| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cyclin-dependent kinase 5 |
|---|
| Ligand | BDBM50110183 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | CDK5 Inhibition Assay |
|---|
| IC50 | 192±n/a nM |
|---|
| Citation |  Song, Y; Chen, X Substituted pyrimidines as CDK4/6 inhibitors US Patent US11351170 Publication Date 6/7/2022 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cyclin-dependent kinase 5 |
|---|
| Name: | Cyclin-dependent kinase 5 |
|---|
| Synonyms: | CDK5 | CDK5_HUMAN | CDKN5 | Cell division protein kinase 5 | Cyclin-dependent kinase 5 (CDK5/ p25) | Cyclin-dependent kinase 5 (CDK5/p35) | Cyclin-dependent-like kinase 5 | Cyclin-dependent-like kinase 5 (CDK5) | PSSALRE | Serine/threonine-protein kinase PSSALRE | Tau protein kinase II catalytic subunit |
|---|
| Type: | Enzyme Subunit |
|---|
| Mol. Mass.: | 33308.61 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 292 |
|---|
| Sequence: | MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH
KNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSR
NVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYS
TSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYP
MYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP
|
|
|
|---|
| BDBM50110183 |
|---|
| n/a |
|---|
| Name | BDBM50110183 |
|---|
| Synonyms: | Abemaciclib | LY-2835219 | US10626107, Example LY2835219 | US10662186, Compound LY2835219 | US10696678, Example LY2835219 | US10988476, Compound LY2835219 | US11053238, LY2835219 | US11091476, Example LY2835219 | US11351170, Example Abemaciclib |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C27H32F2N8 |
|---|
| Mol. Mass. | 506.5934 |
|---|
| SMILES | CCN1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C(C)C)c4c3)nc2)CC1 |
|---|
| Structure | 
|
|---|
Search and Browse
