Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI
LigandBDBM8720
Substrate/CompetitorCrotonoyl-ACP
Meas. Tech.Enzyme Inhibition Assay
pH6.5±n/a
Temperature303.15±n/a K
IC50 2400±1200 nM
Citation Seefeld, MA; Miller, WH; Newlander, KA; Burgess, WJ; DeWolf, WE; Elkins, PA; Head, MS; Jakas, DR; Janson, CA; Keller, PM; Manley, PJ; Moore, TD; Payne, DJ; Pearson, S; Polizzi, BJ; Qiu, X; Rittenhouse, SF; Uzinskas, IN; Wallis, NG; Huffman, WF Indole naphthyridinones as inhibitors of bacterial enoyl-ACP reductases FabI and FabK. J Med Chem46:1627-35 (2003) [PubMed]  Article
More Info.:Get all data from this article,  Inhibition_Run data,   Solution Info,  Assay Method
 
Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI
Name:Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI
Synonyms:Enoyl-ACP Reductase (FabI) | Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI | FABI_STAAR | NADPH-dependent enoyl-ACP reductase | fabI | trans-2-enoyl-[acyl carrier protein] reductase
Type:Enzyme
Mol. Mass.:27989.00
Organism:Staphylococcus aureus
Description:Q6GI75
Residue:256
Sequence:
MLNLENKTYVIMGIANKRSIAFGVAKVLDQLGAKLVFTYRKERSRKELEKLLEQLNQPEA
HLYQIDVQSDEEVINGFEQIGKDVGNIDGVYHSIAFANMEDLRGRFSETSREGFLLAQDI
SSYSLTIVAHEAKKLMPEGGSIVATTYLGGEFAVQNYNVMGVAKASLEANVKYLALDLGP
DNIRVNAISAGPIRTLSAKGVGGFNTILKEIEERAPLKRNVDQVEVGKTAAYLLSDLSSG
VTGENIHVDSGFHAIK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM8720
Crotonoyl-ACP
Name:Crotonoyl-ACP
Synonyms:n/a
Type:Other Protein Type
Mol. Mass.:358.43
Organism:n/a
Description:1. NAD(P)H is its co-substrate. 2. Crotonoyl-ACP was synthesized using ACP synthase to catalyse the addition of a crotonoyl group from crotonoyl-CoA to apo-ACP
Residue:3
Sequence:
n/a