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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Histone-lysine N-methyltransferase EZH2 | ||
| Ligand | BDBM574859 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ZH2 biochemical assay (IC50) | ||
| IC50 | 0.5±n/a nM | ||
| Citation |  Brenneman, JB; Côté, A; Gehling, VS; Khanna, A; Levell, JR; Moine, L Modulators of methyl modifying enzymes, compositions and uses thereof US Patent US11459315 Publication Date 10/4/2022 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Histone-lysine N-methyltransferase EZH2 | |||
| Name: | Histone-lysine N-methyltransferase EZH2 | ||
| Synonyms: | ENX-1 | EZH2 | EZH2_HUMAN | Enhancer of zeste homolog 2 (EZH2) | Histone-lysine N-methyltransferase EZH2 | KMT6 | Lysine N-methyltransferase 6 | ||
| Type: | Protein | ||
| Mol. Mass.: | 85367.84 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q15910 | ||
| Residue: | 746 | ||
| Sequence: |
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| BDBM574859 | |||
| n/a | |||
| Name | BDBM574859 | ||
| Synonyms: | US11459315, Example 18 (isomer 1) | ||
| Type | Small organic molecule | ||
| Emp. Form. | C27H35N3O3S | ||
| Mol. Mass. | 481.65 | ||
| SMILES | COC1CC[C@@H](CC1)[C@@H](C)n1c(C)c(C(=O)NCc2c(SC)cc(C)[nH]c2=O)c2ccccc12 |r,wD:5.8,8.9,(9.28,-3.6,;7.71,-3.86,;6.76,-2.5,;5.29,-2.69,;4.38,-1.48,;4.97,-.06,;6.5,.13,;7.38,-1.12,;4.02,1.19,;4.67,2.61,;2.52,.97,;1.46,2.17,;1.82,3.74,;.11,1.59,;-1.28,2.32,;-1.28,3.82,;-2.6,1.51,;-3.95,2.32,;-5.26,1.55,;-5.29,.02,;-3.94,-.82,;-3.94,-2.36,;-6.5,-.71,;-7.96,.02,;-9.28,-.71,;-7.97,1.51,;-6.65,2.32,;-6.65,3.86,;.25,-.02,;-.73,-1.08,;-.3,-2.58,;1.24,-2.87,;2.19,-1.81,;1.71,-.31,)| | ||
| Structure | 
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