Reaction Details |
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Target | Polymerase basic protein 2 |
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Ligand | BDBM552316 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Influenza Antiviral Assay |
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EC50 | 1.40±n/a nM |
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Citation | Hendricks, RT; Stoycheva, AD; Bonfanti, J; Raboisson, PJ; Fortin, JM; Mercey, GJ Macrocyclic flu endonuclease inhibitors US Patent US11312727 Publication Date 4/26/2022 |
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More Info.: | Get all data from this article, Assay Method |
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Polymerase basic protein 2 |
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Name: | Polymerase basic protein 2 |
Synonyms: | B4URF7_I33A0 | PB2 | RNA-directed RNA polymerase subunit P3 |
Type: | Protein |
Mol. Mass.: | 85824.43 |
Organism: | Influenza A virus (strain A/WS/1933 H1N1) |
Description: | B4URF7 |
Residue: | 759 |
Sequence: | MERIKELRNLMSQSRTREILTKTTVDHMAIIKKYTSGRQEKNPALRMKWMMAMKYPITAD
KRITEMIPERNEQGQTLWSKMNDAGSDRVMVSPLAVTWWNRNGPVTSTVHYPKIYKTYFE
KVERLKHGTFGPVHFRNQVKIRRRVDINPGHADLSAKEAQDVIMEVVFPNEVGARILTSE
SQLTTTKEKKEELQGCKISPLMVAYMLERELVRKTRFLPVAGGTSSVYIEVLHLTQGTCW
EQMYTPGGEARNDDVDQSLIIAARNIVRRATVSADPLASLLEMCHSTQIGGVRMVNILRQ
NPTEEQAVDICKAAMGLRISSSFSFGGFTFKRTSGSSVKREEEVLTGNLQTLKIRVHEGY
EEFTMVGRRATAILRKATRRLIQLIVSGRDEQSIAEAIIVAMVFSQEDCMIKAVRGDLNF
VNRANQRLNPMHQLLRHFQKDAKVLFQNWGIESIDNVMGMIGILPDMTPSTEMSMRGVRI
SKMGVDEYSSAEKIVVSIDRFLRVRDQRGNVLLSPEEVSETQGTEKLTITYSSSMMWEIN
GPESVLVNTYQWIIRNWETVKIQWSQNPTMLYNKMEFEPFQSLVPKAVRGQYSGFVRTLF
QQMRDVLGTFDTAQIIKLLPFAAAPPKQSGMQFSSLTINVRGSGMRILVRGNSPVFNYNK
TTKRLTVLGKDAGPLTEDPDEGTAGVESAVLRGFLILGKEDRRYGPALSINELSNLAKGE
KANVLIGQGDVVLVMKRKRNSSILTDSQTATKRIRMAIN
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BDBM552316 |
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n/a |
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Name | BDBM552316 |
Synonyms: | (1a*S,11b*S,20a*S)-22,23-difluoro-17-hydroxy-1a,2,6,11b,20,20a-hexahydro-1H-5,4-(epiprop[1]en[1]yl[3]ylidene)-12,19-methanobenzo[6,7]thiepino[4,5-c]cyclopropa[k]pyrido[1,2-f][1]oxa[5,6,9]triazacyclotridecine-16,18-dione (Compound 127AA) | US11312727, Compound 127BA |
Type | Small organic molecule |
Emp. Form. | C26H21F2N3O4S |
Mol. Mass. | 509.524 |
SMILES | Oc1c2C(=O)N3CN([C@@H]4c5ccccc5SCc5c(F)c(F)cc(OC[C@H]6C[C@@H]6C3)c45)n2ccc1=O |r| |
Structure |
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