| Reaction Details |
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 | Report a problem with these data |
| Target | Coagulation factor XI |
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| Ligand | BDBM617998 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Factor XIa Assay |
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| IC50 | 2031±n/a nM |
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| Citation |  Jabri, S; Ogawa, AK; Sinz, CJ; Hicks, JD; Cheng, AC; Gao, Y; Yang, S; Bao, J; Hayes, DA; Lang, SB; Taoka, BM; Tian, M; Shearn-Nance, GP; Kuang, R; Lombardo, MJ; Wu, Z; Zhao, Z PLASMA KALLIKREIN INHIBITORS US Patent US20230286958 Publication Date 9/14/2023 |
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| More Info.: | Get all data from this article, Assay Method |
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| Coagulation factor XI |
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| Name: | Coagulation factor XI |
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| Synonyms: | Coagulation factor XIa | Coagulation factor XIa heavy chain | Coagulation factor XIa light chain | F11 | FA11_HUMAN | FXI | Factor XIa | Factor XIa (fXIa) | PTA | Plasma thromboplastin antecedent |
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| Type: | Enzyme |
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| Mol. Mass.: | 70130.58 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P03951 |
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| Residue: | 625 |
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| Sequence: | MIFLYQVVHFILFTSVSGECVTQLLKDTCFEGGDITTVFTPSAKYCQVVCTYHPRCLLFT
FTAESPSEDPTRWFTCVLKDSVTETLPRVNRTAAISGYSFKQCSHQISACNKDIYVDLDM
KGINYNSSVAKSAQECQERCTDDVHCHFFTYATRQFPSLEHRNICLLKHTQTGTPTRITK
LDKVVSGFSLKSCALSNLACIRDIFPNTVFADSNIDSVMAPDAFVCGRICTHHPGCLFFT
FFSQEWPKESQRNLCLLKTSESGLPSTRIKKSKALSGFSLQSCRHSIPVFCHSSFYHDTD
FLGEELDIVAAKSHEACQKLCTNAVRCQFFTYTPAQASCNEGKGKCYLKLSSNGSPTKIL
HGRGGISGYTLRLCKMDNECTTKIKPRIVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSI
IGNQWILTAAHCFYGVESPKILRVYSGILNQSEIKEDTSFFGVQEIIIHDQYKMAESGYD
IALLKLETTVNYTDSQRPICLPSKGDRNVIYTDCWVTGWGYRKLRDKIQNTLQKAKIPLV
TNEECQKRYRGHKITHKMICAGYREGGKDACKGDSGGPLSCKHNEVWHLVGITSWGEGCA
QRERPGVYTNVVEYVDWILEKTQAV
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| BDBM617998 |
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| n/a |
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| Name | BDBM617998 |
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| Synonyms: | 6-(3-Chloro-6-(difluoromethyl)-2-fluorophenyl)-3-((S or R)-1-hydroxyethyl)-N-(1-((S or R)-1-(5-methyl-6-((1R,5S)-2-oxo-3-azabicyclo[3.1.0]hexan-3-yl)pyridin-3-yl)ethyl)-1H-pyrazol-4-yl)pyrazine-2-carboxamide | US20230286958, Example 210 | US20230286958, Example 211 | US20230286958, Example 212 | US20230286958, Example 213 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H27ClF3N7O3 |
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| Mol. Mass. | 626.029 |
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| SMILES | CC(O)c1ncc(nc1C(=O)Nc1cnn(c1)C(C)c1cnc(N2C[C@H]3C[C@H]3C2=O)c(C)c1)-c1c(F)c(Cl)ccc1C(F)F |
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| Structure | 
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