| Reaction Details |
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 | Report a problem with these data |
| Target | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] |
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| Ligand | BDBM556284 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Biochemical Assay |
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| IC50 | 19.5±n/a nM |
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| Citation |  Rai, R; Booth, R; Green, MJ PGDH inhibitors and methods of making and using US Patent US11345702 Publication Date 5/31/2022 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] |
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| Name: | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] |
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| Synonyms: | 15-PGDH | 15-hydroxyprostaglandin dehydrogenase [NAD+] | HPGD | PGDH1 | PGDH_HUMAN | Prostaglandin dehydrogenase 1 (15-PGDH) | SDR36C1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 28974.46 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P15428 |
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| Residue: | 266 |
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| Sequence: | MHVNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLF
IQCDVADQQQLRDTFRKVVDHFGRLDILVNNAGVNNEKNWEKTLQINLVSVISGTYLGLD
YMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAALAANLMNSGVRLNA
ICPGFVNTAILESIEKEENMGQYIEYKDHIKDMIKYYGILDPPLIANGLITLIEDDALNG
AIMKITTSKGIHFQDYDTTPFQAKTQ
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| BDBM556284 |
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| n/a |
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| Name | BDBM556284 |
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| Synonyms: | US11345702, Table 1.2 | US20230390274, Compound A-64 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H19FN4O2 |
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| Mol. Mass. | 354.3782 |
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| SMILES | COc1ccc(cc1)-n1cnc2cc(cnc12)C(=O)N1CCC(F)CC1 |
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| Structure | 
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