| Reaction Details |
|---|
 | Report a problem with these data |
| Target | OTU domain-containing protein 7B |
|---|
| Ligand | BDBM443336 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Biochemical Assay |
|---|
| IC50 | 550±n/a nM |
|---|
| Citation |  Kemp, MI; Stockley, ML; Woodrow, MD; Jones, A Spiro-condensed pyrrolidine derivatives as deubiquitylating enzymes (DUB) inhibitors US Patent US11236092 Publication Date 2/1/2022 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| OTU domain-containing protein 7B |
|---|
| Name: | OTU domain-containing protein 7B |
|---|
| Synonyms: | Cellular zinc finger anti-NF-kappa-B protein | Cezanne | OTU7B_HUMAN | OTUD7B | ZA20D1 | Zinc finger A20 domain-containing protein 1 | Zinc finger protein Cezanne |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 92527.32 |
|---|
| Organism: | Human |
|---|
| Description: | Q6GQQ9 |
|---|
| Residue: | 843 |
|---|
| Sequence: | MTLDMDAVLSDFVRSTGAEPGLARDLLEGKNWDVNAALSDFEQLRQVHAGNLPPSFSEGS
GGSRTPEKGFSDREPTRPPRPILQRQDDIVQEKRLSRGISHASSSIVSLARSHVSSNGGG
GGSNEHPLEMPICAFQLPDLTVYNEDFRSFIERDLIEQSMLVALEQAGRLNWWVSVDPTS
QRLLPLATTGDGNCLLHAASLGMWGFHDRDLMLRKALYALMEKGVEKEALKRRWRWQQTQ
QNKESGLVYTEDEWQKEWNELIKLASSEPRMHLGTNGANCGGVESSEEPVYESLEEFHVF
VLAHVLRRPIVVVADTMLRDSGGEAFAPIPFGGIYLPLEVPASQCHRSPLVLAYDQAHFS
ALVSMEQKENTKEQAVIPLTDSEYKLLPLHFAVDPGKGWEWGKDDSDNVRLASVILSLEV
KLHLLHSYMNVKWIPLSSDAQAPLAQPESPTASAGDEPRSTPESGDSDKESVGSSSTSNE
GGRRKEKSKRDREKDKKRADSVANKLGSFGKTLGSKLKKNMGGLMHSKGSKPGGVGTGLG
GSSGTETLEKKKKNSLKSWKGGKEEAAGDGPVSEKPPAESVGNGGSKYSQEVMQSLSILR
TAMQGEGKFIFVGTLKMGHRHQYQEEMIQRYLSDAEERFLAEQKQKEAERKIMNGGIGGG
PPPAKKPEPDAREEQPTGPPAESRAMAFSTGYPGDFTIPRPSGGGVHCQEPRRQLAGGPC
VGGLPPYATFPRQCPPGRPYPHQDSIPSLEPGSHSKDGLHRGALLPPPYRVADSYSNGYR
EPPEPDGWAGGLRGLPPTQTKCKQPNCSFYGHPETNNFCSCCYREELRRREREPDGELLV
HRF
|
|
|
|---|
| BDBM443336 |
|---|
| n/a |
|---|
| Name | BDBM443336 |
|---|
| Synonyms: | N-(3-(1-Cyano-2'-oxo-1',4'-dihydro- 2'H-spiro[pyrrolidine-3,3'-quinolin]- 6'-yl)phenyl)cyclopropanesulfonamide | US10654853, Example 109 | US11236092, Example 109 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H22N4O3S |
|---|
| Mol. Mass. | 422.5 |
|---|
| SMILES | O=C1Nc2ccc(cc2CC11CCN(C1)C#N)-c1cccc(NS(=O)(=O)C2CC2)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
