Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Reverse transcriptase/RNaseH (Human immunodeficiency virus 1) | BDBM50164644 (2',3'-Dideoxyadenosine Triphosphate (Ddatp) | 2',3...) | PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Biota, Inc. Curated by ChEMBL | Assay Description Inhibitory constant against HIV-1 reverse transcriptase | J Med Chem 48: 2695-700 (2005) Article DOI: 10.1021/jm040101y BindingDB Entry DOI: 10.7270/Q2G73FG5 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Reverse transcriptase/RNaseH (Human immunodeficiency virus 1) | BDBM50164642 (2',3'-Dideoxynucleoside5'-alpha-P-Borano-beta,gamm...) | PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 23 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Biota, Inc. Curated by ChEMBL | Assay Description Inhibitory constant against HIV-1 reverse transcriptase | J Med Chem 48: 2695-700 (2005) Article DOI: 10.1021/jm040101y BindingDB Entry DOI: 10.7270/Q2G73FG5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Reverse transcriptase/RNaseH (Human immunodeficiency virus 1) | BDBM50164639 (2'-3'-dideoxy-7-deaza-guaninetriphosphate | CHEMBL...) | PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem | Article PubMed | 25 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Biota, Inc. Curated by ChEMBL | Assay Description Inhibitory constant against HIV-1 reverse transcriptase | J Med Chem 48: 2695-700 (2005) Article DOI: 10.1021/jm040101y BindingDB Entry DOI: 10.7270/Q2G73FG5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Reverse transcriptase/RNaseH (Human immunodeficiency virus 1) | BDBM50164652 (2',3'-Dideoxynucleoside5'-alpha-P-Borano-beta,gamm...) | PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | 34 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Biota, Inc. Curated by ChEMBL | Assay Description Inhibitory constant against HIV-1 reverse transcriptase | J Med Chem 48: 2695-700 (2005) Article DOI: 10.1021/jm040101y BindingDB Entry DOI: 10.7270/Q2G73FG5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Reverse transcriptase/RNaseH (Human immunodeficiency virus 1) | BDBM50164654 (CHEMBL370031 | [[[4-(2-amino-6-oxo-3,9-dihydropuri...) | PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | Article PubMed | 37 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Biota, Inc. Curated by ChEMBL | Assay Description Inhibitory constant against HIV-1 reverse transcriptase | J Med Chem 48: 2695-700 (2005) Article DOI: 10.1021/jm040101y BindingDB Entry DOI: 10.7270/Q2G73FG5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Reverse transcriptase/RNaseH (Human immunodeficiency virus 1) | BDBM50164637 (2',3'-Dideoxynucleoside5'-alpha-P-Borano-beta,gamm...) | PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 45 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Biota, Inc. Curated by ChEMBL | Assay Description Inhibitory constant against HIV-1 reverse transcriptase | J Med Chem 48: 2695-700 (2005) Article DOI: 10.1021/jm040101y BindingDB Entry DOI: 10.7270/Q2G73FG5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Reverse transcriptase/RNaseH (Human immunodeficiency virus 1) | BDBM50164638 (2',3'-Dideoxynucleoside5'-alpha-P-Borano-beta,gamm...) | PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 46 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Biota, Inc. Curated by ChEMBL | Assay Description Inhibitory constant against HIV-1 reverse transcriptase | J Med Chem 48: 2695-700 (2005) Article DOI: 10.1021/jm040101y BindingDB Entry DOI: 10.7270/Q2G73FG5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Reverse transcriptase/RNaseH (Human immunodeficiency virus 1) | BDBM50164647 (2',3'-Dideoxynucleoside5'-alpha-P-Borano-beta,gamm...) | PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 47 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Biota, Inc. Curated by ChEMBL | Assay Description Inhibitory constant against HIV-1 reverse transcriptase | J Med Chem 48: 2695-700 (2005) Article DOI: 10.1021/jm040101y BindingDB Entry DOI: 10.7270/Q2G73FG5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Reverse transcriptase/RNaseH (Human immunodeficiency virus 1) | BDBM50145605 (4-amino-1-[(2R,5S)-5-(hydroxymethyl)tetrahydrofura...) | PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid UniChem Patents Similars | DrugBank Article PubMed | 51 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Biota, Inc. Curated by ChEMBL | Assay Description Inhibitory constant against HIV-1 reverse transcriptase | J Med Chem 48: 2695-700 (2005) Article DOI: 10.1021/jm040101y BindingDB Entry DOI: 