BDBM50370476 Combivir::ZIDOVUDINE TRIPHOSPHATE
SMILES: Cc1cn([C@H]2C[C@H](N=[N+]=[N-])[C@@H](CO[P@@](O)(=O)O[P@@](O)(=O)OP(O)(O)=O)O2)c(=O)[nH]c1=O
InChI Key: InChIKey=GLWHPRRGGYLLRV-XLPZGREQSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Reverse transcriptase (Human immunodeficiency virus 1) | BDBM50370476 (Combivir | ZIDOVUDINE TRIPHOSPHATE) | PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | 41 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
McGill University Curated by ChEMBL | Assay Description Inhibition of HIV1 reverse transcriptase by steady state nucleotide incorporation assay | Antimicrob Agents Chemother 51: 2911-9 (2007) Article DOI: 10.1128/aac.00314-07 BindingDB Entry DOI: 10.7270/Q2CV4MJS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Reverse Transcriptase (Human immunodeficiency virus 1) | BDBM50370476 (Combivir | ZIDOVUDINE TRIPHOSPHATE) | PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | 47 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
McGill University Curated by ChEMBL | Assay Description Inhibition of HIV1 reverse transcriptase M41L/D67N/L210W/T215Y mutant by steady state nucleotide incorporation assay | Antimicrob Agents Chemother 51: 2911-9 (2007) Article DOI: 10.1128/aac.00314-07 BindingDB Entry DOI: 10.7270/Q2CV4MJS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Human immunodeficiency virus type 1 reverse transcriptase (Human immunodeficiency virus 1) | BDBM50370476 (Combivir | ZIDOVUDINE TRIPHOSPHATE) | PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | KEGG PC cid PC sid PDB UniChem Similars | PDB Article PubMed | 91 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Biota, Inc. Curated by ChEMBL | Assay Description Inhibitory constant against HIV-1 reverse transcriptase | J Med Chem 48: 2695-700 (2005) Article DOI: 10.1021/jm040101y BindingDB Entry DOI: 10.7270/Q2G73FG5 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
DNA polymerase delta subunit 1 (Homo sapiens (Human)) | BDBM50370476 (Combivir | ZIDOVUDINE TRIPHOSPHATE) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 2.30E+3 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Pharmacia Corporation Curated by ChEMBL | Assay Description Inhibition of human delta DNA polymerase (95 uL) activity in a solution containg 6.4 mM HEPES (pH 7.5) upon incubation for 12 minutes at 26 degrees C... | J Med Chem 48: 5794-804 (2005) Article DOI: 10.1021/jm050162b BindingDB Entry DOI: 10.7270/Q2G44R39 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA polymerase (Varicella-zoster virus (strain Dumas) (HHV-3) (Hum...) | BDBM50370476 (Combivir | ZIDOVUDINE TRIPHOSPHATE) | UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 5.80E+3 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Pharmacia Corporation Curated by ChEMBL | Assay Description Inhibition of Varicella-Zoster virus DNA polymerase (95 uL) activity in a solution containing 6.4 mM HEPES (pH 7.5), incubation for 12 minutes at 26 ... | J Med Chem 48: 5794-804 (2005) Article DOI: 10.1021/jm050162b BindingDB Entry DOI: 10.7270/Q2G44R39 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA polymerase (Varicella-zoster virus (strain Dumas) (HHV-3) (Hum...) | BDBM50370476 (Combivir | ZIDOVUDINE TRIPHOSPHATE) | UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 1.20E+4 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Pharmacia Corporation Curated by ChEMBL | Assay Description Inhibition of Varicella-Zoster virus DNA polymerase (95 uL) activity in a solution containing 6.4 mM HEPES (pH 7.5), incubation for 12 minutes at 26 ... | J Med Chem 48: 5794-804 (2005) Article DOI: 10.1021/jm050162b BindingDB Entry DOI: 10.7270/Q2G44R39 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Human immunodeficiency virus type 1 reverse transcriptase (Human immunodeficiency virus 1) | BDBM50370476 (Combivir | ZIDOVUDINE TRIPHOSPHATE) | PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | KEGG PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 2.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£t Konstanz Curated by ChEMBL | Assay Description Inhibitory concentration against human immunodeficiency virus type 1 reverse transcriptase | Bioorg Med Chem Lett 15: 869-71 (2005) Article DOI: 10.1016/j.bmcl.2004.12.072 BindingDB Entry DOI: 10.7270/Q2F190GP | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
