Reaction Details |
![](/images/Email.png) | Report a problem with these data |
Target | Acetylcholinesterase |
---|
Ligand | BDBM9347 |
---|
Substrate/Competitor | BDBM8959 |
---|
Meas. Tech. | Enzyme Inhibition Assay |
---|
pH | 7.4±n/a |
---|
Temperature | 298.15±n/a K |
---|
IC50 | 4000±n/a nM |
---|
Citation | Shutske, GM; Pierrat, FA; Kapples, KJ; Cornfeldt, ML; Szewczak, MR; Huger, FP; Bores, GM; Haroutunian, V; Davis, KL 9-Amino-1,2,3,4-tetrahydroacridin-1-ols: synthesis and evaluation as potential Alzheimer's disease therapeutics. J Med Chem32:1805-13 (1989) [PubMed] Article |
---|
More Info.: | Get all data from this article, Solution Info, Assay Method |
---|
|
Acetylcholinesterase |
---|
Name: | Acetylcholinesterase |
Synonyms: | ACES_RAT | Acetylcholinesterase (AChE) | Acetylcholinesterase and butyrylcholinesterase (AChE and BChE) | Acetylcholinesterase precursor | Acetylcholinesterase, AChE | Ache |
Type: | Enzyme |
Mol. Mass.: | 68193.62 |
Organism: | Rattus norvegicus (rat) |
Description: | P37136 |
Residue: | 614 |
Sequence: | MRPPWYPLHTPSLASPLLFLLLSLLGGGARAEGREDPQLLVRVRGGQLRGIRLKAPGGPV
SAFLGIPFAEPPVGSRRFMPPEPKRPWSGILDATTFQNVCYQYVDTLYPGFEGTEMWNPN
RELSEDCLYLNVWTPYPRPTSPTPVLIWIYGGGFYSGASSLDVYDGRFLAQVEGTVLVSM
NYRVGTFGFLALPGSREAPGNVGLLDQRLALQWVQENIAAFGGDPMSVTLFGESAGAASV
GMHILSLPSRSLFHRAVLQSGTPNGPWATVSAGEARRRATLLARLVGCPPGGAGGNDTEL
ISCLRTRPAQDLVDHEWHVLPQESIFRFSFVPVVDGDFLSDTPDALINTGDFQDLQVLVG
VVKDEGSYFLVYGVPGFSKDNESLISRAQFLAGVRIGVPQASDLAAEAVVLHYTDWLHPE
DPAHLRDAMSAVVGDHNVVCPVAQLAGRLAAQGARVYAYIFEHRASTLTWPLWMGVPHGY
EIEFIFGLPLDPSLNYTVEERIFAQRLMQYWTNFARTGDPNDPRDSKSPRWPPYTTAAQQ
YVSLNLKPLEVRRGLRAQTCAFWNRFLPKLLSATDTLDEAERQWKAEFHRWSSYMVHWKN
QFDHYSKQERCSDL
|
|
|
BDBM9347 |
---|
BDBM8959 |
---|
Name | BDBM9347 |
Synonyms: | (2Z)-but-2-enedioic acid; 9-amino-1,2,3,4-tetrahydroacridin-1-ol | 9-Amino-1 ,2,3,4-tetrahydroacridin-1-ol deriv. 1a | 9-amino-1,2,3,4-tetrahydroacridin-1-ol maleate | CHEMBL23455 | CHEMBL51934 | HP-029 |
Type | Small organic molecule |
Emp. Form. | C13H14N2O |
Mol. Mass. | 214.2631 |
SMILES | Nc1c2C(O)CCCc2nc2ccccc12 |
Structure |
|