10.7270/Q2G73FG5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Reverse transcriptase/RNaseH (Human immunodeficiency virus 1) | BDBM50370655 (CHEMBL485652) | PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid PDB UniChem Similars | PDB Article PubMed | 56 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Biota, Inc. Curated by ChEMBL | Assay Description Inhibitory constant against HIV-1 reverse transcriptase | J Med Chem 48: 2695-700 (2005) Article DOI: 10.1021/jm040101y BindingDB Entry DOI: 10.7270/Q2G73FG5 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Reverse transcriptase/RNaseH (Human immunodeficiency virus 1) | BDBM50164648 (2'-deoxythymidine triphosphate | 5'-TTP | CHEMBL36...) | PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 61 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Biota, Inc. Curated by ChEMBL | Assay Description Inhibitory constant against HIV-1 reverse transcriptase | J Med Chem 48: 2695-700 (2005) Article DOI: 10.1021/jm040101y BindingDB Entry DOI: 10.7270/Q2G73FG5 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Reverse transcriptase/RNaseH (Human immunodeficiency virus 1) | BDBM50164650 (CHEMBL191725 | [[[3-fluoro-5-(5-methyl-2,4-dioxo-1...) | PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | 71 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Biota, Inc. Curated by ChEMBL | Assay Description Inhibitory constant against HIV-1 reverse transcriptase | J Med Chem 48: 2695-700 (2005) Article DOI: 10.1021/jm040101y BindingDB Entry DOI: 10.7270/Q2G73FG5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Reverse transcriptase/RNaseH (Human immunodeficiency virus 1) | BDBM50164653 (2',3'-Dideoxynucleoside5'-alpha-P-Borano-beta,gamm...) | PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 71 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Biota, Inc. Curated by ChEMBL | Assay Description Inhibitory constant against HIV-1 reverse transcriptase | J Med Chem 48: 2695-700 (2005) Article DOI: 10.1021/jm040101y BindingDB Entry DOI: 10.7270/Q2G73FG5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Reverse transcriptase/RNaseH (Human immunodeficiency virus 1) | BDBM50370476 (Combivir | ZIDOVUDINE TRIPHOSPHATE) | PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | Purchase MCE KEGG PC cid PC sid PDB UniChem Similars | PDB Article PubMed | 91 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Biota, Inc. Curated by ChEMBL | Assay Description Inhibitory constant against HIV-1 reverse transcriptase | J Med Chem 48: 2695-700 (2005) Article DOI: 10.1021/jm040101y BindingDB Entry DOI: 10.7270/Q2G73FG5 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Reverse transcriptase/RNaseH (Human immunodeficiency virus 1) | BDBM50164640 (CHEMBL190609 | [[[[3-azido-5-(5-methyl-2,4-dioxo-1...) | PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 94 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Biota, Inc. Curated by ChEMBL | Assay Description Inhibitory constant against HIV-1 reverse transcriptase | J Med Chem 48: 2695-700 (2005) Article DOI: 10.1021/jm040101y BindingDB Entry DOI: 10.7270/Q2G73FG5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Reverse transcriptase/RNaseH (Human immunodeficiency virus 1) | BDBM50138406 (3TC Triphosphate | CHEMBL1230 | LAMIVUDINE | Lamiv...) | PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Similars | PDB Article PubMed | 188 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Biota, Inc. Curated by ChEMBL | Assay Description Inhibitory constant against HIV-1 reverse transcriptase | J Med Chem 48: 2695-700 (2005) Article DOI: 10.1021/jm040101y BindingDB Entry DOI: 10.7270/Q2G73FG5 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Reverse transcriptase/RNaseH (Human immunodeficiency virus 1) | BDBM50164655 (2',3'-Dideoxynucleoside5'-alpha-P-Borano-beta,gamm...) | PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 236 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Biota, Inc. Curated by ChEMBL | Assay Description Inhibitory constant against HIV-1 reverse transcriptase | J Med Chem 48: 2695-700 (2005) Article DOI: 10.1021/jm040101y BindingDB Entry DOI: 10.7270/Q2G73FG5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Reverse transcriptase/RNaseH (Human immunodeficiency virus 1) | BDBM50164651 (2',3'-Dideoxynucleoside5'-alpha-P-Borano-beta,gamm...) | PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 314 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Biota, Inc. Curated by ChEMBL | Assay Description Inhibitory constant against HIV-1 reverse transcriptase | J Med Chem 48: 