DNA polymerase (Human cytomegalovirus (HCMV strain AD169) ) | BDBM50370476 (Combivir | ZIDOVUDINE TRIPHOSPHATE) | UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet | KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 2.21E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Inhibition of HCMV DNA polymerase by scintillation proximity assay | Bioorg Med Chem Lett 17: 3349-53 (2007) Article DOI: 10.1016/j.bmcl.2007.03.102 BindingDB Entry DOI: 10.7270/Q2HX1DHN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Human immunodeficiency virus type 1 reverse transcriptase (Human immunodeficiency virus 1) | BDBM50370476 (Combivir | ZIDOVUDINE TRIPHOSPHATE) | PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | KEGG PC cid PC sid PDB UniChem Similars | PDB PubMed | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Polish Academy of Sciences Curated by ChEMBL | Assay Description Tested against HIV-1 reverse transcriptase (HIV-1 RT) with poly(rA)/(dT)12-18 as template and [methyl-3H]-dTTP as competing substrate | J Med Chem 37: 3850-4 (1994) BindingDB Entry DOI: 10.7270/Q2PV6M05 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Human immunodeficiency virus type 1 reverse transcriptase (Human immunodeficiency virus 1) | BDBM50370476 (Combivir | ZIDOVUDINE TRIPHOSPHATE) | PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | KEGG PC cid PC sid PDB UniChem Similars | PDB Article | n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Compound concentration that causes 50 % inhibition of HIV-1 peptide-derived reverse transcriptase (RT) obtained from HIV-1-infected H9 cell cultures | Bioorg Med Chem Lett 1: 357-360 (1991) Article DOI: 10.1016/S0960-894X(01)80472-8 BindingDB Entry DOI: 10.7270/Q2PV6KVZ | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Human immunodeficiency virus type 1 reverse transcriptase (Human immunodeficiency virus 1) | BDBM50370476 (Combivir | ZIDOVUDINE TRIPHOSPHATE) | PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | KEGG PC cid PC sid PDB UniChem Similars | PDB Article | n/a | n/a | 43 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibitory activity against HIV-1 reverse transcriptase | Bioorg Med Chem Lett 5: 2315-2320 (1995) Article DOI: 10.1016/0960-894X(95)00401-E BindingDB Entry DOI: 10.7270/Q2PG1S7P | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
DNA polymerase (alpha/delta/epsilon) (Homo sapiens (Human)) | BDBM50370476 (Combivir | ZIDOVUDINE TRIPHOSPHATE) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 1.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Chulalongkorn University Curated by ChEMBL | Assay Description Inhibition of DNA polymerase alpha | J Nat Prod 59: 839-42 (1997) Article DOI: 10.1021/np960399y BindingDB Entry DOI: 10.7270/Q20C4WPN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA polymerase beta (Homo sapiens (Human)) | BDBM50370476 (Combivir | ZIDOVUDINE TRIPHOSPHATE) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 1.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Chulalongkorn University Curated by ChEMBL | Assay Description Inhibition of DNA polymerase beta | J Nat Prod 59: 839-42 (1997) Article DOI: 10.1021/np960399y BindingDB Entry DOI: 10.7270/Q20C4WPN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA polymerase catalytic subunit (Human herpesvirus 1 (strain KOS) (HHV-1) (Human he...) | BDBM50370476 (Combivir | ZIDOVUDINE TRIPHOSPHATE) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 3.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Inhibition of HSV1 DNA polymerase by scintillation proximity assay | Bioorg Med Chem Lett 18: 3856-9 (2008) Article DOI: 10.1016/j.bmcl.2008.06.060 BindingDB Entry DOI: 10.7270/Q2RB75HB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Reverse transcriptase (Human immunodeficiency virus 1) | BDBM50370476 (Combivir | ZIDOVUDINE TRIPHOSPHATE) | PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a |
University of Pittsburgh School of Medicine Curated by ChEMBL | Assay Description Binding affinity to HIV1 reverse transcriptase | Antimicrob Agents Chemother 53: 3715-9 (2009) Article DOI: 10.1128/aac.00392-09 BindingDB Entry DOI: 10.7270/Q2KD21R2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Reverse transcriptase (Human immunodeficiency virus 1) | BDBM50370476 (Combivir | ZIDOVUDINE TRIPHOSPHATE) | PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | n/a | 1.99E+3 | n/a | n/a | n/a | n/a | n/a |
