| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Ataxin-1 |
|---|
| Ligand | BDBM579850 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Biochemical ATX Assa |
|---|
| IC50 | 2.40±n/a nM |
|---|
| Citation |  Kuttruff, CA; Bretschneider, T; Godbout, C; Koolman, HF; Martyres, D; Roth, GJ N-methyl, n-(6-(methoxy)pyridazin-3-yl) amine derivatives as autotaxin (ATX) modulators US Patent US11485727 Publication Date 11/1/2022 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Ataxin-1 |
|---|
| Name: | Ataxin-1 |
|---|
| Synonyms: | ATX1 | ATX1_HUMAN | ATXN1 | SCA1 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 86941.25 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P54253 |
|---|
| Residue: | 815 |
|---|
| Sequence: | MKSNQERSNECLPPKKREIPATSRSSEEKAPTLPSDNHRVEGTAWLPGNPGGRGHGGGRH
GPAGTSVELGLQQGIGLHKALSTGLDYSPPSAPRSVPVATTLPAAYATPQPGTPVSPVQY
AHLPHTFQFIGSSQYSGTYASFIPSQLIPPTANPVTSAVASAAGATTPSQRSQLEAYSTL
LANMGSLSQTPGHKAEQQQQQQQQQQQQHQHQQQQQQQQQQQQQQHLSRAPGLITPGSPP
PAQQNQYVHISSSPQNTGRTASPPAIPVHLHPHQTMIPHTLTLGPPSQVVMQYADSGSHF
VPREATKKAESSRLQQAIQAKEVLNGEMEKSRRYGAPSSADLGLGKAGGKSVPHPYESRH
VVVHPSPSDYSSRDPSGVRASVMVLPNSNTPAADLEVQQATHREASPSTLNDKSGLHLGK
PGHRSYALSPHTVIQTTHSASEPLPVGLPATAFYAGTQPPVIGYLSGQQQAITYAGSLPQ
HLVIPGTQPLLIPVGSTDMEASGAAPAIVTSSPQFAAVPHTFVTTALPKSENFNPEALVT
QAAYPAMVQAQIHLPVVQSVASPAAAPPTLPPYFMKGSIIQLANGELKKVEDLKTEDFIQ
SAEISNDLKIDSSTVERIEDSHSPGVAVIQFAVGEHRAQVSVEVLVEYPFFVFGQGWSSC
CPERTSQLFDLPCSKLSVGDVCISLTLKNLKNGSVKKGQPVDPASVLLKHSKADGLAGSR
HRYAEQENGINQGSAQMLSENGELKFPEKMGLPAAPFLTKIEPSKPAATRKRRWSAPESR
KLEKSEDEPPLTLPKPSLIPQEVKICIEGRSNVGK
|
|
|
|---|
| BDBM579850 |
|---|
| n/a |
|---|
| Name | BDBM579850 |
|---|
| Synonyms: | US11485727, Example 2.21 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C25H24F4N6O2 |
|---|
| Mol. Mass. | 516.4907 |
|---|
| SMILES | CC(=O)N1CC2(C1)CN(C2)c1ccc(CNc2ccc(OCc3ccc(nc3)C(F)(F)F)nn2)c(F)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