2695-700 (2005) Article DOI: 10.1021/jm040101y BindingDB Entry DOI: 10.7270/Q2G73FG5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Reverse transcriptase/RNaseH (Human immunodeficiency virus 1) | BDBM50164656 (2',3'-Dideoxynucleoside5'-alpha-P-Borano-beta,gamm...) | PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 438 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Biota, Inc. Curated by ChEMBL | Assay Description Inhibitory constant against HIV-1 reverse transcriptase | J Med Chem 48: 2695-700 (2005) Article DOI: 10.1021/jm040101y BindingDB Entry DOI: 10.7270/Q2G73FG5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Reverse transcriptase/RNaseH (Human immunodeficiency virus 1) | BDBM50164645 (CHEMBL192771 | [[[5-(4-amino-5-fluoro-2-oxo-1H-pyr...) | PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | 501 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Biota, Inc. Curated by ChEMBL | Assay Description Inhibitory constant against HIV-1 reverse transcriptase | J Med Chem 48: 2695-700 (2005) Article DOI: 10.1021/jm040101y BindingDB Entry DOI: 10.7270/Q2G73FG5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Reverse transcriptase/RNaseH (Human immunodeficiency virus 1) | BDBM50164646 (CHEMBL192371 | [[[5-(2,4-dioxo-1H-pyrimidin-1-yl)t...) | PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | 545 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Biota, Inc. Curated by ChEMBL | Assay Description Inhibitory constant against HIV-1 reverse transcriptase | J Med Chem 48: 2695-700 (2005) Article DOI: 10.1021/jm040101y BindingDB Entry DOI: 10.7270/Q2G73FG5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Reverse transcriptase/RNaseH (Human immunodeficiency virus 1) | BDBM50164643 (({[({[5-(4-amino-5-fluoro-2-oxo-1,2-dihydropyrimid...) | PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1.77E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Biota, Inc. Curated by ChEMBL | Assay Description Inhibitory constant against HIV-1 reverse transcriptase | J Med Chem 48: 2695-700 (2005) Article DOI: 10.1021/jm040101y BindingDB Entry DOI: 10.7270/Q2G73FG5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RNA-directed RNA polymerase (Hepatitis C virus) | BDBM50274121 (CHEMBL4127092) | PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen BioPharma, Inc. Curated by ChEMBL | Assay Description Inhibition of HCV NS5B RNA-dependent RNA polymerase activity assessed as reduction in radiolabeled-UTP incorporation into RNA using cIRES template me... | J Med Chem 62: 4555-4570 (2019) Article DOI: 10.1021/acs.jmedchem.9b00143 BindingDB Entry DOI: 10.7270/Q2DB858G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Rous sarcoma virus integrase (Rous sarcoma virus (strain Prague C) (RSV-PrC)) | BDBM521555 (((2S,3S,4R,5R)-5-(4-Aminopyrrolo[2,1-f][1,2,4]tria...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | KEGG PC cid PC sid UniChem | US Patent | n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Standard RSV polymerase assays were conducted in the presence of 3 μL extract of RSV-infected cells in a reaction buffer containing 50 mM tris-a... | Citation and Details BindingDB Entry DOI: 10.7270/Q28P63PG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Rous sarcoma virus integrase (Rous sarcoma virus (strain Prague C) (RSV-PrC)) | BDBM521557 (((2R,3S,4R,5R)-5-(4-Aminopyrrolo[2,1-f][1,2,4]tria...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | KEGG PC cid PC sid UniChem | US Patent | n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Standard RSV polymerase assays were conducted in the presence of 3 μL extract of RSV-infected cells in a reaction buffer containing 50 mM tris-a... | Citation and Details BindingDB Entry DOI: 10.7270/Q28P63PG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RNA-directed RNA polymerase (Hepatitis C virus) | BDBM50274124 (CHEMBL4125966 | US10793591, Compound 12) | PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 39 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen BioPharma, Inc. Curated by ChEMBL | Assay Description Inhibition of HCV NS5B RNA-dependent RNA polymerase activity assessed as reduction in radiolabeled-UTP incorporation into RNA using cIRES template me... | J Med Chem 62: 4555-4570 (2019) Article DOI: 10.1021/acs.jmedchem.9b00143 BindingDB Entry DOI: 10.7270/Q2DB858G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein (Human rhinovirus 16) | BDBM521557 (((2R,3S,4R,5R)-5-(4-Aminopyrrolo[2,1-f][1,2,4]tria...