University of Pittsburgh School of Medicine Curated by ChEMBL | Assay Description Binding affinity to wild type HIV1 LAI reverse transcriptase | Antimicrob Agents Chemother 52: 157-63 (2008) Article DOI: 10.1128/aac.00904-07 BindingDB Entry DOI: 10.7270/Q2CV4MK7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Reverse Transcriptase (Human immunodeficiency virus 1) | BDBM50370476 (Combivir | ZIDOVUDINE TRIPHOSPHATE) | PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | n/a | 1.15E+3 | n/a | n/a | n/a | n/a | n/a |
University of Pittsburgh School of Medicine Curated by ChEMBL | Assay Description Binding affinity to HIV1 LAI reverse transcriptase M41L/L210W/T215Y mutant | Antimicrob Agents Chemother 52: 157-63 (2008) Article DOI: 10.1128/aac.00904-07 BindingDB Entry DOI: 10.7270/Q2CV4MK7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Reverse Transcriptase (Human immunodeficiency virus 1) | BDBM50370476 (Combivir | ZIDOVUDINE TRIPHOSPHATE) | PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | n/a | 3.50E+3 | n/a | n/a | n/a | n/a | n/a |
University of Pittsburgh School of Medicine Curated by ChEMBL | Assay Description Binding affinity to HIV1 LAI reverse transcriptase M41L/L210W/T215Y/M184V mutant | Antimicrob Agents Chemother 52: 157-63 (2008) Article DOI: 10.1128/aac.00904-07 BindingDB Entry DOI: 10.7270/Q2CV4MK7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Reverse Transcriptase (Human immunodeficiency virus 1) | BDBM50370476 (Combivir | ZIDOVUDINE TRIPHOSPHATE) | PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | n/a | 2.90E+3 | n/a | n/a | n/a | n/a | n/a |
University of Pittsburgh School of Medicine Curated by ChEMBL | Assay Description Binding affinity to HIV1 LAI reverse transcriptase M184V mutant | Antimicrob Agents Chemother 52: 157-63 (2008) Article DOI: 10.1128/aac.00904-07 BindingDB Entry DOI: 10.7270/Q2CV4MK7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Reverse transcriptase (Human immunodeficiency virus 1) | BDBM50370476 (Combivir | ZIDOVUDINE TRIPHOSPHATE) | PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
Emory University Curated by ChEMBL | Assay Description Inhibition of HIV1 LAI reverse transcriptase wild type in presence of 5 mM ATP by heteropolymeric DNA polymerase assay | Antimicrob Agents Chemother 51: 2078-84 (2007) Article DOI: 10.1128/aac.00119-07 BindingDB Entry DOI: 10.7270/Q2H134SQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Reverse transcriptase (Human immunodeficiency virus 1) | BDBM50370476 (Combivir | ZIDOVUDINE TRIPHOSPHATE) | PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 420 | n/a | n/a | n/a | n/a | n/a | n/a |
Emory University Curated by ChEMBL | Assay Description Inhibition of HIV1 pNL4-3 reverse transcriptase wild type pNL4-3 in presence of 5 mM ATP by heteropolymeric DNA polymerase assay | Antimicrob Agents Chemother 51: 2078-84 (2007) Article DOI: 10.1128/aac.00119-07 BindingDB Entry DOI: 10.7270/Q2H134SQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Reverse transcriptase (Human immunodeficiency virus 1) | BDBM50370476 (Combivir | ZIDOVUDINE TRIPHOSPHATE) | PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a | n/a |
Emory University Curated by ChEMBL | Assay Description Inhibition of HIV1 LAI reverse transcriptase wild type LAI by heteropolymeric DNA polymerase assay | Antimicrob Agents Chemother 51: 2078-84 (2007) Article DOI: 10.1128/aac.00119-07 BindingDB Entry DOI: 10.7270/Q2H134SQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Reverse transcriptase (Human immunodeficiency virus 1) | BDBM50370476 (Combivir | ZIDOVUDINE TRIPHOSPHATE) | PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
Emory University Curated by ChEMBL | Assay Description Inhibition of HIV1 pNL4-3 reverse transcriptase wild type pNL4-3 by heteropolymeric DNA polymerase assay | Antimicrob Agents Chemother 51: 2078-84 (2007) Article DOI: 10.1128/aac.00119-07 BindingDB Entry DOI: 10.7270/Q2H134SQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Reverse Transcriptase (Human immunodeficiency virus 1) | BDBM50370476 (Combivir | ZIDOVUDINE TRIPHOSPHATE) | PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | n/a | >6.00E+4 | n/a | n/a | n/a | n/a | n/a |
Veterans Affairs Medical Center Curated by ChEMBL | Assay Description Binding affinity to HIV1 reverse transcriptase M184V mutant assessed as L-3'-azido-NTP incorporation in nascent DNA | Eur J Med Chem 46: 3832-44 (2011) Article DOI: 10.1016/j.ejmech.2011.05.051 BindingDB Entry DOI: 10.7270/Q2RN3BQP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Reverse transcriptase (Human immunodeficiency virus 1) | BDBM50370476 (Combivir | ZIDOVUDINE TRIPHOSPHATE) | PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | n/a | 5.50E+4 | n/a | n/a | n/a | n/a | n/a |
