBM519602 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | HPK1 Biochemical Enzyme Assay |
|---|
| Ki | <0.050±n/a nM |
|---|
| Citation |  Gallego, RA; Nair, SK; Kania, RS; Ahmad, OK; Johnson, TW; Tuttle, JB; Jalaie, M; McTigue, MA; Zhou, D; Del Bel, ML; Zhou, R; He, M; Schmitt, AD Azalactam compounds as HPK1 inhibitors US Patent US11142525 Publication Date 10/12/2021 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Mitogen-activated protein kinase kinase kinase kinase 1 |
|---|
| Name: | Mitogen-activated protein kinase kinase kinase kinase 1 |
|---|
| Synonyms: | HPK1 | M4K1_HUMAN | MAP4K1 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 91316.07 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_586597 |
|---|
| Residue: | 833 |
|---|
| Sequence: | MDVVDPDIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQ
KEILILKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCRE
VLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMA
PEVAAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEK
GKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSI
GDIEDEEPELPPAIPRRIRSTHRSSSLGIPDADCCRRHMEFRKLRGMETRPPANTARLQP
PRDLRSSSPRKQLSESSDDDYDDVDIPTPAEDTPPPLPPKPKFRSPSDEGPGSMGDDGQL
SPGVLVRCASGPPPNSPRPGPPPSTSSPHLTAHSEPSLWNPPSRELDKPPLLPPKKEKMK
RKGCALLVKLFNGCPLRIHSTAAWTHPSTKDQHLLLGAEEGIFILNRNDQEATLEMLFPS
RTTWVYSINNVLMSLSGKTPHLYSHSILGLLERKETRAGNPIAHISPHRLLARKNMVSTK
IQDTKGCRACCVAEGASSGGPFLCGALETSVVLLQWYQPMNKFLLVRQVLFPLPTPLSVF
ALLTGPGSELPAVCIGVSPGRPGKSVLFHTVRFGALSCWLGEMSTEHRGPVQVTQVEEDM
VMVLMDGSVKLVTPEGSPVRGLRTPEIPMTEAVEAVAMVGGQLQAFWKHGVQVWALGSDQ
LLQELRDPTLTFRLLGSPRLECSGTISPHCNLLLPGSSNSPASASRVAGITGL
|
|
|
|---|
| BDBM519602 |
|---|
| n/a |
|---|
| Name | BDBM519602 |
|---|
| Synonyms: | US11142525, Example 18 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H27F3N8O |
|---|
| Mol. Mass. | 488.5087 |
|---|
| SMILES | CC[C@@H](CC(F)(F)F)n1cnnc1-c1cccc(n1)N1Cc2c(cc(nc2CNC)N(C)C)C1=O |r| |
|---|
| Structure | 
|
|---|
Search and Browse