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | KEGG PC cid PC sid UniChem | US Patent | n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The enzyme activity of hepatitis C virus RNA polymerase (HCVpol) and human rhinovirus 16 RNA polymerase (HRV16pol) is measured as an incorporation of... | Citation and Details BindingDB Entry DOI: 10.7270/Q28P63PG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RNA-directed RNA polymerase (Hepatitis C virus) | BDBM50544633 (CHEMBL4641646) | PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | KEGG PC cid PC sid UniChem | Article PubMed | n/a | n/a | 64 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen BioPharma, Inc. Curated by ChEMBL | Assay Description Inhibition of HCV NS5B RNA-dependent RNA polymerase activity assessed as reduction in radiolabeled ribonucleotide monophosphates incorporation into R... | J Med Chem 63: 10380-10395 (2020) Article DOI: 10.1021/acs.jmedchem.0c00935 BindingDB Entry DOI: 10.7270/Q2TM7FP8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RNA-directed RNA polymerase (Hepatitis C virus) | BDBM50332459 (((2R,3R,4R,5R)-5-(2-amino-6-oxo-1H-purin-9(6H)-yl)...) | PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 99 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen BioPharma, Inc. Curated by ChEMBL | Assay Description Inhibition of HCV NS5B RNA-dependent RNA polymerase activity assessed as reduction in radiolabeled ribonucleotide monophosphates incorporation into R... | J Med Chem 63: 10380-10395 (2020) Article DOI: 10.1021/acs.jmedchem.0c00935 BindingDB Entry DOI: 10.7270/Q2TM7FP8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RNA-directed RNA polymerase (Hepatitis C virus) | BDBM50524197 (CHEMBL4555315 | US10793591, Compound 46) | PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | KEGG PC cid PC sid UniChem | Article PubMed | n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen BioPharma, Inc. Curated by ChEMBL | Assay Description Inhibition of HCV NS5B RNA-dependent RNA polymerase activity assessed as reduction in radiolabeled-UTP incorporation into RNA using cIRES template me... | J Med Chem 62: 4555-4570 (2019) Article DOI: 10.1021/acs.jmedchem.9b00143 BindingDB Entry DOI: 10.7270/Q2DB858G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Rous sarcoma virus integrase (Rous sarcoma virus (strain Prague C) (RSV-PrC)) | BDBM50236025 (CHEMBL2016761 | US11149049, No. C2) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Similars | US Patent | n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Standard RSV polymerase assays were conducted in the presence of 3 μL extract of RSV-infected cells in a reaction buffer containing 50 mM tris-a... | Citation and Details BindingDB Entry DOI: 10.7270/Q28P63PG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RNA-directed RNA polymerase (Hepatitis C virus) | BDBM50544634 (CHEMBL4632955) | PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | KEGG PC cid PC sid UniChem | Article PubMed | n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen BioPharma, Inc. Curated by ChEMBL | Assay Description Inhibition of HCV NS5B RNA-dependent RNA polymerase activity assessed as reduction in radiolabeled ribonucleotide monophosphates incorporation into R... | J Med Chem 63: 10380-10395 (2020) Article DOI: 10.1021/acs.jmedchem.0c00935 BindingDB Entry DOI: 10.7270/Q2TM7FP8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RNA-directed RNA polymerase (Hepatitis C virus) | BDBM50144942 (2'-C-Me-guanosine | 2'-C-methyl-guanosine | 2'-C-m...) | PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
Isis Pharmaceuticals Curated by ChEMBL | Assay Description Inhibition HCV NS5B-mediated RNA synthesis | J Med Chem 47: 2283-95 (2004) Article DOI: 10.1021/jm030424e BindingDB Entry DOI: 10.7270/Q2QZ2BQ3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein (Human rhinovirus 16) | BDBM521555 (((2S,3S,4R,5R)-5-(4-Aminopyrrolo[2,1-f][1,2,4]tria...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | KEGG PC cid PC sid UniChem | US Patent | n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The enzyme activity of hepatitis C virus RNA polymerase (HCVpol) and human rhinovirus 16 RNA polymerase (HRV16pol) is measured as an incorporation of... | Citation and Details BindingDB Entry DOI: 10.7270/Q28P63PG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RNA-directed RNA polymerase (Hepatitis C virus) | BDBM50274118 (CHEMBL4127030 | US10793591, Compound 7a) | PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen BioPharma, Inc. Curated by ChEMBL | Assay Description Inhibition of HCV NS5B RNA-dependent RNA polymerase activity assessed as reduction in radiolabeled-UTP