Reaction Details |
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Target | Coagulation factor XI |
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Ligand | BDBM617854 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Factor XIa Assay |
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IC50 | 1633±n/a nM |
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Citation | Jabri, S; Ogawa, AK; Sinz, CJ; Hicks, JD; Cheng, AC; Gao, Y; Yang, S; Bao, J; Hayes, DA; Lang, SB; Taoka, BM; Tian, M; Shearn-Nance, GP; Kuang, R; Lombardo, MJ; Wu, Z; Zhao, Z PLASMA KALLIKREIN INHIBITORS US Patent US20230286958 Publication Date 9/14/2023 |
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More Info.: | Get all data from this article, Assay Method |
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Coagulation factor XI |
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Name: | Coagulation factor XI |
Synonyms: | Coagulation factor XIa | Coagulation factor XIa heavy chain | Coagulation factor XIa light chain | F11 | FA11_HUMAN | FXI | Factor XIa | Factor XIa (fXIa) | PTA | Plasma thromboplastin antecedent |
Type: | Enzyme |
Mol. Mass.: | 70130.58 |
Organism: | Homo sapiens (Human) |
Description: | P03951 |
Residue: | 625 |
Sequence: | MIFLYQVVHFILFTSVSGECVTQLLKDTCFEGGDITTVFTPSAKYCQVVCTYHPRCLLFT
FTAESPSEDPTRWFTCVLKDSVTETLPRVNRTAAISGYSFKQCSHQISACNKDIYVDLDM
KGINYNSSVAKSAQECQERCTDDVHCHFFTYATRQFPSLEHRNICLLKHTQTGTPTRITK
LDKVVSGFSLKSCALSNLACIRDIFPNTVFADSNIDSVMAPDAFVCGRICTHHPGCLFFT
FFSQEWPKESQRNLCLLKTSESGLPSTRIKKSKALSGFSLQSCRHSIPVFCHSSFYHDTD
FLGEELDIVAAKSHEACQKLCTNAVRCQFFTYTPAQASCNEGKGKCYLKLSSNGSPTKIL
HGRGGISGYTLRLCKMDNECTTKIKPRIVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSI
IGNQWILTAAHCFYGVESPKILRVYSGILNQSEIKEDTSFFGVQEIIIHDQYKMAESGYD
IALLKLETTVNYTDSQRPICLPSKGDRNVIYTDCWVTGWGYRKLRDKIQNTLQKAKIPLV
TNEECQKRYRGHKITHKMICAGYREGGKDACKGDSGGPLSCKHNEVWHLVGITSWGEGCA
QRERPGVYTNVVEYVDWILEKTQAV
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BDBM617854 |
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n/a |
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Name | BDBM617854 |
Synonyms: | 6-(3-Chloro-6-(difluoromethyl)-2-fluorophenyl)-N-(1-((S or R)-1-(5-methyl-6-((1R,5S)-2-oxo-3-azabicyclo[3.1.0]hexan-3-yl)pyridin-3-yl)ethyl)-1H-pyrazol-4-yl)pyrazine-2-carboxamide | US20230286958, Example 66 | US20230286958, Example 67 |
Type | Small organic molecule |
Emp. Form. | C28H23ClF3N7O2 |
Mol. Mass. | 581.976 |
SMILES | CC(c1cnc(N2C[C@H]3C[C@H]3C2=O)c(C)c1)n1cc(NC(=O)c2cncc(n2)-c2c(F)c(Cl)ccc2C(F)F)cn1 |
Structure |
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