Veterans Affairs Medical Center Curated by ChEMBL | Assay Description Binding affinity to HIV1 reverse transcriptase assessed as L-3'-azido-NTP incorporation in nascent DNA | Eur J Med Chem 46: 3832-44 (2011) Article DOI: 10.1016/j.ejmech.2011.05.051 BindingDB Entry DOI: 10.7270/Q2RN3BQP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Reverse transcriptase (Human immunodeficiency virus 1) | BDBM50370476 (Combivir | ZIDOVUDINE TRIPHOSPHATE) | PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 54 | n/a | n/a | n/a | n/a | n/a | n/a |
Kagoshima University Curated by ChEMBL | Assay Description Inhibition of HIV1 recombinant reverse transcriptase | Antimicrob Agents Chemother 51: 2600-4 (2007) Article DOI: 10.1128/aac.00212-07 BindingDB Entry DOI: 10.7270/Q2XW4NKZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Reverse transcriptase (Human immunodeficiency virus 1) | BDBM50370476 (Combivir | ZIDOVUDINE TRIPHOSPHATE) | PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 320 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Inhibition of HIV1 RT mediated DNA-dependent DNA synthesis initiation using RNA PPT primed substrate by scintillation proximity assay | J Biol Chem 282: 8005-10 (2007) Article DOI: 10.1074/jbc.m608274200 BindingDB Entry DOI: 10.7270/Q2PG1VH3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Reverse transcriptase (Human immunodeficiency virus 1) | BDBM50370476 (Combivir | ZIDOVUDINE TRIPHOSPHATE) | PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 360 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Inhibition of HIV1 RT mediated DNA-dependent DNA synthesis initiation using RNA/DNAM duplex primed substrate by scintillation proximity assay | J Biol Chem 282: 8005-10 (2007) Article DOI: 10.1074/jbc.m608274200 BindingDB Entry DOI: 10.7270/Q2PG1VH3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Human herpesvirus 1 DNA polymerase (Human herpesvirus 1 (strain 17) (HHV-1) (Human her...) | BDBM50370476 (Combivir | ZIDOVUDINE TRIPHOSPHATE) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 3.30E+3 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Pharmacia Corporation Curated by ChEMBL | Assay Description Inhibition of herpes simplex virus type 1 DNA polymerase (95 uL) activity in a solution containing 6.4 mM HEPES (pH 7.5), incubation for 12 minutes a... | J Med Chem 48: 5794-804 (2005) Article DOI: 10.1021/jm050162b BindingDB Entry DOI: 10.7270/Q2G44R39 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Reverse transcriptase (Human immunodeficiency virus 1) | BDBM50370476 (Combivir | ZIDOVUDINE TRIPHOSPHATE) | PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 7.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Saarland University Curated by ChEMBL | Assay Description Inhibition of HIV1 reverse transcriptase using T19-Cy5 labeled 23-mer DNA/T2-TAMRA labeled 63-mer DNA as primer/template assessed as inhibition of dN... | J Med Chem 59: 7212-22 (2016) Article DOI: 10.1021/acs.jmedchem.6b00730 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA polymerase alpha subunit (Homo sapiens (Human)) | BDBM50370476 (Combivir | ZIDOVUDINE TRIPHOSPHATE) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 1.34E+4 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Pharmacia Corporation Curated by ChEMBL | Assay Description Inhibition of human alpha DNA polymerase (95 uL) activity in a solution containg 6.4 mM HEPES (pH 7.5) upon incubation for 12 minutes at 26 degrees C... | J Med Chem 48: 5794-804 (2005) Article DOI: 10.1021/jm050162b BindingDB Entry DOI: 10.7270/Q2G44R39 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA polymerase (Human cytomegalovirus (HCMV strain AD169) ) | BDBM50370476 (Combivir | ZIDOVUDINE TRIPHOSPHATE) | UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet | KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 2.21E+4 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Pharmacia Corporation Curated by ChEMBL | Assay Description Inhibition of human cytomegalovirus DNA polymerase (95 uL) activity in a solution containing 6.4 mM HEPES (pH 7.5), incubation for 12 minutes at 26 d... | J Med Chem 48: 5794-804 (2005) Article DOI: 10.1021/jm050162b BindingDB Entry DOI: 10.7270/Q2G44R39 | |||||||||||
More data for this Ligand-Target Pair |