Reaction Details |
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Target | Serine/threonine-protein kinase receptor R3 [166-493] |
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Ligand | BDBM522135 |
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Substrate/Competitor | n/a |
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Meas. Tech. | In Vitro Enzyme Inhibition Using a Biochemical Peptide Phosphorylation Assay- Caliper Assay |
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IC50 | 520±n/a nM |
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Citation | Arista, L; Chamoin, S; D''Alessandro, PL; Lindvall, M; Lizos, D; Stiefl, NJ; Teixeira-Fouchard, S; Ullrich, T; Weiler, S Pyridinone derivatives and their use as selective ALK-2 inhibitors US Patent US11160797 Publication Date 11/2/2021 |
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More Info.: | Get all data from this article, Assay Method |
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Serine/threonine-protein kinase receptor R3 [166-493] |
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Name: | Serine/threonine-protein kinase receptor R3 [166-493] |
Synonyms: | ACVL1_HUMAN | ACVRL1 | ACVRLK1 | ALK1 | Activin receptor-like kinase 1 (ALK1)(aa 166-493) |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 36974.75 |
Organism: | Homo sapiens (Human) |
Description: | aa 166-493 |
Residue: | 328 |
Sequence: | ASEQGDSMLGDLLDSDCTTGSGSGLPFLVQRTVARQVALVECVGKGRYGEVWRGLWHGES
VAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSL
YDFLQRQTLEPHLALRLAVSAACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCC
IADLGLAVMHSQGSDYLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVL
WEIARRTIVNGIVEDYRPPFYDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLA
QMMRECWYPNPSARLTALRIKKTLQKIS
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BDBM522135 |
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n/a |
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Name | BDBM522135 |
Synonyms: | US11160797, Example 43 |
Type | Small organic molecule |
Emp. Form. | C21H21N5O2 |
Mol. Mass. | 375.4237 |
SMILES | CC(C)n1cc(ccc1=O)-c1nc(cnc1N)-c1ccc2N(C)C(=O)Cc2c1 |
Structure |
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