incorporation into RNA using cIRES template me... | J Med Chem 62: 4555-4570 (2019) Article DOI: 10.1021/acs.jmedchem.9b00143 BindingDB Entry DOI: 10.7270/Q2DB858G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RNA-directed RNA polymerase (Hepatitis C virus) | BDBM466313 (US10793591, Compound 9) | PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | KEGG PC cid PC sid UniChem | Article PubMed | n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen BioPharma, Inc. Curated by ChEMBL | Assay Description Inhibition of HCV NS5B RNA-dependent RNA polymerase activity assessed as reduction in radiolabeled ribonucleotide monophosphates incorporation into R... | J Med Chem 63: 10380-10395 (2020) Article DOI: 10.1021/acs.jmedchem.0c00935 BindingDB Entry DOI: 10.7270/Q2TM7FP8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RNA-directed RNA polymerase (Hepatitis C virus) | BDBM50524193 (CHEMBL4543543) | PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | KEGG PC cid PC sid UniChem | Article PubMed | n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen BioPharma, Inc. Curated by ChEMBL | Assay Description Inhibition of HCV NS5B RNA-dependent RNA polymerase activity assessed as reduction in radiolabeled-UTP incorporation into RNA using cIRES template me... | J Med Chem 62: 4555-4570 (2019) Article DOI: 10.1021/acs.jmedchem.9b00143 BindingDB Entry DOI: 10.7270/Q2DB858G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RNA-directed RNA polymerase (Hepatitis C virus) | BDBM466319 (US10793591, Compound 44) | PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | KEGG PC cid PC sid UniChem | Article PubMed | n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen BioPharma, Inc. Curated by ChEMBL | Assay Description Inhibition of HCV NS5B RNA-dependent RNA polymerase activity assessed as reduction in radiolabeled ribonucleotide monophosphates incorporation into R... | J Med Chem 63: 10380-10395 (2020) Article DOI: 10.1021/acs.jmedchem.0c00935 BindingDB Entry DOI: 10.7270/Q2TM7FP8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RNA-directed RNA polymerase (Hepatitis C virus) | BDBM50544635 (CHEMBL4640290) | PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | KEGG PC cid PC sid UniChem | Article PubMed | n/a | n/a | 160 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen BioPharma, Inc. Curated by ChEMBL | Assay Description Inhibition of HCV NS5B RNA-dependent RNA polymerase activity assessed as reduction in radiolabeled ribonucleotide monophosphates incorporation into R... | J Med Chem 63: 10380-10395 (2020) Article DOI: 10.1021/acs.jmedchem.0c00935 BindingDB Entry DOI: 10.7270/Q2TM7FP8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RNA-directed RNA polymerase (Hepatitis C virus) | BDBM50524191 (CHEMBL4592496) | PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | KEGG PC cid PC sid UniChem | Article PubMed | n/a | n/a | 190 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen BioPharma, Inc. Curated by ChEMBL | Assay Description Inhibition of HCV NS5B RNA-dependent RNA polymerase activity assessed as reduction in radiolabeled-UTP incorporation into RNA using cIRES template me... | J Med Chem 62: 4555-4570 (2019) Article DOI: 10.1021/acs.jmedchem.9b00143 BindingDB Entry DOI: 10.7270/Q2DB858G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein (Human rhinovirus 16) | BDBM521556 (((2R,3S,4R,5R)-5-(4-Aminopyrrolo[2,1-f][1,2,4]tria...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | KEGG PC cid PC sid UniChem | US Patent | n/a | n/a | 210 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The enzyme activity of hepatitis C virus RNA polymerase (HCVpol) and human rhinovirus 16 RNA polymerase (HRV16pol) is measured as an incorporation of... | Citation and Details BindingDB Entry DOI: 10.7270/Q28P63PG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein (Human rhinovirus 16) | BDBM50236025 (CHEMBL2016761 | US11149049, No. C2) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Similars | US Patent | n/a | n/a | 270 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The enzyme activity of hepatitis C virus RNA polymerase (HCVpol) and human rhinovirus 16 RNA polymerase (HRV16pol) is measured as an incorporation of... | Citation and Details BindingDB Entry DOI: 10.7270/Q28P63PG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RNA-directed RNA polymerase (Hepatitis C virus) | BDBM50524198 (CHEMBL4592592) | PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | KEGG PC cid PC sid UniChem | Article PubMed | n/a | n/a | 280 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen BioPharma, Inc. Curated by ChEMBL | Assay Description Inhibition of HCV NS5B RNA-dependent RNA polymerase activity assessed as reduction in radiolabeled-UTP incorporation into RNA using cIRES template me... | J Med Chem 62: 4555-4570 (2019) Article DOI: 10.1021/acs.jmedchem.9b00143 BindingDB Entry DOI: 10.7270/Q2DB858G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein (Hepatitis C virus (HCV genotype 1a, isolate H)) | BDBM521557 (((2R,3S,4R,5R)-5-(4-Aminopyrrolo[2,1-f][1,2,4]tria...