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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase JAK1 | ||
| Ligand | BDBM305831 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | JAK Caliper Enzyme Assay at 1 mM ATP | ||
| IC50 | 174±n/a nM | ||
| Citation |  Brown, MF; Dermenci, A; Fensome, A; Gerstenberger, BS; Hayward, MM; Owen, DR; Wright, SW; Xing, LH; Yang, X Pyrazolo[1,5-A]PYRAZIN-4-YL derivatives US Patent US10144738 Publication Date 12/4/2018 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase JAK1 | |||
| Name: | Tyrosine-protein kinase JAK1 | ||
| Synonyms: | JAK-1 | JAK1 | JAK1A | JAK1B | JAK1_HUMAN | Janus kinase 1 | Janus kinase 1 (JAK1) | Janus kinase 1 JAK1 | ||
| Type: | Protein | ||
| Mol. Mass.: | 133293.73 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P23458 | ||
| Residue: | 1154 | ||
| Sequence: |
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| BDBM305831 | |||
| n/a | |||
| Name | BDBM305831 | ||
| Synonyms: | 2-((1r,3s)-1-(4-(6-(3-Amino-1H-pyrazol-5-yl)pyrazolo[1,5-a]pyrazin-4-yl)-1H-pyrazol-1-yl)-3-methoxycyclobutyl)acetonitrile | US10144738, Example 30 | US10822341, Example 30 | US11472809, Example 30 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C19H19N9O | ||
| Mol. Mass. | 389.4139 | ||
| SMILES | CO[C@H]1C[C@@](CC#N)(C1)n1cc(cn1)-c1nc(cn2nccc12)-c1cc(N)[nH]n1 |r,wU:4.9,wD:2.1,(-.8,7.41,;-2.13,6.64,;-2.13,5.1,;-3.22,4.01,;-2.13,2.93,;-2.9,1.59,;-4.44,1.59,;-5.98,1.59,;-1.04,4.01,;-1.36,1.59,;-1.84,.13,;-.59,-.78,;.65,.13,;.18,1.59,;-.59,-2.32,;.74,-3.09,;.74,-4.63,;-.59,-5.4,;-1.93,-4.63,;-3.39,-5.1,;-4.3,-3.86,;-3.39,-2.61,;-1.93,-3.09,;2.07,-5.4,;3.54,-4.92,;4.44,-6.17,;5.98,-6.17,;3.54,-7.41,;2.07,-6.94,)| | ||
| Structure | 
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