Reaction Details |
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Target | Activin receptor type-1 [172-499] |
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Ligand | BDBM522134 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Luminescence-Based ADPGlo Kinase Activity Assay |
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IC50 | 460±n/a nM |
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Citation | Arista, L; Chamoin, S; D''Alessandro, PL; Lindvall, M; Lizos, D; Stiefl, NJ; Teixeira-Fouchard, S; Ullrich, T; Weiler, S Pyridinone derivatives and their use as selective ALK-2 inhibitors US Patent US11160797 Publication Date 11/2/2021 |
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More Info.: | Get all data from this article, Assay Method |
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Activin receptor type-1 [172-499] |
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Name: | Activin receptor type-1 [172-499] |
Synonyms: | ACVR1 | ACVR1_HUMAN | ACVRLK2 | Activin receptor type-1 (ACVR1) | Activin receptor-like kinase 2 (ALK-2)(aa 172-499) | Activin receptor-like kinase 2 (ALK2)(172-499) |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 37139.64 |
Organism: | Homo sapiens (Human) |
Description: | aa 172-499 |
Residue: | 328 |
Sequence: | TTNVGDSTLADLLDHSCTSGSGSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGEN
VAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSL
YDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCC
IADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVL
WEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLA
KLMKECWYQNPSARLTALRIKKTLTKID
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BDBM522134 |
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n/a |
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Name | BDBM522134 |
Synonyms: | US11160797, Example 42 |
Type | Small organic molecule |
Emp. Form. | C22H22N4O2 |
Mol. Mass. | 374.4357 |
SMILES | CC(C)n1cc(ccc1=O)-c1cc(cnc1N)-c1ccc2N(C)C(=O)Cc2c1 |
Structure |
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