| Reaction Details |
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 | Report a problem with these data |
| Target | TGF-beta receptor type-1 [162-503] |
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| Ligand | BDBM522135 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In Vitro Enzyme Inhibition Using a Biochemical Peptide Phosphorylation Assay- Caliper Assay |
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| IC50 | 1000±n/a nM |
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| Citation |  Arista, L; Chamoin, S; D''Alessandro, PL; Lindvall, M; Lizos, D; Stiefl, NJ; Teixeira-Fouchard, S; Ullrich, T; Weiler, S Pyridinone derivatives and their use as selective ALK-2 inhibitors US Patent US11160797 Publication Date 11/2/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| TGF-beta receptor type-1 [162-503] |
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| Name: | TGF-beta receptor type-1 [162-503] |
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| Synonyms: | ALK5 | Activin receptor-like kinase 5 (ALK-5)(aa 162-503) | Activin receptor-like kinase 5 (ALK5)(162-503) | SKR4 | TGFBR1 | TGFR1_HUMAN |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 38872.23 |
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| Organism: | Homo sapiens (Human) |
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| Description: | aa 162-503 |
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| Residue: | 342 |
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| Sequence: | EDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWR
GKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSD
YHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILV
KKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADI
YAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSC
EALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM
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| BDBM522135 |
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| n/a |
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| Name | BDBM522135 |
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| Synonyms: | US11160797, Example 43 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H21N5O2 |
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| Mol. Mass. | 375.4237 |
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| SMILES | CC(C)n1cc(ccc1=O)-c1nc(cnc1N)-c1ccc2N(C)C(=O)Cc2c1 |
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| Structure | 
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