| Reaction Details |
|---|
 | Report a problem with these data |
| Target | TGF-beta receptor type-1 [162-503] |
|---|
| Ligand | BDBM522132 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | In Vitro Enzyme Inhibition Using a Biochemical Peptide Phosphorylation Assay- Caliper Assay |
|---|
| IC50 | 4200±n/a nM |
|---|
| Citation |  Arista, L; Chamoin, S; D''Alessandro, PL; Lindvall, M; Lizos, D; Stiefl, NJ; Teixeira-Fouchard, S; Ullrich, T; Weiler, S Pyridinone derivatives and their use as selective ALK-2 inhibitors US Patent US11160797 Publication Date 11/2/2021 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| TGF-beta receptor type-1 [162-503] |
|---|
| Name: | TGF-beta receptor type-1 [162-503] |
|---|
| Synonyms: | ALK5 | Activin receptor-like kinase 5 (ALK-5)(aa 162-503) | Activin receptor-like kinase 5 (ALK5)(162-503) | SKR4 | TGFBR1 | TGFR1_HUMAN |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 38872.23 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | aa 162-503 |
|---|
| Residue: | 342 |
|---|
| Sequence: | EDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWR
GKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSD
YHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILV
KKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADI
YAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSC
EALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM
|
|
|
|---|
| BDBM522132 |
|---|
| n/a |
|---|
| Name | BDBM522132 |
|---|
| Synonyms: | US11160797, Example 40 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C27H31N3O2 |
|---|
| Mol. Mass. | 429.5539 |
|---|
| SMILES | CCC(CC)CN1C(=O)Cc2cc(ccc12)-c1cncc(c1)-c1ccc(=O)n(c1)C(C)C |
|---|
| Structure | 
|
|---|
Search and Browse