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | KEGG PC cid PC sid UniChem | US Patent | n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The enzyme activity of hepatitis C virus RNA polymerase (HCVpol) and human rhinovirus 16 RNA polymerase (HRV16pol) is measured as an incorporation of... | Citation and Details BindingDB Entry DOI: 10.7270/Q28P63PG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RNA-directed RNA polymerase (Hepatitis C virus) | BDBM50239939 (CHEMBL4088430) | PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem | Article PubMed | n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen BioPharma, Inc. Curated by ChEMBL | Assay Description Inhibition of HCV NS5B RNA-dependent RNA polymerase activity assessed as reduction in radiolabeled-UTP incorporation into RNA using cIRES template me... | J Med Chem 62: 4555-4570 (2019) Article DOI: 10.1021/acs.jmedchem.9b00143 BindingDB Entry DOI: 10.7270/Q2DB858G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RNA-directed RNA polymerase (Hepatitis C virus) | BDBM50544637 (CHEMBL4635006) | PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | KEGG PC cid PC sid UniChem | Article PubMed | n/a | n/a | 310 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen BioPharma, Inc. Curated by ChEMBL | Assay Description Inhibition of HCV NS5B RNA-dependent RNA polymerase activity assessed as reduction in radiolabeled ribonucleotide monophosphates incorporation into R... | J Med Chem 63: 10380-10395 (2020) Article DOI: 10.1021/acs.jmedchem.0c00935 BindingDB Entry DOI: 10.7270/Q2TM7FP8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RNA-directed RNA polymerase (Hepatitis C virus) | BDBM50274117 (CHEMBL4127921) | PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 330 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen BioPharma, Inc. Curated by ChEMBL | Assay Description Inhibition of HCV NS5B RNA-dependent RNA polymerase activity assessed as reduction in radiolabeled-UTP incorporation into RNA using cIRES template me... | J Med Chem 62: 4555-4570 (2019) Article DOI: 10.1021/acs.jmedchem.9b00143 BindingDB Entry DOI: 10.7270/Q2DB858G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RNA-directed RNA polymerase (Hepatitis C virus) | BDBM50524194 (CHEMBL4454742) | PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | KEGG PC cid PC sid UniChem | Article PubMed | n/a | n/a | 340 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen BioPharma, Inc. Curated by ChEMBL | Assay Description Inhibition of HCV NS5B RNA-dependent RNA polymerase activity assessed as reduction in radiolabeled-UTP incorporation into RNA using cIRES template me... | J Med Chem 62: 4555-4570 (2019) Article DOI: 10.1021/acs.jmedchem.9b00143 BindingDB Entry DOI: 10.7270/Q2DB858G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein (Hepatitis C virus (HCV genotype 1a, isolate H)) | BDBM521555 (((2S,3S,4R,5R)-5-(4-Aminopyrrolo[2,1-f][1,2,4]tria...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | KEGG PC cid PC sid UniChem | US Patent | n/a | n/a | 400 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The enzyme activity of hepatitis C virus RNA polymerase (HCVpol) and human rhinovirus 16 RNA polymerase (HRV16pol) is measured as an incorporation of... | Citation and Details BindingDB Entry DOI: 10.7270/Q28P63PG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RNA-directed RNA polymerase (Hepatitis C virus) | BDBM50544632 (CHEMBL3422648) | PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | KEGG PC cid PC sid UniChem | Article PubMed | n/a | n/a | 420 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen BioPharma, Inc. Curated by ChEMBL | Assay Description Inhibition of HCV NS5B RNA-dependent RNA polymerase activity assessed as reduction in radiolabeled ribonucleotide monophosphates incorporation into R... | J Med Chem 63: 10380-10395 (2020) Article DOI: 10.1021/acs.jmedchem.0c00935 BindingDB Entry DOI: 10.7270/Q2TM7FP8 | |||||||||||
More data for this Ligand-Target Pair |
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