| Reaction Details |
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 | Report a problem with these data |
| Target | Poly [ADP-ribose] polymerase 2 |
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| Ligand | BDBM630979 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Biochemical (FP) Assay |
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| IC50 | 11000±n/a nM |
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| Citation |  Hoffman, RL; Dong, Q; Kaldor, SW; Trzoss, L; Va, PJ Azetidine and pyrrolidine PARP1 inhibitors and uses thereof US Patent US11802128 Publication Date 10/31/2023 |
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| More Info.: | Get all data from this article, Assay Method |
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| Poly [ADP-ribose] polymerase 2 |
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| Name: | Poly [ADP-ribose] polymerase 2 |
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| Synonyms: | (ARTD2 or PARP2) | ADPRT2 | ADPRTL2 | PARP2 | PARP2_HUMAN | Poly [ADP-ribose] polymerase 2 (PARP-2) | Poly [ADP-ribose] polymerase 2 (PARP2) |
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| Type: | Enzyme |
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| Mol. Mass.: | 66225.70 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9UGN5 |
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| Residue: | 583 |
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| Sequence: | MAARRRRSTGGGRARALNESKRVNNGNTAPEDSSPAKKTRRCQRQESKKMPVAGGKANKD
RTEDKQDGMPGRSWASKRVSESVKALLLKGKAPVDPECTAKVGKAHVYCEGNDVYDVMLN
QTNLQFNNNKYYLIQLLEDDAQRNFSVWMRWGRVGKMGQHSLVACSGNLNKAKEIFQKKF
LDKTKNNWEDREKFEKVPGKYDMLQMDYATNTQDEEETKKEESLKSPLKPESQLDLRVQE
LIKLICNVQAMEEMMMEMKYNTKKAPLGKLTVAQIKAGYQSLKKIEDCIRAGQHGRALME
ACNEFYTRIPHDFGLRTPPLIRTQKELSEKIQLLEALGDIEIAIKLVKTELQSPEHPLDQ
HYRNLHCALRPLDHESYEFKVISQYLQSTHAPTHSDYTMTLLDLFEVEKDGEKEAFREDL
HNRMLLWHGSRMSNWVGILSHGLRIAPPEAPITGYMFGKGIYFADMSSKSANYCFASRLK
NTGLLLLSEVALGQCNELLEANPKAEGLLQGKHSTKGLGKMAPSSAHFVTLNGSTVPLGP
ASDTGILNPDGYTLNYNEYIVYNPNQVRMRYLLKVQFNFLQLW
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| BDBM630979 |
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| n/a |
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| Name | BDBM630979 |
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| Synonyms: | US11802128, Example 44 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H27N5O4 |
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| Mol. Mass. | 449.5023 |
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| SMILES | CCc1cc2ncc(CN3C[C@H](Oc4ccc(nc4)C(=O)NC4COC4)[C@H]3C)cc2[nH]c1=O |r| |
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| Structure | 
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