Ki Summary

Reaction Details

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Target

Apelin receptor

Ligand

BDBM310305

Substrate/Competitor

n/a

Meas. Tech.

[35S]GTPgammaS Binding

EC50

5.20±n/a nM

Citation

Chen, X; Cheng, AC; Connors, RV; Debenedetto, MV; Dransfield, PJ; Fu, Z; Harvey, JS; Heath, JA; Houze, J; Judd, TC; Kopecky, DJ; Lai, S; Ma, Z; Nishimura, N; Olson, SH; Pattaropong, V; Wang, X Compounds for use in preparing heterocyclic triazole agonists of the APJ receptor US Patent US10150760 Publication Date 12/11/2018

More Info.:

Get all data from this article, Assay Method

Apelin receptor

Name:

Apelin receptor

Synonyms:

Type:

Enzyme Catalytic Domain

Mol. Mass.:

42664.06

Organism:

Homo sapiens (Human)

Description:

P35414

Residue:

380

Sequence:

MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREK
RRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCL
TGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQ
CYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGL
RKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYV
NSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGK
GGEQMHEKSIPYSQETLVVD

BDBM310305

n/a

Name

BDBM310305

Synonyms:

US10150760, Example 101.0 | US10150760, Example 102.0

Type

Small organic molecule

Emp. Form.

C21H27ClN8O5S

Mol. Mass.

539.008

SMILES

COc1ncnc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(Cl)cn2)nnc1[C@H]1CCCOC1 |r,wU:16.17,18.19,wD:30.32,(-7.1,1.22,;-5.77,.45,;-4.44,1.22,;-4.44,2.76,;-3.1,3.53,;-1.77,2.76,;-1.77,1.22,;-.44,.45,;.9,1.22,;-3.1,.45,;-3.1,-1.09,;-1.86,-1.99,;-.52,-1.22,;.81,-1.99,;.04,-3.33,;1.58,-3.33,;2.14,-1.22,;2.14,.32,;3.48,-1.99,;3.48,-3.53,;4.81,-1.22,;6.14,-1.99,;7.48,-1.22,;7.48,.32,;8.81,1.09,;6.14,1.09,;4.81,.32,;-2.33,-3.46,;-3.87,-3.46,;-4.35,-1.99,;-5.84,-1.59,;-6.24,-.11,;-7.72,.29,;-8.81,-.8,;-8.41,-2.28,;-6.93,-2.68,)|

Structure