| Reaction Details |
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 | Report a problem with these data |
| Target | Genome polyprotein |
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| Ligand | BDBM521555 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Rhinovirus Polymerase (HRV1bpol) and HCV Polymerase (HCVpol) Assays |
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| IC50 | 130±n/a nM |
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| Citation |  Beigelman, L; Deval, J; Prhavc, M Substituted nucleosides, nucleotides and analogs thereof US Patent US11149049 Publication Date 10/19/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| Genome polyprotein |
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| Name: | Genome polyprotein |
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| Synonyms: | POLG_HRV16 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 242260.90 |
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| Organism: | Human rhinovirus 16 |
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| Description: | ChEMBL_523531 |
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| Residue: | 2153 |
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| Sequence: | MGAQVSRQNVGTHSTQNMVSNGSSLNYFNINYFKDAASSGASRLDFSQDPSKFTDPVKDV
LEKGIPTLQSPSVEACGYSDRIIQITRGDSTITSQDVANAVVGYGVWPHYLTPQDATAID
KPTQPDTSSNRFYTLDSKMWNSTSKGWWWKLPDALKDMGIFGENMFYHFLGRSGYTVHVQ
CNASKFHQGTLLVVMIPEHQLATVNKGNVNAGYKYTHPGEAGREVGTQVENEKQPSDDNW
LNFDGTLLGNLLIFPHQFINLRSNNSATLIVPYVNAVPMDSMVRHNNWSLVIIPVCQLQS
NNISNIVPITVSISPMCAEFSGARAKTVVQGLPVYVTPGSGQFMTTDDMQSPCALPWYHP
TKEIFIPGEVKNLIEMCQVDTLIPINSTQSNIGNVSMYTVTLSPQTKLAEEIFAIKVDIA
SHPLATTLIGEIASYFTHWTGSLRFSFMFCGTANTTLKVLLAYTPPGIGKPRSRKEAMLG
THVVWDVGLQSTVSLVVPWISASQYRFTTPDTYSSAGYITCWYQTNFVVPPNTPNTAEML
CFVSGCKDFCLRMARDTDLHKQTGPITQNPVERYVDEVLNEVLVVPNINQSHPTTSNAAP
VLDAAETGHTNKIQPEDTIETRYVQSSQTLDEMSVESFLGRSGCIHESVLDIVDNYNDQS
FTKWNINLQEMAQIRRKFEMFTYARFDSEITMVPSVAAKDGHIGHIVMQYMYVPPGAPIP
TTRDDYAWQSGTNASVFWQHGQPFPRFSLPFLSIASAYYMFYDGYDGDTYKSRYGTVVTN
DMGTLCSRIVTSEQLHKVKVVTRIYHKAKHTKAWCPRPPRAVQYSHTHTTNYKLSSEVHN
DVAIRPRTNLTTVGPSDMYVHVGNLIYRNLHLFNSDIHDSILVSYSSDLIIYRTSTQGDG
YIPTCNCTEATYYCKHKNRYYPINVTPHDWYEIQESEYYPKHIQYNLLIGEGPCEPGDCG
GKLLCKHGVIGIITAGGEGHVAFIDLRHFHCAEEQGITDYIHMLGEAFGSGFVDSVKDQI
NSINPINNISSKMVKWMLRIISAMVIIIRNSSDPQTIIATLTLIGCNGSPWRFLKEKFCK
WTQLTYIHKESDSWLKKFTEMCNAARGLEWIGNKISKFIDWMKSMLPQAQLKVKYLSELK
KLNFLEKQVENLRAADTNTQEKIKCEIDTLHDLSCKFLPLYASEAKRIKVLYHKCTNIIK
QKKRSEPVAVMIHGPPGTGKSITTSFLARMITNESDIYSLPPDPKYFDGYDNQSVVIMDD
IMQNPGGEDMTLFCQMVSSVTFIPPMADLPDKGKPFDSRFVLCSTNHSLLAPPTISSLPA
MNRRFYLDLDILVHDNYKDNQGKLDVSRAFRLCDVDSKIGNAKCCPFVCGKAVTFKDRNT
CRTYSLSQIYNQILEEDKRRRQVVDVMSAIFQGPISMDKPPPPAITDLLRSVRTPEVIKY
CQDNKWIVPADCQIERDLNIANSIITIIANIISIAGIIYIIYKLFCSLQGPYSGEPKPKT
KVPERRVVAQGPEEEFGMSIIKNNTCVVTTTNGKFTGLGIYDRILILPTHADPGSEIQVN
GIHTKVLDSYDLFNKEGVKLEITVLKLDRNEKFRDIRKYIPESEDDYPECNLALVANQTE
PTIIKVGDVVSYGNILLSGTQTARMLKYNYPTKSGYCGGVLYKIGQILGIHVGGNGRDGF
SSMLLRSYFTEQQGQIQISKHVKDVGLPSIHTPTKTKLQPSVFYDIFPGSKEPAVLTEKD
PRLKVDFDSALFSKYKGNTECSLNEHIQVAVAHYSAQLATLDIDPQPIAMEDSVFGMDGL
EALDLNTSAGYPYVTLGIKKKDLINNKTKDISKLKLALDKYDVDLPMITFLKDELRKKDK
IAAGKTRVIEASSINDTILFRTVYGNLFSKFHLNPGVVTGCAVGCDPETFWSKIPLMLDG
DCIMAFDYTNYDGSIHPIWFKALGMVLDNLSFNPTLINRLCNSKHIFKSTYYEVEGGVPS
GCSGTSIFNSMINNIIIRTLVLDAYKHIDLDKLKIIAYGDDVIFSYKYKLDMEAIAKEGQ
KYGLTITPADKSSEFKELDYGNVTFLKRGFRQDDKYKFLIHPTFPVEEIYESIRWTKKPS
QMQEHVLSLCHLMWHNGPEIYKDFETKIRSVSAGRALYIPPYELLRHEWYEKF
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| BDBM521555 |
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| n/a |
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| Name | BDBM521555 |
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| Synonyms: | ((2S,3S,4R,5R)-5-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-2-fluoro-3,4-dihydroxytetrahydrofuran-2-yl)methyl tetrahydrogen triphosphate | US11149049, No. 12 |
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| Type | Small organic molecule |
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| Emp. Form. | C12H15FN5O13P3 |
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| Mol. Mass. | 549.1929 |
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| SMILES | Nc1ncnn2c(ccc12)[C@@]1(O[C@](F)(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O)C#N |r| |
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| Structure | 
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